tetano
Editor, Senior Moderator
Vet Res. 2019 Oct 7;50(1):77. doi: 10.1186/s13567-019-0699-y. [h=1]Virus persistence in pig herds led to successive reassortment events between swine and human influenza A viruses, resulting in the emergence of a novel triple-reassortant swine influenza virus.[/h]
Chastagner A[SUP]1,[/SUP][SUP]2[/SUP], Bonin E[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Fablet C[SUP]4,[/SUP][SUP]2[/SUP], Qu?guiner S[SUP]1,[/SUP][SUP]2[/SUP], Hirchaud E[SUP]5,[/SUP][SUP]2[/SUP], Lucas P[SUP]5,[/SUP][SUP]2[/SUP], Gorin S[SUP]1,[/SUP][SUP]2[/SUP], Barbier N[SUP]1,[/SUP][SUP]2[/SUP], B?ven V[SUP]5,[/SUP][SUP]2[/SUP], Garin E[SUP]6,[/SUP][SUP]7,[/SUP][SUP]8[/SUP], Blanchard Y[SUP]5,[/SUP][SUP]2[/SUP], Rose N[SUP]4,[/SUP][SUP]2[/SUP], Herv? S[SUP]1,[/SUP][SUP]2[/SUP], Simon G[SUP]9,[/SUP][SUP]10[/SUP].
[h=3]Author information[/h] 1 Swine Virology Immunology Unit, Ploufragan-Plouzan?-Niort Laboratory, ANSES, BP53, 22440, Ploufragan, France. 2 Bretagne Loire University, Cit? internationale, 1 place Paul Ricoeur, CS 54417, 35044, Rennes, France. 3 INRA, US 1426, GeT-PlaGe, 24 chemin de borde rouge - Auzeville, CS 52627, 31326, Castanet-Tolosan, France. 4 Epidemiology, Health and Welfare Unit, Ploufragan-Plouzan?-Niort Laboratory, ANSES, BP53, 22440, Ploufragan, France. 5 Viral Genetic and Biosecurity Unit, Ploufragan-Plouzan?-Niort Laboratory, ANSES, BP53, 22440, Ploufragan, France. 6 Animal Health Service, Coop de France, 43 Rue Sedaine, 75538, Paris cedex 11, France. 7 Operational Team, ESA Platform, 31 Avenue Garnier, 69007, Lyon, France. 8 GDS-France, 37 Rue de Lyon, 75012, Paris, France. 9 Swine Virology Immunology Unit, Ploufragan-Plouzan?-Niort Laboratory, ANSES, BP53, 22440, Ploufragan, France. gaelle.simon@anses.fr. 10 Bretagne Loire University, Cit? internationale, 1 place Paul Ricoeur, CS 54417, 35044, Rennes, France. gaelle.simon@anses.fr.
[h=3]Abstract[/h] This report describes the detection of a triple reassortant swine influenza A virus of H1[SUB]av[/SUB]N2 subtype. It evolved from an avian-like swine H1[SUB]av[/SUB]N1 that first acquired the N2 segment from a seasonal H3N2, then the M segment from a 2009 pandemic H1N1, in two reassortments estimated to have occurred 10 years apart. This study illustrates how recurrent influenza infections increase the co-infection risk and facilitate evolutionary jumps by successive gene exchanges. It recalls the importance of appropriate biosecurity measures inside holdings to limit virus persistence and interspecies transmissions, which both contribute to the emergence of new potentially zoonotic viruses.
PMID: 31590684 DOI: 10.1186/s13567-019-0699-y
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Chastagner A[SUP]1,[/SUP][SUP]2[/SUP], Bonin E[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Fablet C[SUP]4,[/SUP][SUP]2[/SUP], Qu?guiner S[SUP]1,[/SUP][SUP]2[/SUP], Hirchaud E[SUP]5,[/SUP][SUP]2[/SUP], Lucas P[SUP]5,[/SUP][SUP]2[/SUP], Gorin S[SUP]1,[/SUP][SUP]2[/SUP], Barbier N[SUP]1,[/SUP][SUP]2[/SUP], B?ven V[SUP]5,[/SUP][SUP]2[/SUP], Garin E[SUP]6,[/SUP][SUP]7,[/SUP][SUP]8[/SUP], Blanchard Y[SUP]5,[/SUP][SUP]2[/SUP], Rose N[SUP]4,[/SUP][SUP]2[/SUP], Herv? S[SUP]1,[/SUP][SUP]2[/SUP], Simon G[SUP]9,[/SUP][SUP]10[/SUP].
[h=3]Author information[/h] 1 Swine Virology Immunology Unit, Ploufragan-Plouzan?-Niort Laboratory, ANSES, BP53, 22440, Ploufragan, France. 2 Bretagne Loire University, Cit? internationale, 1 place Paul Ricoeur, CS 54417, 35044, Rennes, France. 3 INRA, US 1426, GeT-PlaGe, 24 chemin de borde rouge - Auzeville, CS 52627, 31326, Castanet-Tolosan, France. 4 Epidemiology, Health and Welfare Unit, Ploufragan-Plouzan?-Niort Laboratory, ANSES, BP53, 22440, Ploufragan, France. 5 Viral Genetic and Biosecurity Unit, Ploufragan-Plouzan?-Niort Laboratory, ANSES, BP53, 22440, Ploufragan, France. 6 Animal Health Service, Coop de France, 43 Rue Sedaine, 75538, Paris cedex 11, France. 7 Operational Team, ESA Platform, 31 Avenue Garnier, 69007, Lyon, France. 8 GDS-France, 37 Rue de Lyon, 75012, Paris, France. 9 Swine Virology Immunology Unit, Ploufragan-Plouzan?-Niort Laboratory, ANSES, BP53, 22440, Ploufragan, France. gaelle.simon@anses.fr. 10 Bretagne Loire University, Cit? internationale, 1 place Paul Ricoeur, CS 54417, 35044, Rennes, France. gaelle.simon@anses.fr.
[h=3]Abstract[/h] This report describes the detection of a triple reassortant swine influenza A virus of H1[SUB]av[/SUB]N2 subtype. It evolved from an avian-like swine H1[SUB]av[/SUB]N1 that first acquired the N2 segment from a seasonal H3N2, then the M segment from a 2009 pandemic H1N1, in two reassortments estimated to have occurred 10 years apart. This study illustrates how recurrent influenza infections increase the co-infection risk and facilitate evolutionary jumps by successive gene exchanges. It recalls the importance of appropriate biosecurity measures inside holdings to limit virus persistence and interspecies transmissions, which both contribute to the emergence of new potentially zoonotic viruses.
PMID: 31590684 DOI: 10.1186/s13567-019-0699-y
Free full text