tetano
Editor, Senior Moderator
Virology
. 2025 Jan 27:604:110426.
doi: 10.1016/j.virol.2025.110426. Online ahead of print. Bats as a mixing vessel for generation of novel coronaviruses: Co-circulation and co-infection of coronaviruses and other viruses
AntonioC P Wong[SUP] 1 [/SUP], SusannaK P Lau[SUP] 2 [/SUP], PatrickC Y Woo[SUP] 3 [/SUP]
Affiliations
Bats are the hosts of a wide variety of coronaviruses (CoVs) of the genera Alphacoronavirus and Betacoronavirus. The presence of more than one CoV species or strain in a single bat species greatly enhances the chance of genetic exchange among the CoVs, mainly through homologous recombination, and hence enhance the generation of novel CoV species or strains that may adapt to human or other animals and result in future epidemics. In this article, we review the evidence for co-circulation and/or co-infection of two or more CoVs in the same bat species, including co-infection with different strains of a CoV, co-circulation/co-infection of different alphaCoVs or betaCoVs, and co-circulation/co-infection of alphaCoVs and betaCoVs together. With next-generation sequencing, there has been a recent explosion of such discoveries. It is anticipated that countless more similar findings will be made in the near future.
Keywords: Bat; Co-circulation; Co-infection; Coronavirus; Infection; Virus.
. 2025 Jan 27:604:110426.
doi: 10.1016/j.virol.2025.110426. Online ahead of print. Bats as a mixing vessel for generation of novel coronaviruses: Co-circulation and co-infection of coronaviruses and other viruses
AntonioC P Wong[SUP] 1 [/SUP], SusannaK P Lau[SUP] 2 [/SUP], PatrickC Y Woo[SUP] 3 [/SUP]
Affiliations
- PMID: 39922026
- DOI: 10.1016/j.virol.2025.110426
Bats are the hosts of a wide variety of coronaviruses (CoVs) of the genera Alphacoronavirus and Betacoronavirus. The presence of more than one CoV species or strain in a single bat species greatly enhances the chance of genetic exchange among the CoVs, mainly through homologous recombination, and hence enhance the generation of novel CoV species or strains that may adapt to human or other animals and result in future epidemics. In this article, we review the evidence for co-circulation and/or co-infection of two or more CoVs in the same bat species, including co-infection with different strains of a CoV, co-circulation/co-infection of different alphaCoVs or betaCoVs, and co-circulation/co-infection of alphaCoVs and betaCoVs together. With next-generation sequencing, there has been a recent explosion of such discoveries. It is anticipated that countless more similar findings will be made in the near future.
Keywords: Bat; Co-circulation; Co-infection; Coronavirus; Infection; Virus.