tetano
Editor, Senior Moderator
Viral Immunol
. 2024 Dec 5.
doi: 10.1089/vim.2024.0076. Online ahead of print. Maintenance of Long-Term Effective Humoral Immune Response in Patients with COVID-19 with Homologous or Heterologous Booster Vaccines: A Retrospective Study
Xin Zhang[SUP] 1 2 [/SUP], Li Li[SUP] 3 4 [/SUP], Yongmei Liu[SUP] 5 [/SUP], Haoting Zhan[SUP] 5 [/SUP], Muwei Dai[SUP] 6 [/SUP], Kun Zhang[SUP] 7 [/SUP], Huimin Yan[SUP] 8 [/SUP], Huixia Gao[SUP] 9 [/SUP], Jingwen Liu[SUP] 10 [/SUP], Shifu Liu[SUP] 2 [/SUP], Weina Lu[SUP] 7 [/SUP], Yongzhe Li[SUP] 5 [/SUP], Aidong Feng[SUP] 7 [/SUP], Erhei Dai[SUP] 3 9 [/SUP], Junying Zhou[SUP] 1 [/SUP]
Affiliations
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and first identified in Wuhan, China, in December 2019, has led to global efforts in vaccination to mitigate rising morbidity and mortality, with vaccines proving crucial in controlling the pandemic. This study evaluated the humoral responses to the inactivated virus vaccine Sinopharm or Koxing Kerlafor, the protein subunit vaccine ZF001, and the adenoviral vector vaccine Convidecia after 18 months of inactivated virus vaccination by heterologous and homologous booster vaccination in patients with previous SARS-CoV-2 infection and healthy individuals. We discovered that patients who had recovered from the infection and then received a third vaccine dose (booster) exhibited durable immunity. Furthermore, the heterologous booster vaccine induced higher neutralizing antibody responses compared with the homologous booster. These findings offer valuable insights into the efficacy of different COVID-19 vaccine strategies following booster immunization.
Keywords: COVID-19; SARS-COV-2; antibodies; heterologous booster vaccines.
. 2024 Dec 5.
doi: 10.1089/vim.2024.0076. Online ahead of print. Maintenance of Long-Term Effective Humoral Immune Response in Patients with COVID-19 with Homologous or Heterologous Booster Vaccines: A Retrospective Study
Xin Zhang[SUP] 1 2 [/SUP], Li Li[SUP] 3 4 [/SUP], Yongmei Liu[SUP] 5 [/SUP], Haoting Zhan[SUP] 5 [/SUP], Muwei Dai[SUP] 6 [/SUP], Kun Zhang[SUP] 7 [/SUP], Huimin Yan[SUP] 8 [/SUP], Huixia Gao[SUP] 9 [/SUP], Jingwen Liu[SUP] 10 [/SUP], Shifu Liu[SUP] 2 [/SUP], Weina Lu[SUP] 7 [/SUP], Yongzhe Li[SUP] 5 [/SUP], Aidong Feng[SUP] 7 [/SUP], Erhei Dai[SUP] 3 9 [/SUP], Junying Zhou[SUP] 1 [/SUP]
Affiliations
- PMID: 39635888
- DOI: 10.1089/vim.2024.0076
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and first identified in Wuhan, China, in December 2019, has led to global efforts in vaccination to mitigate rising morbidity and mortality, with vaccines proving crucial in controlling the pandemic. This study evaluated the humoral responses to the inactivated virus vaccine Sinopharm or Koxing Kerlafor, the protein subunit vaccine ZF001, and the adenoviral vector vaccine Convidecia after 18 months of inactivated virus vaccination by heterologous and homologous booster vaccination in patients with previous SARS-CoV-2 infection and healthy individuals. We discovered that patients who had recovered from the infection and then received a third vaccine dose (booster) exhibited durable immunity. Furthermore, the heterologous booster vaccine induced higher neutralizing antibody responses compared with the homologous booster. These findings offer valuable insights into the efficacy of different COVID-19 vaccine strategies following booster immunization.
Keywords: COVID-19; SARS-COV-2; antibodies; heterologous booster vaccines.