tetano
Editor, Senior Moderator
Virol J
. 2024 Aug 12;21(1):185.
doi: 10.1186/s12985-024-02462-3. Unveiling the intersection: ferroptosis in influenza virus infection
Arash Letafati[SUP] 1 [/SUP], Zahra Taghiabadi[SUP] 2 [/SUP], Omid Salahi Ardekani[SUP] 3 [/SUP], Simin Abbasi[SUP] 1 [/SUP], Ali Qaraee Najafabadi[SUP] 4 [/SUP], Negar Nayerain Jazi[SUP] 3 [/SUP], Roben Soheili[SUP] 5 [/SUP], Ramón Rodrigo[SUP] 6 [/SUP], Jila Yavarian[SUP] 7 [/SUP], Luciano Saso[SUP] 8 [/SUP]
Affiliations
The influenza virus (IFV) imposes a considerable health and economic burden globally, requiring a comprehensive understanding of its pathogenic mechanisms. Ferroptosis, an iron-dependent lipid peroxidation cell death pathway, holds unique implications for the antioxidant defense system, with possible contributions to inflammation. This exploration focuses on the dynamic interplay between ferroptosis and the host defense against viruses, emphasizing the influence of IFV infections on the activation of the ferroptosis pathway. IFV causes different types of cell death, including apoptosis, necrosis, and ferroptosis. IFV-induced ferroptotic cell death is mediated by alterations in iron homeostasis, intensifying the accumulation of reactive oxygen species and promoting lipid peroxidation. A comprehensive investigation into the mechanism of ferroptosis in viral infections, specifically IFV, has great potential to identify therapeutic strategies. This understanding may pave the way for the development of drugs using ferroptosis inhibitors, presenting an effective approach to suppress viral infections.
Keywords: Cell death; Ferroptosis; Inflammation; Influenza virus; Lipid peroxidation; Oxidative stress.
. 2024 Aug 12;21(1):185.
doi: 10.1186/s12985-024-02462-3. Unveiling the intersection: ferroptosis in influenza virus infection
Arash Letafati[SUP] 1 [/SUP], Zahra Taghiabadi[SUP] 2 [/SUP], Omid Salahi Ardekani[SUP] 3 [/SUP], Simin Abbasi[SUP] 1 [/SUP], Ali Qaraee Najafabadi[SUP] 4 [/SUP], Negar Nayerain Jazi[SUP] 3 [/SUP], Roben Soheili[SUP] 5 [/SUP], Ramón Rodrigo[SUP] 6 [/SUP], Jila Yavarian[SUP] 7 [/SUP], Luciano Saso[SUP] 8 [/SUP]
Affiliations
- PMID: 39135112
- DOI: 10.1186/s12985-024-02462-3
The influenza virus (IFV) imposes a considerable health and economic burden globally, requiring a comprehensive understanding of its pathogenic mechanisms. Ferroptosis, an iron-dependent lipid peroxidation cell death pathway, holds unique implications for the antioxidant defense system, with possible contributions to inflammation. This exploration focuses on the dynamic interplay between ferroptosis and the host defense against viruses, emphasizing the influence of IFV infections on the activation of the ferroptosis pathway. IFV causes different types of cell death, including apoptosis, necrosis, and ferroptosis. IFV-induced ferroptotic cell death is mediated by alterations in iron homeostasis, intensifying the accumulation of reactive oxygen species and promoting lipid peroxidation. A comprehensive investigation into the mechanism of ferroptosis in viral infections, specifically IFV, has great potential to identify therapeutic strategies. This understanding may pave the way for the development of drugs using ferroptosis inhibitors, presenting an effective approach to suppress viral infections.
Keywords: Cell death; Ferroptosis; Inflammation; Influenza virus; Lipid peroxidation; Oxidative stress.