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Viet Nam - Quang Ngai: Undiagnosed illness, 26 fatalities since April 2011

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- spread to Thailand discarded- rickettsia identified

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- spread to Thailand discarded- rickettsia identified

Orientia tsutsugamushi



http://en.wikipedia.org/wiki/Scrub_typhus
http://wwwnc.cdc.gov/eid/article/12/7/05-0827_article.htm

http://wwwnc.cdc.gov/eid/article/12/2/pdfs/05-0967.pdf

Scrub typhus is typically a nonspecific febrile illness;
its severity may be influenced by the strain of O. tsutsugamushi,
a person’s immune status, and other factors
Diagnosis may be complicated in areas where the disease
has not been documented recently or in regions lacking the
capacity for laboratory confirmation. Illness develops after
an incubation period of 6 to 21 days and usually begins
with an eschar at the site of a chigger bite. Fever,
headache, and myalgias are common, and a maculopapular
rash may also be present. Nausea, vomiting, diarrhea, or
lower respiratory symptoms can also occur. Manifestations
such as pneumonitis, meningoencephalitis, jaundice, renal
failure, and myocarditis can develop during the prolonged
clinical course of untreated illness
(6). Establishing the
diagnosis and initiating prompt antimicrobial drug therapy
are important because death rates for untreated scrub
typhus patients are 1%–30% (5). Scrub typhus is effectively
treated with doxycycline, and treatment should begin
immediately upon suspicion of illness without awaiting
laboratory confirmation.

From October 2001 to October 2003, an outbreak of
scrub typhus was confirmed among residents of the
Republic of Palau, a Pacific island nation 900 km east of
the Philippines (Figure 1). The outbreak occurred among
residents of several remote southwest islands (7). These
islands, ≈300 km from the capital of Koror, are difficult to
reach, and affected persons required emergency evacuation
by boat to Koror for treatment. This outbreak affected
primarily children,
and illness was characterized by fever
and severe abdominal distress (7).
 
Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- spread to Thailand discarded- rickettsia identified

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- spread to Thailand discarded- rickettsia identified

http://www.mysinchew.com/node/72895

Mysterious skin disease in central Vietnam identified
Foreign 2012-04-25 15:51
HANOI, April 25 (Xinhua) -- According to Quang Ngai provincial health department, the mysterious skin disease which left 19 dead among the province is identified.

Fourteen out of 26 blood samples from patients with a mysterious skin disease in Vietnam's central province of Quang Ngai (some 730 kilometers south of the capital Hanoi) have tested positive for the Rickettsia Virus, said Pham Hong Phuong, director of Quang Ngai provincial health department, local newspaper Vietnam News reported Wednesday.

The virus is transferred from animals to people by lice or fleas, So far, 172 people have been infected with the virus and 19 victims in the province's rural communes have been reported dead.

According to the report, the department has asked the province to provide financial assistance to equip medical facilities with blood filters and necessary medications to treat affected patients in a timely manner.

The World Health Organisation (WHO) has also said that it is ready to support the Vietnamese government in tackling the disease, but a WHO official said on Tuesday that the organization had not yet received any requests for support from the Vietnamese Ministry of Health.

The situation has turned more serious since the disease was first noticed last year. Despite the participation of several agencies, the mysterious killer still spreads out among the province.

The initial symptoms of the illness are high fever, loss of appetite and a rash on the palms and feet. If it is not treated early, the disease can affect the respiratory system, causing eye and liver problems, miscarriages and multiple organ failures, local doctors said.
 
Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- spread to Thailand discarded- rickettsia identified

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- spread to Thailand discarded- rickettsia identified

Rickettsia is a bacterial genus. There are actually several diffierent diseases caused by bacteria in this genus. Some of the more well known are spotted fever, scrub typhus, and Indian tick typhus (among many others: http://en.wikipedia.org/wiki/Rickettsia). As far as I know, they are all spread by insects. I'm not sure which rickettsial disease has been discovered as the cause of this outbreak; the articles seem to be missing this crucial detail.
 
Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- spread to Thailand discarded- rickettsia identified

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- spread to Thailand discarded- rickettsia identified

we must wait for more bacteriological details.
but knowing what it is, is a relatively good news for treatement ( antiobiotic )
 
Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- spread to Thailand discarded- rickettsia identified

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- spread to Thailand discarded- rickettsia identified

we must wait for more bacteriological details.
but knowing what it is, is a relatively good news for treatement ( antiobiotic )

I agree. Antibiotics will save lives here. Difficult to imagine it took a year to reach this diagnosis, with most of the time spent concentrating on poisoning.

