tetano
Editor, Senior Moderator
Virol Sin
. 2023 Jul 4;S1995-820X(23)00080-9.
doi: 10.1016/j.virs.2023.06.011. Online ahead of print. SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection
Ziwei Li[SUP] 1 [/SUP], Tiandan Xiang[SUP] 1 [/SUP], Boyun Liang[SUP] 1 [/SUP], Jing Liu[SUP] 1 [/SUP], Hui Deng[SUP] 1 [/SUP], Xuecheng Yang[SUP] 1 [/SUP], Hua Wang[SUP] 2 [/SUP], Xuemei Feng[SUP] 1 [/SUP], Gennadiy Zelinskyy[SUP] 3 [/SUP], Mirko Trilling[SUP] 3 [/SUP], Kathrin Sutter[SUP] 3 [/SUP], Mengji Lu[SUP] 3 [/SUP], Ulf Dittmer[SUP] 3 [/SUP], Baoju Wang[SUP] 1 [/SUP], Dongliang Yang[SUP] 4 [/SUP], Xin Zheng[SUP] 5 [/SUP], Jia Liu[SUP] 6 [/SUP]
Affiliations
A key question in the coronavirus disease 2019 (COVID-19) pandemic is the duration of specific T cell responses against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) post primiry infection, which is difficult to address due to the large-scale of COVID-19 vaccination and re-exposure to the virus. Here, we conducted an analysis of the long-term SARS-CoV-2-specific T cell responses in an uniqe cohort of convalescent individuals (CIs) that were among the first to be infected worldwide and without any possible antigen re-exposure since then. Magnitude and breadth of SARS-CoV-2-specific T cell responses correlated inversely with the time that had elapsed from disease onset and the age of those CIs. The mean magnitude of SARS-CoV-2-specific CD4 and CD8 T cell responses decreased about 82% and 76%, respectively, over the time period of ten months after infection. Accordingly, the longitudinal analysis also demonstrated that SARS-CoV-2-specific T cell responses waned significantly in 75% of CIs during the follow-up. Collectively, we provide a comprehensive characterization of the long-term memory T cell response in CIs, suggesting that robust SARS-CoV-2-specific T cell immunity post primary infection may be less durable than previously expected.
Keywords: COVID-19; SARS-CoV-2; T cell response; convalescence.
. 2023 Jul 4;S1995-820X(23)00080-9.
doi: 10.1016/j.virs.2023.06.011. Online ahead of print. SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection
Ziwei Li[SUP] 1 [/SUP], Tiandan Xiang[SUP] 1 [/SUP], Boyun Liang[SUP] 1 [/SUP], Jing Liu[SUP] 1 [/SUP], Hui Deng[SUP] 1 [/SUP], Xuecheng Yang[SUP] 1 [/SUP], Hua Wang[SUP] 2 [/SUP], Xuemei Feng[SUP] 1 [/SUP], Gennadiy Zelinskyy[SUP] 3 [/SUP], Mirko Trilling[SUP] 3 [/SUP], Kathrin Sutter[SUP] 3 [/SUP], Mengji Lu[SUP] 3 [/SUP], Ulf Dittmer[SUP] 3 [/SUP], Baoju Wang[SUP] 1 [/SUP], Dongliang Yang[SUP] 4 [/SUP], Xin Zheng[SUP] 5 [/SUP], Jia Liu[SUP] 6 [/SUP]
Affiliations
- PMID: 37414153
- DOI: 10.1016/j.virs.2023.06.011
A key question in the coronavirus disease 2019 (COVID-19) pandemic is the duration of specific T cell responses against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) post primiry infection, which is difficult to address due to the large-scale of COVID-19 vaccination and re-exposure to the virus. Here, we conducted an analysis of the long-term SARS-CoV-2-specific T cell responses in an uniqe cohort of convalescent individuals (CIs) that were among the first to be infected worldwide and without any possible antigen re-exposure since then. Magnitude and breadth of SARS-CoV-2-specific T cell responses correlated inversely with the time that had elapsed from disease onset and the age of those CIs. The mean magnitude of SARS-CoV-2-specific CD4 and CD8 T cell responses decreased about 82% and 76%, respectively, over the time period of ten months after infection. Accordingly, the longitudinal analysis also demonstrated that SARS-CoV-2-specific T cell responses waned significantly in 75% of CIs during the follow-up. Collectively, we provide a comprehensive characterization of the long-term memory T cell response in CIs, suggesting that robust SARS-CoV-2-specific T cell immunity post primary infection may be less durable than previously expected.
Keywords: COVID-19; SARS-CoV-2; T cell response; convalescence.