tetano
Editor, Senior Moderator
Virus Genes
. 2022 Aug 16.
doi: 10.1007/s11262-022-01928-2. Online ahead of print.
A dominant internal gene cassette of high pathogenicity avian influenza H7N9 virus raised since 2018
Dongchang He[SUP] 1 2 3 [/SUP], Min Gu[SUP] 1 2 3 [/SUP], Xiaoli Hao[SUP] 1 2 3 [/SUP], Tiansong Zhan[SUP] 1 2 3 [/SUP], Xiyue Wang[SUP] 1 2 3 [/SUP], Xiaoquan Wang[SUP] 1 2 3 [/SUP], Shunlin Hu[SUP] 1 2 3 [/SUP], Xiufan Liu[SUP] 4 5 6 [/SUP]
Affiliations
Abstract
The zoonotic H7N9 avian influenza virus emerged with the H9N2-origin internal gene cassette. Previous studies have reported that genetic reassortments with H9N2 were common in the first five human H7N9 epidemic waves. However, our latest work found that the circulating high pathogenicity H7N9 virus has established a dominant internal gene cassette and has decreased the frequency of reassortment with H9N2 since 2018. This dominant cassette of H7N9 was distinct from the cocirculating H9N2, although they shared a common ancestor. As a result, we suppose that this dominant cassette may benefit the viral population fitness and promote its continuous circulation in chickens.
Keywords: Avian influenza; H7N9; H9N2; High pathogenicity; Internal gene cassette; Viral evolution.
. 2022 Aug 16.
doi: 10.1007/s11262-022-01928-2. Online ahead of print.
A dominant internal gene cassette of high pathogenicity avian influenza H7N9 virus raised since 2018
Dongchang He[SUP] 1 2 3 [/SUP], Min Gu[SUP] 1 2 3 [/SUP], Xiaoli Hao[SUP] 1 2 3 [/SUP], Tiansong Zhan[SUP] 1 2 3 [/SUP], Xiyue Wang[SUP] 1 2 3 [/SUP], Xiaoquan Wang[SUP] 1 2 3 [/SUP], Shunlin Hu[SUP] 1 2 3 [/SUP], Xiufan Liu[SUP] 4 5 6 [/SUP]
Affiliations
- PMID: 35974285
- DOI: 10.1007/s11262-022-01928-2
Abstract
The zoonotic H7N9 avian influenza virus emerged with the H9N2-origin internal gene cassette. Previous studies have reported that genetic reassortments with H9N2 were common in the first five human H7N9 epidemic waves. However, our latest work found that the circulating high pathogenicity H7N9 virus has established a dominant internal gene cassette and has decreased the frequency of reassortment with H9N2 since 2018. This dominant cassette of H7N9 was distinct from the cocirculating H9N2, although they shared a common ancestor. As a result, we suppose that this dominant cassette may benefit the viral population fitness and promote its continuous circulation in chickens.
Keywords: Avian influenza; H7N9; H9N2; High pathogenicity; Internal gene cassette; Viral evolution.
