tetano
Editor, Senior Moderator
Virol J
. 2023 Jun 1;20(1):109.
doi: 10.1186/s12985-023-02081-4. Causal associations between chronic hepatitis B and COVID-19 in East Asian populations
Zhenguo Liu[SUP] #[/SUP][SUP] 1 [/SUP], Linnan Song[SUP] #[/SUP][SUP] 1 [/SUP], Junling Chen[SUP] 1 [/SUP], Yongjun Zhou[SUP] 1 [/SUP], Yuhao Wang[SUP] 1 [/SUP], Libo Tang[SUP] 2 [/SUP], Yongyin Li[SUP] 3 [/SUP]
Affiliations
Background: The relationship between chronic hepatitis B (CHB) and Coronavirus disease 2019 (COVID-19) has been inconsistent in traditional observational studies.
Methods: We explored the total causal and direct causal associations between CHB and the three COVID-19 outcomes using univariate and multivariate Mendelian randomization (MR) analyses, respectively. Genome-wide association study datasets for CHB and COVID-19 were obtained from the Japan Biobank and the COVID-19 Host Genetics Initiative, respectively.
Results: Univariate MR analysis showed that CHB increased the risk of SARS-CoV-2 infection (OR = 1.04, 95% CI 1.01-1.07, P = 3.39E-03), hospitalized COVID-19 (OR = 1.10, 95% CI 1.06-1.13, P = 7.31E-08), and severe COVID-19 (OR = 1.16, 95%CI 1.08-1.26, P = 1.43E-04). A series of subsequent sensitivity analyses ensured the stability and reliability of these results. In multivariable MR analyses adjusting for type 2 diabetes, body mass index, basophil count, and smoking, genetically related CHB is still positively associated with increased risk of SARS-CoV-2 infection (OR = 1.06, 95% CI 1.02-1.11, P = 1.44E-03) and hospitalized COVID-19 (OR = 1.12, 95% CI 1.07-1.16, P = 5.13E-07). However, the causal link between CHB and severe COVID-19 was attenuated after adjustment for the above variables. In addition, the MR analysis did not support the causal effect of COVID-19 on CHB.
Conclusions: This study provides evidence that CHB increases COVID-19 susceptibility and severity among individuals of East Asian ancestry.
Keywords: Causal effect; Chronic hepatitis B (CHB); Coronavirus disease 2019 (COVID-19); Mendelian randomization (MR).
. 2023 Jun 1;20(1):109.
doi: 10.1186/s12985-023-02081-4. Causal associations between chronic hepatitis B and COVID-19 in East Asian populations
Zhenguo Liu[SUP] #[/SUP][SUP] 1 [/SUP], Linnan Song[SUP] #[/SUP][SUP] 1 [/SUP], Junling Chen[SUP] 1 [/SUP], Yongjun Zhou[SUP] 1 [/SUP], Yuhao Wang[SUP] 1 [/SUP], Libo Tang[SUP] 2 [/SUP], Yongyin Li[SUP] 3 [/SUP]
Affiliations
- PMID: 37264390
- DOI: 10.1186/s12985-023-02081-4
Background: The relationship between chronic hepatitis B (CHB) and Coronavirus disease 2019 (COVID-19) has been inconsistent in traditional observational studies.
Methods: We explored the total causal and direct causal associations between CHB and the three COVID-19 outcomes using univariate and multivariate Mendelian randomization (MR) analyses, respectively. Genome-wide association study datasets for CHB and COVID-19 were obtained from the Japan Biobank and the COVID-19 Host Genetics Initiative, respectively.
Results: Univariate MR analysis showed that CHB increased the risk of SARS-CoV-2 infection (OR = 1.04, 95% CI 1.01-1.07, P = 3.39E-03), hospitalized COVID-19 (OR = 1.10, 95% CI 1.06-1.13, P = 7.31E-08), and severe COVID-19 (OR = 1.16, 95%CI 1.08-1.26, P = 1.43E-04). A series of subsequent sensitivity analyses ensured the stability and reliability of these results. In multivariable MR analyses adjusting for type 2 diabetes, body mass index, basophil count, and smoking, genetically related CHB is still positively associated with increased risk of SARS-CoV-2 infection (OR = 1.06, 95% CI 1.02-1.11, P = 1.44E-03) and hospitalized COVID-19 (OR = 1.12, 95% CI 1.07-1.16, P = 5.13E-07). However, the causal link between CHB and severe COVID-19 was attenuated after adjustment for the above variables. In addition, the MR analysis did not support the causal effect of COVID-19 on CHB.
Conclusions: This study provides evidence that CHB increases COVID-19 susceptibility and severity among individuals of East Asian ancestry.
Keywords: Causal effect; Chronic hepatitis B (CHB); Coronavirus disease 2019 (COVID-19); Mendelian randomization (MR).