tetano
Editor, Senior Moderator
J Gen Virol. 2014 Feb 28. doi: 10.1099/vir.0.062836-0. [Epub ahead of print]
Viral determinants of influenza A host range.
Cauldwell AV1, Long JS, Moncorg? O, Barclay WS.
Author information
Abstract
Typical avian influenza A viruses are restricted from replicating efficiently and causing disease in humans. However, an avian virus can become adapted to humans by mutating or recombining with currently circulating human viruses. These viruses have the potential to cause pandemics in an immunologically na?ve human population. It is critical that we understand the molecular basis of host range restriction and how this can be overcome. Here we review our current understanding of the mechanisms by which influenza viruses adapt to replicate efficiently in a new host. We predominantly focus on the influenza polymerase which remains one of the least understood host range barriers.
KEYWORDS:
host range, influenza, polymerase
PMID:
24584475
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24584475
Viral determinants of influenza A host range.
Cauldwell AV1, Long JS, Moncorg? O, Barclay WS.
Author information
Abstract
Typical avian influenza A viruses are restricted from replicating efficiently and causing disease in humans. However, an avian virus can become adapted to humans by mutating or recombining with currently circulating human viruses. These viruses have the potential to cause pandemics in an immunologically na?ve human population. It is critical that we understand the molecular basis of host range restriction and how this can be overcome. Here we review our current understanding of the mechanisms by which influenza viruses adapt to replicate efficiently in a new host. We predominantly focus on the influenza polymerase which remains one of the least understood host range barriers.
KEYWORDS:
host range, influenza, polymerase
PMID:
24584475
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24584475