tetano
Editor, Senior Moderator
Virol J
. 2023 Feb 25;20(1):37.
doi: 10.1186/s12985-023-01996-2.
Insights into organoid-based modeling of COVID-19 pathology
Mohadese Hashem Boroojerdi[SUP] 1 [/SUP], Tariq Al Jabry[SUP] 2 [/SUP], Seyed Mohamad Javad Mirarefin[SUP] 3 [/SUP], Halima Albalushi[SUP] 4 [/SUP]
Affiliations
Abstract
Since December 2019, various types of strategies have been applied due to the emergent need to investigate the biology and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to discover a functional treatment. Different disease modeling systems, such as mini-organ technology, have been used to improve our understanding of SARS-CoV-2 physiology and pathology. During the past 2 years, regenerative medicine research has shown the supportive role of organoid modeling in controlling coronavirus disease 2019 (COVID-19) through optimal drug and therapeutic approach improvement. Here, we overview some efforts that have been made to study SARS-CoV-2 by mimicking COVID-19 using stem cells. In addition, we summarize a perspective of drug development in COVID-19 treatment via organoid-based studies.
Keywords: COVID-19; Organoid; Regenerative medicine; SARS-CoV-2; Stem cell.
. 2023 Feb 25;20(1):37.
doi: 10.1186/s12985-023-01996-2.
Insights into organoid-based modeling of COVID-19 pathology
Mohadese Hashem Boroojerdi[SUP] 1 [/SUP], Tariq Al Jabry[SUP] 2 [/SUP], Seyed Mohamad Javad Mirarefin[SUP] 3 [/SUP], Halima Albalushi[SUP] 4 [/SUP]
Affiliations
- PMID: 36841795
- DOI: 10.1186/s12985-023-01996-2
Abstract
Since December 2019, various types of strategies have been applied due to the emergent need to investigate the biology and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to discover a functional treatment. Different disease modeling systems, such as mini-organ technology, have been used to improve our understanding of SARS-CoV-2 physiology and pathology. During the past 2 years, regenerative medicine research has shown the supportive role of organoid modeling in controlling coronavirus disease 2019 (COVID-19) through optimal drug and therapeutic approach improvement. Here, we overview some efforts that have been made to study SARS-CoV-2 by mimicking COVID-19 using stem cells. In addition, we summarize a perspective of drug development in COVID-19 treatment via organoid-based studies.
Keywords: COVID-19; Organoid; Regenerative medicine; SARS-CoV-2; Stem cell.