tetano
Editor, Senior Moderator
Virol J
. 2025 Mar 4;22(1):57.
doi: 10.1186/s12985-025-02653-6. Unique skin nodules following COVID-19 vaccination: a case report of cutaneous plasmacytosis and review of the literature
Xiaoxi Xu[SUP] #[/SUP][SUP] 1 [/SUP], Wuwu Ding[SUP] #[/SUP][SUP] 2 [/SUP], Haizhen Song[SUP] 3 [/SUP], Dong Wang[SUP] 3 [/SUP]
Affiliations
Background: Cutaneous plasmacytosis (CP) is a rare disorder that may affect two or more organ systems, such as skin, lymph nodes or lungs. The pathogenesis of CP remains unknown, and in most cases, the condition follows a chronic and benign clinical course without spontaneous remission.
Case presentation: A 50-year-old male who developed necrotizing skin nodules without other systemic abnormalities four days after the first doses of the Coronavirus disease 2019 (COVID-19) vaccination. Oral prednisone improved the lesions by approximately 70%. However, signs of CP recurrence manifested 15 days after the second dose of COVID-19 vaccination. Ultimately, the patient experienced spontaneous remission after contracting SARS-CoV-2 infection.
Conclusion: This case uniquely associates COVID-19 inactivated vaccine with CP, where the same lesions appeared after two vaccinations and subsequently resolved following SARS-CoV-2 infection. This provides valuable clinical data for future studies on viral infections and cutaneous B-cell immunity.
Keywords: COVID-19 vaccine; Cutaneous immunity; Cutaneous plasmacytosis; IL-6; Immune tolerance; Skin adverse reactions.
. 2025 Mar 4;22(1):57.
doi: 10.1186/s12985-025-02653-6. Unique skin nodules following COVID-19 vaccination: a case report of cutaneous plasmacytosis and review of the literature
Xiaoxi Xu[SUP] #[/SUP][SUP] 1 [/SUP], Wuwu Ding[SUP] #[/SUP][SUP] 2 [/SUP], Haizhen Song[SUP] 3 [/SUP], Dong Wang[SUP] 3 [/SUP]
Affiliations
- PMID: 40038708
- PMCID: PMC11877820
- DOI: 10.1186/s12985-025-02653-6
Background: Cutaneous plasmacytosis (CP) is a rare disorder that may affect two or more organ systems, such as skin, lymph nodes or lungs. The pathogenesis of CP remains unknown, and in most cases, the condition follows a chronic and benign clinical course without spontaneous remission.
Case presentation: A 50-year-old male who developed necrotizing skin nodules without other systemic abnormalities four days after the first doses of the Coronavirus disease 2019 (COVID-19) vaccination. Oral prednisone improved the lesions by approximately 70%. However, signs of CP recurrence manifested 15 days after the second dose of COVID-19 vaccination. Ultimately, the patient experienced spontaneous remission after contracting SARS-CoV-2 infection.
Conclusion: This case uniquely associates COVID-19 inactivated vaccine with CP, where the same lesions appeared after two vaccinations and subsequently resolved following SARS-CoV-2 infection. This provides valuable clinical data for future studies on viral infections and cutaneous B-cell immunity.
Keywords: COVID-19 vaccine; Cutaneous immunity; Cutaneous plasmacytosis; IL-6; Immune tolerance; Skin adverse reactions.