Geography, which usually is an important clue to determine which agent is involved, doesn't seem to help me much here as I cannt find any previous reports of any rickettsial infections in Vietnam to compare to. Vietnam appears to be outside the regions listed in the Wikipedia article for many of the species.
 
Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

Apparently, several species have been reported from Southeast Asia before, including murine typhus, scrub typhus, and spotted fever:

http://wwwnc.cdc.gov/eid/article/12/2/pdfs/05-0900.pdf

Here's an anecdotal report of an unspecified Rickettsial infection from Hanoi from January 2012:

http://maddybackpackworld.blogspot.com/2012/01/rickettsia-in-vietnam.html

And a murine typhus case from Vietnam imported into Japan:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294741/
 
Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

This might be a clue (note no mention of ticks):

http://www.reuters.com/article/2012/04/25/vietnam-press-idUSL3E8FP19620120425

Fourteen out of 26 blood samples from patients suffering a mysterious skin disease in the central province of Quang Ngai have tested positive for the Rickettsia infection, which is transferred from animals to people by lice and fleas, Director Pham Hong Duong of the provincial health department said. So far 19 have died out of the 172 infected.
 
Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

This is on the "second" outbreak, although the two could likely be related given similar symptoms:

http://www.baomoi.com/Home/SucKhoe/vtv.vn/Them-chung-benh-sam-da-o-Quang-Ngai/8342710.epi

Add disease "tanning" in Quang Ngai



As of 24/4, Quang Ngai province had 25 cases of children from 3 months to 15 years were "tanning". In particular, three severe cases have been transferred to the provincial hospital treatment.



Photo: Newspaper Quang Ngai






The patients concentrated in two three and Son Cao Son Commune, Son Ha District with symptoms appearing several bruises on the body, mainly in the legs, arms and face. Time, these cases are communal examination of health workers, prescribe symptomatic treatment. Now, however, have not yet identified the cause of the disease.

Through the examination of the health sector Son Ha District, this is not a disease like hand dermatitis syndrome, feet occurred in the district of Ba. Initially, the district encouraged people to use safe water sources and carefully when using herbicides because these students are suspected illness due to exposure to herbicides.

Today (25/4), Quang Ngai Health Department will send medical staff to the Son Three to find out the cause, and steps taken to sample the final conclusion.

Disease "tanning" appeared in Son Ba from 04/09/2012.
 
Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

see map of distribution
in this Pdf :tiphat:, vietnam is in the triangle.
http://www.jkscience.org/archive/vo...t of Season & Life Cycle of Scrub Typhus4.pdf

Geographical Distribution, Effect of Season &
Life Cycle of Scrub Typhus

Vol. 12 No. 2, April-June 2010 www.jkscience.org
 
Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

beautifull and free.. scanner, radiology,


http://radiographics.rsna.org/content/27/1/161.full


and

http://www.annals.org/content/79/1/26.short


Scrub Typhus in South Vietnam

A Study of 87 Cases


  1. STEVEN J. BERMAN, M.D.; and
  2. WILLIAM D. KUNDIN, Ph.D.
+ Author Affiliations

  1. <address> <address>Taipei</address>, Taiwan </address>

Abstract

With the use of indirect fluorescent antibody or mouse inoculation methods, scrub typhus was diagnosed in 109 of 1650 febrile American servicemen in Vietnam. The fluorescent antibody test was positive in all 32 patients from whom rickettsia were recovered, but a rising antibody titer to Proteus OXK occurred in only 47%, which included only 5 of 27 patients infected with Gilliam strain. The diagnosis was clinically suspected in only 51 patients. Generalized lymphadenopathy and lymphocytosis were commoner than either eschar or rash, and, in the absence of the latter findings, the illness was frequently mistaken for infectious mononucleosis. Early treatment with tetracycline shortened the duration of illness and suppressed the convalescence indirect fluorescent antibody titer. No relapses occurred in those patients who received tetracycline for at least 7 days.

Article and Author Information


  • ▸From U.S. Naval Medical Research Unit No. 2, Taipei, Taiwan; the Department of Medicine, University of Washington, Seattle, Washington; and the Department of Tropical Medicine and Medical Microbiology, University of Hawaii, Honolulu, Hawaii.
  • Grant support: Work Unit M4305.12.3005, Bureau of Medicine and Surgery, Navy Department.
  • ▸Requests for reprints should be addressed to Editorial Department, NAMRU-2, Box 14, APO San Francisco 96263.
    • Received November 22, 1972.
    • Accepted March 22, 1973.
 
Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

:oops: about Orienta tsutsugamushi
Formerly classified in the genus Rickettsia, it was withdrawn on the basis of its phylogenetic classification and specific phenotypic characteristics

http://ifr48.timone.univ-mrs.fr/Fiches/Otsu.html
 
Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

http://vietnamnews.vnagency.com.vn/...eign-help-to-identify-mysterious-disease.html

Time to seek foreign help to identify mysterious disease

by Pham Diem Quynh



US ready to track down skin scourge

HCM CITY ? The US Embassy yesterday announced it stands ready to support the Vietnamese Government in tackling the mysterious skin disease that has killed several people in Quang Ngai Province.

US Embassy spokesperson Christopher Hodges made the announcement after an official from the Ministry of Health said they would seek help from the World Health Organisation and the US's Centre for Disease Control and Prevention in investigating the disease.

"Our sympathy is with those affected in Quang Ngai. We have not yet received a formal request for assistance from the Ministry of Health but stand ready to help in any way we can," Christopher said.

Meanwhile, a delegation headed by Minister of Health Nguyen Thi Kim Tien and her deputy Nguyen Thanh Long yesterday began a four-day fact finding trip to the province.

Many people have speculated that the disease could have been caused by herbicides or even toxic substances left behind during the American War. ? VNS

News of a "strange disease" in Ba To district, in the central province of Quang Ngai, has gone far beyond Viet Nam's borders.
BBC World on Saturday reported that 19 people, mostly children, had died from an unknown illness, while many others had fallen sick.

Of the 172 people that have died or fallen ill in the district by last Tuesday, 161 were from Ba Dien village. Typical symptoms are stiffness in the limbs and ulcers on the victims' hands and feet that are reminiscent of blisters. Some have also developed a serious liver disorder.

The rate of infection and re-infection has also risen dramatically over the last few weeks, leading to widespread panic, with worried parents keeping their children out of school and isolating themselves from contact with others.

Medical personnel have been advising villagers about hygiene, while they investigate the cause of the illness. Despite their actions, however, the disease has spread beyond the village.

When the illness first appeared a year ago, the ministry sent health experts to the site to collect water and soil samples, as well as blood and hair of the sick. But they could not figure it out.

Two days ago, following tests conducted by Health Ministry officials last week, the director of Quang Ngai Province's health department, Pham Hong Duong, said the rickettsia bacterium had been found in 14 out of 26 blood samples taken from patients. However, the cause of the disease has not yet been identified, Duong added.

The primitive bacterium is carried by ticks, fleas and lice, and can cause diseases such as typhus and rickettsialpox.,

Worried officials at Quang Ngai Department of Health have asked the health ministry to work with the World Health Organisation and other international institutions to investigate the cause of the disease.

The World Health Organisation said they were very concerned about the problem and ready to help Vietnamese government tackling the disease, but they had not yet received any request for help from the health ministry.

Following calls by the People's Committee of Quang Ngai Province, the Military Chemical Institute, under the Ministry of Defence, sent experts to Ba To District to investigate if water supplies and the soil contained toxic substances.

It is clear that we can't eradicate the disease until it is properly identified and named.

The practice of sacrificing buffalos to cure the illness of local Hre people will return if the disease is not quickly identified.

The health ministry should promptly seek international help with identifying the disease and its cause. Saving lives is the crucial thing here. ? VNS
 
Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

It appears Anne may have been correct as to the species of Rickettsia, but the outbreak may be more complicated than that:

http://www.thanhniennews.com/index/...ound-vietnam-skin-disease-still-unsolved.aspx

Fatal skin disease remains mystery after discovery of flea-carried bacterium
Last Updated: Thursday, April 26, 2012 05:30:00




A flea-carried bacterium has been found in blood samples taken from the patients of the skin condition that has killed 19 in central Vietnam over the past year, but local experts say it did not cause the disease.

A report on the VnExpress newswire Thursday quoted Dr. Nguyen Van Binh, chief of the Department of Preventive Health, as saying that the discovery of Ricketsia bacteria in the samples of patients ?was just initial information for experts to make a reference, because it was not the cause, just one of the factors leading to the disease.?

Earlier, on Tuesday, a delegation of experts from the Ministry of Health announced that 14 out of 26 blood samples of patients in the central province of Quang Ngai?s Ba To District tested positive with Ricketsia, which causes scrub typhus fever and is often found in fleas, lice, mites, and ticks.

According to Binh, experts are still learning about the skin condition that creates ulcers on hands and feet that look like severe burns and induce stiffness in the limbs. In critical cases, it can lead to liver and lung failure.

Health Minister Nguyen Thi Kim Tien will also make a trip to the affected areas and meet with Quang Ngai?s authorities to discuss measures for curbing the disease, the news website reported.

