tetano
Editor, Senior Moderator
BMC Infect Dis. 2015 Feb 22;15(1):87. doi: 10.1186/s12879-015-0806-2.
[h=1]Viral infections in outpatients with medically attended acute respiratory illness during the 2012-2013 influenza season.[/h] Zimmerman RK[SUP]1[/SUP], Rinaldo CR[SUP]2,[/SUP][SUP]3[/SUP], Nowalk MP[SUP]4[/SUP], Balasubramani GK[SUP]5[/SUP], Moehling KK[SUP]6[/SUP], Bullotta A[SUP]7[/SUP], Eng HF[SUP]8[/SUP], Raviotta JM[SUP]9[/SUP], Sax TM[SUP]10[/SUP], Wisniewski S[SUP]11[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] While it is known that acute respiratory illness (ARI) is caused by an array of viruses, less is known about co-detections and the resultant comparative symptoms and illness burden. This study examined the co-detections, the distribution of viruses, symptoms, and illness burden associated with ARI between December 2012 and March 2013.
[h=4]METHODS:[/h] Outpatients with ARI were assayed for presence of 18 viruses using multiplex reverse transcriptase polymerase chain reaction (MRT-PCR) to simultaneously detect multiple viruses.
[h=4]RESULTS:[/h] Among 935 patients, 60% tested positive for a single virus, 9% tested positive for ≥1 virus and 287 (31%) tested negative. Among children (<18 years), the respective distributions were 63%, 14%, and 23%; whereas for younger adults (18-49 years), the distributions were 58%, 8%, and 34% and for older adults (≥50 years) the distributions were 61%, 5%, and 32% (P < 0.001). Co-detections were more common in children than older adults (P = 0.01), and less frequent in households without children (P = 0.003). Most frequently co-detected viruses were coronavirus, respiratory syncytial virus, and influenza A virus. Compared with single viral infections, those with co-detections less frequently reported sore throat (P = 0.01), missed fewer days of school (1.1 vs. 2 days; P = 0.04), or work (2 vs. 3 days; P = 0.03); other measures of illness severity did not vary.
[h=4]CONCLUSIONS:[/h] Among outpatients with ARI, 69% of visits were associated with a viral etiology. Co-detections of specific clusters of viruses were observed in 9% of ARI cases particularly in children, were less frequent in households without children, and were less symptomatic (e.g., lower fever) than single infections.
PMID: 25887948 [PubMed - in process] PMCID: PMC4344779
[h=1]Viral infections in outpatients with medically attended acute respiratory illness during the 2012-2013 influenza season.[/h] Zimmerman RK[SUP]1[/SUP], Rinaldo CR[SUP]2,[/SUP][SUP]3[/SUP], Nowalk MP[SUP]4[/SUP], Balasubramani GK[SUP]5[/SUP], Moehling KK[SUP]6[/SUP], Bullotta A[SUP]7[/SUP], Eng HF[SUP]8[/SUP], Raviotta JM[SUP]9[/SUP], Sax TM[SUP]10[/SUP], Wisniewski S[SUP]11[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] While it is known that acute respiratory illness (ARI) is caused by an array of viruses, less is known about co-detections and the resultant comparative symptoms and illness burden. This study examined the co-detections, the distribution of viruses, symptoms, and illness burden associated with ARI between December 2012 and March 2013.
[h=4]METHODS:[/h] Outpatients with ARI were assayed for presence of 18 viruses using multiplex reverse transcriptase polymerase chain reaction (MRT-PCR) to simultaneously detect multiple viruses.
[h=4]RESULTS:[/h] Among 935 patients, 60% tested positive for a single virus, 9% tested positive for ≥1 virus and 287 (31%) tested negative. Among children (<18 years), the respective distributions were 63%, 14%, and 23%; whereas for younger adults (18-49 years), the distributions were 58%, 8%, and 34% and for older adults (≥50 years) the distributions were 61%, 5%, and 32% (P < 0.001). Co-detections were more common in children than older adults (P = 0.01), and less frequent in households without children (P = 0.003). Most frequently co-detected viruses were coronavirus, respiratory syncytial virus, and influenza A virus. Compared with single viral infections, those with co-detections less frequently reported sore throat (P = 0.01), missed fewer days of school (1.1 vs. 2 days; P = 0.04), or work (2 vs. 3 days; P = 0.03); other measures of illness severity did not vary.
[h=4]CONCLUSIONS:[/h] Among outpatients with ARI, 69% of visits were associated with a viral etiology. Co-detections of specific clusters of viruses were observed in 9% of ARI cases particularly in children, were less frequent in households without children, and were less symptomatic (e.g., lower fever) than single infections.
PMID: 25887948 [PubMed - in process] PMCID: PMC4344779