tetano
Editor, Senior Moderator
Virus Res
. 2020 Jun 2;198043.
doi: 10.1016/j.virusres.2020.198043. Online ahead of print.
Clinical Features of Familial Clustering in Patients Infected With 2019 Novel Coronavirus in Wuhan, China
Jinzhong Li[SUP] 1 [/SUP], Xiaobing Gong[SUP] 1 [/SUP], Zhigang Wang[SUP] 2 [/SUP], Renzhou Chen[SUP] 3 [/SUP], Taoyuan Li[SUP] 1 [/SUP], Dongyu Zeng[SUP] 1 [/SUP], Minran Li[SUP] 4 [/SUP]
Affiliations
Abstract
An epidemic caused by SARS-Coronavirus-2 (SARS-CoV-2) infection has appeared in Wuhan City in December 2019 and subsequently spread in China. The disease has shown a "clustering epidemic" pattern, and family-clustered onset has been the main characteristic. We collected data from 130 cases from 35 cluster-onset families (COFs) and 41 cases from 16 solitary-onset families (SOFs). The incidence 2019 coronavirus disease (COVID-19) in COFs was significantly higher than that of SOFs. Our study also showed that patients with exposure to high-risk factors (respiratory droplets and close contact), advanced age, and comorbidities were more likely to develop COVID-19 in the COFs. In addition, advanced age and elevated neutrophil/lymphocyte ratio (NLR) were risk factors for death in patients with SARS-CoV-2 infection in the COFs.
Keywords: 2019 coronavirus disease; SARS-Coronavirus-2; cluster-onset families; solitary-onset families.
. 2020 Jun 2;198043.
doi: 10.1016/j.virusres.2020.198043. Online ahead of print.
Clinical Features of Familial Clustering in Patients Infected With 2019 Novel Coronavirus in Wuhan, China
Jinzhong Li[SUP] 1 [/SUP], Xiaobing Gong[SUP] 1 [/SUP], Zhigang Wang[SUP] 2 [/SUP], Renzhou Chen[SUP] 3 [/SUP], Taoyuan Li[SUP] 1 [/SUP], Dongyu Zeng[SUP] 1 [/SUP], Minran Li[SUP] 4 [/SUP]
Affiliations
- PMID: 32502551
- PMCID: PMC7265838
- DOI: 10.1016/j.virusres.2020.198043
Abstract
An epidemic caused by SARS-Coronavirus-2 (SARS-CoV-2) infection has appeared in Wuhan City in December 2019 and subsequently spread in China. The disease has shown a "clustering epidemic" pattern, and family-clustered onset has been the main characteristic. We collected data from 130 cases from 35 cluster-onset families (COFs) and 41 cases from 16 solitary-onset families (SOFs). The incidence 2019 coronavirus disease (COVID-19) in COFs was significantly higher than that of SOFs. Our study also showed that patients with exposure to high-risk factors (respiratory droplets and close contact), advanced age, and comorbidities were more likely to develop COVID-19 in the COFs. In addition, advanced age and elevated neutrophil/lymphocyte ratio (NLR) were risk factors for death in patients with SARS-CoV-2 infection in the COFs.
Keywords: 2019 coronavirus disease; SARS-Coronavirus-2; cluster-onset families; solitary-onset families.