tetano
Editor, Senior Moderator
Virus Evol
. 2022 Jun 21;8(1):veac049.
doi: 10.1093/ve/veac049. eCollection 2022.
Identification of coronaviruses in farmed wild animals reveals their evolutionary origins in Guangdong, southern China
Xiaohu Wang[SUP] 1 [/SUP], Zhaowen Ren[SUP] 1 [/SUP], Lu Wang[SUP] 1 [/SUP], Jing Chen[SUP] 1 [/SUP], Pian Zhang[SUP] 1 [/SUP], Jin-Ping Chen[SUP] 2 [/SUP], Xiaofan Chen[SUP] 1 [/SUP], Linmiao Li[SUP] 2 [/SUP], Xuhui Lin[SUP] 1 [/SUP], Nanshan Qi[SUP] 1 [/SUP], Shengjun Luo[SUP] 1 [/SUP], Rong Xiang[SUP] 1 [/SUP], Ziguo Yuan[SUP] 3 [/SUP], Jianfeng Zhang[SUP] 1 [/SUP], Gang Wang[SUP] 1 [/SUP], Min-Hua Sun[SUP] 1 [/SUP], Yuan Huang[SUP] 1 [/SUP], Yan Hua[SUP] 4 [/SUP], Jiejian Zou[SUP] 4 [/SUP], Fanghui Hou[SUP] 4 [/SUP], Zhong Huang[SUP] 1 [/SUP], Shouwen Du[SUP] 5 [/SUP], Hua Xiang[SUP] 1 [/SUP], Mingfei Sun[SUP] 1 [/SUP], Quan Liu[SUP] 1 [/SUP], Ming Liao[SUP] 1 [/SUP]
Affiliations
Abstract
Coronavirus infections cause diseases that range from mild to severe in mammals and birds. In this study, we detected coronavirus infections in 748 farmed wild animals of 23 species in Guangdong, southern China, by RT-PCR and metagenomic analysis. We identified four coronaviruses in these wild animals and analysed their evolutionary origins. Coronaviruses detected in Rhizomys sinensis were genetically grouped into canine and rodent coronaviruses, which were likely recombinants of canine and rodent coronaviruses. The coronavirus found in Phasianus colchicus was a recombinant pheasant coronavirus of turkey coronavirus and infectious bronchitis virus. The coronavirus in Paguma larvata had a high nucleotide identity (94.6-98.5 per cent) with a coronavirus of bottlenose dolphin (Tursiops truncates). These findings suggested that the wildlife coronaviruses may have experienced homologous recombination and/or crossed the species barrier, likely resulting in the emergence of new coronaviruses. It is necessary to reduce human-animal interactions by prohibiting the eating and raising of wild animals, which may contribute to preventing the emergence of the next coronavirus pandemic.
Keywords: Paguma larvata; Phasianus colchicus; Rhizomys sinensis; coronavirus; southern China; wild animals.
. 2022 Jun 21;8(1):veac049.
doi: 10.1093/ve/veac049. eCollection 2022.
Identification of coronaviruses in farmed wild animals reveals their evolutionary origins in Guangdong, southern China
Xiaohu Wang[SUP] 1 [/SUP], Zhaowen Ren[SUP] 1 [/SUP], Lu Wang[SUP] 1 [/SUP], Jing Chen[SUP] 1 [/SUP], Pian Zhang[SUP] 1 [/SUP], Jin-Ping Chen[SUP] 2 [/SUP], Xiaofan Chen[SUP] 1 [/SUP], Linmiao Li[SUP] 2 [/SUP], Xuhui Lin[SUP] 1 [/SUP], Nanshan Qi[SUP] 1 [/SUP], Shengjun Luo[SUP] 1 [/SUP], Rong Xiang[SUP] 1 [/SUP], Ziguo Yuan[SUP] 3 [/SUP], Jianfeng Zhang[SUP] 1 [/SUP], Gang Wang[SUP] 1 [/SUP], Min-Hua Sun[SUP] 1 [/SUP], Yuan Huang[SUP] 1 [/SUP], Yan Hua[SUP] 4 [/SUP], Jiejian Zou[SUP] 4 [/SUP], Fanghui Hou[SUP] 4 [/SUP], Zhong Huang[SUP] 1 [/SUP], Shouwen Du[SUP] 5 [/SUP], Hua Xiang[SUP] 1 [/SUP], Mingfei Sun[SUP] 1 [/SUP], Quan Liu[SUP] 1 [/SUP], Ming Liao[SUP] 1 [/SUP]
Affiliations
- PMID: 35795295
- PMCID: PMC9252129
- DOI: 10.1093/ve/veac049
Abstract
Coronavirus infections cause diseases that range from mild to severe in mammals and birds. In this study, we detected coronavirus infections in 748 farmed wild animals of 23 species in Guangdong, southern China, by RT-PCR and metagenomic analysis. We identified four coronaviruses in these wild animals and analysed their evolutionary origins. Coronaviruses detected in Rhizomys sinensis were genetically grouped into canine and rodent coronaviruses, which were likely recombinants of canine and rodent coronaviruses. The coronavirus found in Phasianus colchicus was a recombinant pheasant coronavirus of turkey coronavirus and infectious bronchitis virus. The coronavirus in Paguma larvata had a high nucleotide identity (94.6-98.5 per cent) with a coronavirus of bottlenose dolphin (Tursiops truncates). These findings suggested that the wildlife coronaviruses may have experienced homologous recombination and/or crossed the species barrier, likely resulting in the emergence of new coronaviruses. It is necessary to reduce human-animal interactions by prohibiting the eating and raising of wild animals, which may contribute to preventing the emergence of the next coronavirus pandemic.
Keywords: Paguma larvata; Phasianus colchicus; Rhizomys sinensis; coronavirus; southern China; wild animals.