GSGS and I have been having a conversation about the high degree of reassortment/co-infections we've seen in this new H7N9. Wondering about the different ways these may happen.
We both did some research to see if the cells needed for replication died immediately upon the death of the bird/human. Any speculation that 2 viruses could replicate in a dead bird was probably put to rest.
I'm always surprised at the amount of reassortments we have in humans; what are the odds that one entity can have 2 different introductions at basically the same time and those go on to create a successful strain?
Here are his comments on autolysis:
http://en.wikipedia.org/wiki/Autolysis_(biology)
"when breathing stops, the cells accumulate CO2 and PH2 changes
and metabolism changes. Hard to imagine that the cell could
create the virus proteins without oxygen under these circumstances
even if autolysis is slower in the lungs
the virus needs 6 hours
but maybe all the mixing of dead chicken organs can create mechanically
droplets with different viruses and then infected chickens often get co-infections."
We would appreciate hearing others' thoughts on this.
We both did some research to see if the cells needed for replication died immediately upon the death of the bird/human. Any speculation that 2 viruses could replicate in a dead bird was probably put to rest.
I'm always surprised at the amount of reassortments we have in humans; what are the odds that one entity can have 2 different introductions at basically the same time and those go on to create a successful strain?
Here are his comments on autolysis:
http://en.wikipedia.org/wiki/Autolysis_(biology)
"when breathing stops, the cells accumulate CO2 and PH2 changes
and metabolism changes. Hard to imagine that the cell could
create the virus proteins without oxygen under these circumstances
even if autolysis is slower in the lungs
the virus needs 6 hours
but maybe all the mixing of dead chicken organs can create mechanically
droplets with different viruses and then infected chickens often get co-infections."
We would appreciate hearing others' thoughts on this.
