tetano
Editor, Senior Moderator
Viral Immunol
. 2024 Mar;37(2):79-88.
doi: 10.1089/vim.2023.0097. Research Progress on the Weak Immune Response to the COVID-19 Vaccine in Patients with Type 2 Diabetes
Shiqi Yuan[SUP] 1 [/SUP], Wenwen He[SUP] 1 [/SUP], Bin Liu[SUP] 1 [/SUP], Zhuoran Liu[SUP] 1 [/SUP]
Affiliations
Coronavirus Disease 2019 (COVID-19) is generally susceptible to the population, highly infectious, rapidly transmitted, and highly fatal. There is a lack of specific drugs against the virus at present and vaccination is the most effective strategy to prevent infection. However, studies have found that some groups, particularly patients with diabetes, show varying degrees of weak immune reactivity to various COVID-19 vaccines, resulting in poor preventive efficacy against the novel coronavirus in patients with diabetes. Therefore, in this study, patients with type 2 diabetes mellitus (T2DM) who had weak immune response to the COVID-19 vaccine in recent years were analyzed. This article reviews the phenomenon, preliminary mechanism, and related factors affecting weak vaccine response in patients with T2DM, which is expected to help in the development of new vaccines for high-risk groups for COVID-19.
Keywords: COVID-19; immune disorder; immune response; review; type 2 diabetes mellitus; vaccine.
. 2024 Mar;37(2):79-88.
doi: 10.1089/vim.2023.0097. Research Progress on the Weak Immune Response to the COVID-19 Vaccine in Patients with Type 2 Diabetes
Shiqi Yuan[SUP] 1 [/SUP], Wenwen He[SUP] 1 [/SUP], Bin Liu[SUP] 1 [/SUP], Zhuoran Liu[SUP] 1 [/SUP]
Affiliations
- PMID: 38498797
- DOI: 10.1089/vim.2023.0097
Coronavirus Disease 2019 (COVID-19) is generally susceptible to the population, highly infectious, rapidly transmitted, and highly fatal. There is a lack of specific drugs against the virus at present and vaccination is the most effective strategy to prevent infection. However, studies have found that some groups, particularly patients with diabetes, show varying degrees of weak immune reactivity to various COVID-19 vaccines, resulting in poor preventive efficacy against the novel coronavirus in patients with diabetes. Therefore, in this study, patients with type 2 diabetes mellitus (T2DM) who had weak immune response to the COVID-19 vaccine in recent years were analyzed. This article reviews the phenomenon, preliminary mechanism, and related factors affecting weak vaccine response in patients with T2DM, which is expected to help in the development of new vaccines for high-risk groups for COVID-19.
Keywords: COVID-19; immune disorder; immune response; review; type 2 diabetes mellitus; vaccine.