tetano
Editor, Senior Moderator
Virus Res
. 2020 Sep 25;198176.
doi: 10.1016/j.virusres.2020.198176. Online ahead of print.
Transcription-based drug repurposing for COVID-19
Richard Killick[SUP] 1 [/SUP], Clive Ballard[SUP] 2 [/SUP], Patrick Doherty[SUP] 3 [/SUP], Gareth Williams[SUP] 4 [/SUP]
Affiliations
Abstract
We have utilised the transcriptional response of lung epithelial cells following infection by the original Severe Acute Respiratory Syndrome coronavirus (SARS) to identify repositionable drugs for COVID-19. Drugs best able to recapitulate the infection profile are highly enriched for antiviral activity. Nine of these have been tested against SARS-2 and found to potently antagonise SARS-2 infection/replication, with a number now being considered for clinical trials. It is hoped that this approach may serve to broaden the spectrum of approved drugs that should be further assessed as potential anti-COVID-19 agents and may help elucidate how this seemingly disparate collection of drugs are able to inhibit SARS-2 infection/replication.
Keywords: COVID-19; Gene expression; Repurposing.
. 2020 Sep 25;198176.
doi: 10.1016/j.virusres.2020.198176. Online ahead of print.
Transcription-based drug repurposing for COVID-19
Richard Killick[SUP] 1 [/SUP], Clive Ballard[SUP] 2 [/SUP], Patrick Doherty[SUP] 3 [/SUP], Gareth Williams[SUP] 4 [/SUP]
Affiliations
- PMID: 32987033
- PMCID: PMC7518800
- DOI: 10.1016/j.virusres.2020.198176
Abstract
We have utilised the transcriptional response of lung epithelial cells following infection by the original Severe Acute Respiratory Syndrome coronavirus (SARS) to identify repositionable drugs for COVID-19. Drugs best able to recapitulate the infection profile are highly enriched for antiviral activity. Nine of these have been tested against SARS-2 and found to potently antagonise SARS-2 infection/replication, with a number now being considered for clinical trials. It is hoped that this approach may serve to broaden the spectrum of approved drugs that should be further assessed as potential anti-COVID-19 agents and may help elucidate how this seemingly disparate collection of drugs are able to inhibit SARS-2 infection/replication.
Keywords: COVID-19; Gene expression; Repurposing.