tetano
Editor, Senior Moderator
Virol J
. 2020 Dec 10;17(1):193.
doi: 10.1186/s12985-020-01461-4.
Comparative analysis of clinical features of SARS-CoV-2 and adenovirus infection among children
Kuanrong Li[SUP] 1 [/SUP], Ling Li[SUP] 1 [/SUP], Xianfeng Wang[SUP] 2 [/SUP], Hui Li[SUP] 3 [/SUP], Jun Chen[SUP] 2 [/SUP], Lei Liu[SUP] 4 [/SUP], Jianbo Shao[SUP] 3 [/SUP], Yi Xu[SUP] 5 [/SUP], Liya He[SUP] 5 6 [/SUP], Sitang Gong[SUP] 5 6 [/SUP], Huimin Xia[SUP] 1 6 [/SUP], Huiying Liang[SUP] 7 [/SUP]
Affiliations
Abstract
Background: The new emerging coronavirus disease 2019 (COVID-19) overall shares similar symptoms with other common respiratory viral infections. We aimed in this study to compare COVID-19 and human adenovirus (HAdV) infections in pediatric patients regarding the frequencies of major clinical symptoms and the potential disparities in laboratory and imaging parameters.
Methods: Following a case-control-like design, we built 72 age-matched pediatric COVID-19 and HAdV patient pairs. Their early symptoms and laboratory and imaging characteristics were then retrieved and compared.
Results: Fever and cough were the most common symptoms for both infections but were seen more often in HAdV than in COVID-19 patients (92% vs. 66% and 60% vs. 18%, respectively). Compared with COVID-19 patients, children with HAdV infection had statistically significantly higher values of neutrophil count, neutrophil percentage, activated partial thromboplastin time, prothrombin time, lactate dehydrogenase, C-reactive protein, procalcitonin but lower values of lymphocyte percentage, total bilirubin, potassium and sodium. Thoracic computed tomography also revealed more anomalies in HAdV patients than in COVID-19 patients (95% vs. 67%).
Conclusions: COVID-19 is an overall less symptomatic and less severe infection at admission compared to HAdV respiratory infection in pediatric population.
Keywords: Adenoviruses; COVID-19; Children; Respiratory infections; SARS-CoV-2.
. 2020 Dec 10;17(1):193.
doi: 10.1186/s12985-020-01461-4.
Comparative analysis of clinical features of SARS-CoV-2 and adenovirus infection among children
Kuanrong Li[SUP] 1 [/SUP], Ling Li[SUP] 1 [/SUP], Xianfeng Wang[SUP] 2 [/SUP], Hui Li[SUP] 3 [/SUP], Jun Chen[SUP] 2 [/SUP], Lei Liu[SUP] 4 [/SUP], Jianbo Shao[SUP] 3 [/SUP], Yi Xu[SUP] 5 [/SUP], Liya He[SUP] 5 6 [/SUP], Sitang Gong[SUP] 5 6 [/SUP], Huimin Xia[SUP] 1 6 [/SUP], Huiying Liang[SUP] 7 [/SUP]
Affiliations
- PMID: 33302983
- PMCID: PMC7726278
- DOI: 10.1186/s12985-020-01461-4
Abstract
Background: The new emerging coronavirus disease 2019 (COVID-19) overall shares similar symptoms with other common respiratory viral infections. We aimed in this study to compare COVID-19 and human adenovirus (HAdV) infections in pediatric patients regarding the frequencies of major clinical symptoms and the potential disparities in laboratory and imaging parameters.
Methods: Following a case-control-like design, we built 72 age-matched pediatric COVID-19 and HAdV patient pairs. Their early symptoms and laboratory and imaging characteristics were then retrieved and compared.
Results: Fever and cough were the most common symptoms for both infections but were seen more often in HAdV than in COVID-19 patients (92% vs. 66% and 60% vs. 18%, respectively). Compared with COVID-19 patients, children with HAdV infection had statistically significantly higher values of neutrophil count, neutrophil percentage, activated partial thromboplastin time, prothrombin time, lactate dehydrogenase, C-reactive protein, procalcitonin but lower values of lymphocyte percentage, total bilirubin, potassium and sodium. Thoracic computed tomography also revealed more anomalies in HAdV patients than in COVID-19 patients (95% vs. 67%).
Conclusions: COVID-19 is an overall less symptomatic and less severe infection at admission compared to HAdV respiratory infection in pediatric population.
Keywords: Adenoviruses; COVID-19; Children; Respiratory infections; SARS-CoV-2.