Giuseppe
Emeritus
Virology. 2009 Jun 1. [Epub ahead of print]
Pulse-oximetry accurately predicts lung pathology and the immune response during influenza infection.
Verhoeven D, Teijaro JR, Farber DL. Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21210, USA.
In animal models of influenza, systemic weight loss is the primary indicator of morbidity from infection, which does not assess local lung pathology or the immune response. Here, we used a mouse-adapted pulse-oximeter as a non-invasive clinical readout of lung function during influenza infection in mice, and found direct correlations between oxygen saturation levels and lung pathology, that reflected the morbidity and survival from influenza infection.
We found blood oxygen levels to be a more accurate assessment than weight-loss morbidity in predicting lung pathology in hosts infected with different viral doses, and in assessing immune-mediated viral clearance in the lung.
PMID: 19493556 [PubMed - as supplied by publisher]
-
------
Pulse-oximetry accurately predicts lung pathology and the immune response during influenza infection.
Verhoeven D, Teijaro JR, Farber DL. Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21210, USA.
In animal models of influenza, systemic weight loss is the primary indicator of morbidity from infection, which does not assess local lung pathology or the immune response. Here, we used a mouse-adapted pulse-oximeter as a non-invasive clinical readout of lung function during influenza infection in mice, and found direct correlations between oxygen saturation levels and lung pathology, that reflected the morbidity and survival from influenza infection.
We found blood oxygen levels to be a more accurate assessment than weight-loss morbidity in predicting lung pathology in hosts infected with different viral doses, and in assessing immune-mediated viral clearance in the lung.
PMID: 19493556 [PubMed - as supplied by publisher]
-
------