tetano
Editor, Senior Moderator
Virol J
. 2023 Nov 27;20(1):276.
doi: 10.1186/s12985-023-02222-9. Susceptibility of bovine to SARS-CoV-2 variants of concern: insights from ACE2, AXL, and NRP1 receptors
Ying Ma[SUP] 1 [/SUP], Mengyue Lei[SUP] 1 [/SUP], Hongli Chen[SUP] 1 2 [/SUP], Pu Huang[SUP] 1 [/SUP], Jing Sun[SUP] 3 [/SUP], Qiangming Sun[SUP] 4 [/SUP], Yunzhang Hu[SUP] 5 [/SUP], Jiandong Shi[SUP] 6 7 [/SUP]
Affiliations
The possibilities of cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) between humans and important livestock species are not yet known. Herein, we used the structural and genetic alignment and surface potential analysis of the amino acid (aa) in angiotensin-converting enzyme 2 (ACE2), tyrosine kinase receptor UFO (AXL), and neuropilin 1 (NRP1) in different species with substantial public health importance. The residues interfacing with the N-terminal domain (NTD) or receptor-binding domain (RBD) of S were aligned to screen the critical aa sites that determined the susceptibility of the SARS-CoV-2 to the host. We found that AXL and NRP1 proteins might be used as the receptors of SARS-CoV-2 in bovines. However, ACE2 protein may not be considered to be involved in the cross-species transmission of SARS-CoV-2 VOCs in cattle because the key residues of the ACE2-S-binding interface were different from those in known susceptible species. This study indicated that emerging SARS-CoV-2 variants potentially expand species tropism to bovines through AXL and NRP1 proteins.
Keywords: ACE2; AXL; Cross-species transmission; NRP1; Receptor; SARS-CoV-2 variants.
. 2023 Nov 27;20(1):276.
doi: 10.1186/s12985-023-02222-9. Susceptibility of bovine to SARS-CoV-2 variants of concern: insights from ACE2, AXL, and NRP1 receptors
Ying Ma[SUP] 1 [/SUP], Mengyue Lei[SUP] 1 [/SUP], Hongli Chen[SUP] 1 2 [/SUP], Pu Huang[SUP] 1 [/SUP], Jing Sun[SUP] 3 [/SUP], Qiangming Sun[SUP] 4 [/SUP], Yunzhang Hu[SUP] 5 [/SUP], Jiandong Shi[SUP] 6 7 [/SUP]
Affiliations
- PMID: 38012648
- DOI: 10.1186/s12985-023-02222-9
The possibilities of cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) between humans and important livestock species are not yet known. Herein, we used the structural and genetic alignment and surface potential analysis of the amino acid (aa) in angiotensin-converting enzyme 2 (ACE2), tyrosine kinase receptor UFO (AXL), and neuropilin 1 (NRP1) in different species with substantial public health importance. The residues interfacing with the N-terminal domain (NTD) or receptor-binding domain (RBD) of S were aligned to screen the critical aa sites that determined the susceptibility of the SARS-CoV-2 to the host. We found that AXL and NRP1 proteins might be used as the receptors of SARS-CoV-2 in bovines. However, ACE2 protein may not be considered to be involved in the cross-species transmission of SARS-CoV-2 VOCs in cattle because the key residues of the ACE2-S-binding interface were different from those in known susceptible species. This study indicated that emerging SARS-CoV-2 variants potentially expand species tropism to bovines through AXL and NRP1 proteins.
Keywords: ACE2; AXL; Cross-species transmission; NRP1; Receptor; SARS-CoV-2 variants.