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Virus Zika nelle donne gavide di Rio de Janeiro: rapporto preliminare

tetano

Editor, Senior Moderator
NEJM: Zika Virus Infection in Pregnant Women in Rio de Janeiro ? Preliminary Report
http://www.nejm.org/doi/full/10.1056/NEJMoa1602412
88 donne sono state arruolate da settembre 2015 a Febbraio 2016, di queste 72 sono risultate positive per il virus nel sangue, urine o entrambi.
I sintomi predominante sono stati rash maculare o maculo-papulare pruriginoso discendente, artralgie, congiuntivite e cefalea. Il 28% ha manifestato febbre di basso grado.
L' ecografia fetale ? stata eseguita in 42 donne (58%) positive per il virus e anormalit? fetali sono state riscontrate in 12 (29%) rispetto a nessuna di 16 donne negative.
Eventi avversi sono stati 2 aborti a 36 e 38 settimane, ridotta crescita intrauterina con o senza microcefalia in 5 casi, calcificazioni ventricolari in 7 casi e anomalie del fluido amniotico o cerebrale o del flusso dell' arteria ombelicale.
Ad oggi 8 donne su 42 hanno partorito e in queste i dati ecografici sono stati confermati.
Conclusioni: nonostante i sintomi lievi, l' infezione risulta associati a gravi sequele, come aborto, insufficienza placentare, ridotta crescita fetale e danno del sistema nervoso.
 
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