tetano
Editor, Senior Moderator
Expert Rev Vaccines. 2013 Feb;12(2):211-24. doi: 10.1586/erv.12.147.
Virus-like particles produced in plants as potential vaccines.
Scotti N, Rybicki EP.
Source
CNR-IGV, National Research Council of Italy, Institute of Plant Genetics, Via Universit? 133, 80055 Portici, Napoli, Italy.
Abstract
Virus-like particles (VLPs) have been produced as candidate vaccines in plants virtually since the introduction of biofarming. Even today, VLPs remain the best candidates for safe, immunogenic, efficacious and inexpensive vaccines. Well-characterized human animal viruses such as HBV, HCV, HIV and HPV, rotaviruses, norovirus, foot and mouth disease viruses and even influenza virus proteins have all been successfully investigated for VLP formation. Proteins have been produced in transgenic plants and via transient expression techniques; simple structures, structures depending on more than one protein, naked and enveloped particles have all been made. There have been multiple proofs of concept, more than a few proofs of efficacy, and several products moved into human trials. This review will cover the history of VLP production in plants, and will explore a few examples in detail to illustrate the potential of such a mode of production for human and animal medicine.
PMID:
23414411
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/23414411
Virus-like particles produced in plants as potential vaccines.
Scotti N, Rybicki EP.
Source
CNR-IGV, National Research Council of Italy, Institute of Plant Genetics, Via Universit? 133, 80055 Portici, Napoli, Italy.
Abstract
Virus-like particles (VLPs) have been produced as candidate vaccines in plants virtually since the introduction of biofarming. Even today, VLPs remain the best candidates for safe, immunogenic, efficacious and inexpensive vaccines. Well-characterized human animal viruses such as HBV, HCV, HIV and HPV, rotaviruses, norovirus, foot and mouth disease viruses and even influenza virus proteins have all been successfully investigated for VLP formation. Proteins have been produced in transgenic plants and via transient expression techniques; simple structures, structures depending on more than one protein, naked and enveloped particles have all been made. There have been multiple proofs of concept, more than a few proofs of efficacy, and several products moved into human trials. This review will cover the history of VLP production in plants, and will explore a few examples in detail to illustrate the potential of such a mode of production for human and animal medicine.
PMID:
23414411
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/23414411