In the meantime, Nguyen Xuan Men, deputy director of the provincial Department of Health, proposed that the health ministry issues a new treatment protocol for the disease as the current one has proved ineffective.

Since the disease broke out last April in the province's Ba To District, 176 people in the district as well as the nearby Minh Long District have been affected, Men said, adding that 73 percent of them are farmers while 20 percent are students.

He said the disease recurred in 60 percent of the patients after treatment, and more patients were reported during the rainy season than the dry season.

The official also noted that all the patients had increases in their liver enzymes, while 20 percent of samples taken from healthy people in Ba To also had high liver enzyme function.

So far Vietnamese agencies have launched a variety of tests and inspections in the affected areas, including searching for a suspected toxin and testing water, food and earth samples.

Most experts feel the disease is not infectious and was probably caused by arsenic contamination, or some plant protection chemical, VnExpress reported
 
Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

Any reports on whether they have tested for heavy metals ?

Whilst arsenic can poison the liver, the description and pictures of the skin disease remind me of acrodynia, or pink disease, caused by inorganic mercury and primarily affecting children. Whilst you would normally expect mercury to cause kidney and neurological toxicity, there are conceivable circumstances under which it could preferentially hit the liver instead (i.e. if there were co-factors protecting kidneys and brain).
 
Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia identified

http://www.promedmail.org/

Published Date: 2012-04-27 14:37:37
Subject: PRO/EDR> Undiagnosed illness - Viet Nam (04): (QG) rickettsia susp, RFI
Archive Number: 20120427.1116144

UNDIAGNOSED ILLNESS - VIET NAM (04): (QUANG NGAI) RICKETTSIA SUSP. REQUEST FOR INFORMATION
*******************************************************************************************
A ProMED-mail post
http://www.promedmail.org
ProMED-mail is a program of the
International Society for Infectious Diseases
http://www.isid.org

Date: Wed 25 Apr 2012
Source: Quang Ngai Province website [edited]
http://www.quangngai.gov.vn/quangngai/english/news/2012/73381/


The SGGP (Sai Gon Revolution Newspaper) quoted Quang Ngai Health Department director Mr Pham Hong Phuong as saying in the evening of Tuesday (24 Apr 2012) that a rickettsia virus [rickettsia are bacteria, not viruses] was found to be the cause of the mystery disease in the mountainous district, adding that 14 out of total 26 blood sample tests on Ba Dien infected residents in Ba To district were positive for rickettsia [bacteria].

Mr Phuong said 30 per cent of the tested samples have found that erythrocytes that are small and fragile, that could have caused death in patients easily, and added that he has recently requested Quang Ngai Government to equip the provincial general hospital with ultrafiltration and special medicines to deal with the historical disease.

Quang Ngai has reported that so far at least 19 people have been killed and 172 have been injured by the disease, which is being closely watched by the Government of Viet Nam and also the World Health Organization, which has recently released information on its website to readily help Viet Nam deal with the strange disease. Currently, Quang Ngai Government has been making more efforts in providing medical and financial assistance to treating infected patients.

According to Mr Phuong, a special task delegation from the Ministry of Health (MoH) will [visit a 2nd time] the disease affected-mountainous region on 27 Apr 2012 in a bid to [determine the] causes of the skin disease.

Recently, 19 pupils in the other mountainous region of Son Ba Commune, Son Ha district, have been infected with another skin disease on hand, foot and face [?hand-foot-mouth disease] and they are under treatment in local health stations.

--
communicated by:
Viki Hansen-Landis, RN, MPH, CHES
Senior Medical Communications Specialist
Medical Information and Analysis
International SOS


[The news report above says that rickettsiae were identified in 14 of 26 blood samples. What test was used to accomplish this identification is not specified, nor is the rickettsial species specified. The _Rickettsia_ genus describes small obligate intracellular parasites that are maintained in animal and arthropod reservoirs and transmitted by arthropod vectors (ticks, fleas, lice, or mites) to humans.

Scrub typhus and murine typhus are likely the most common rickettsial diseases in Viet Nam (http://cid.oxfordjournals.org/content/34/Supplement_4/S145.full). Scrub typhus, caused by _Orientia tsutsugamushi_ , a rickettsial organism, is transmitted by bite of larval mites (chiggers), which serve as both the vector and the reservoir. Rodents of (rats and mice) are common hosts for the mites. Fever, headache, lymphadenopathy, myalgias, a sore at the site of the chigger bite, and rash that is unlike the rash described in patients in the current outbreak are common. Patients with severe scrub typhus can develop multiorgan failure and disseminated intravascular coagulopathy (DIC) with hemorrhage, with mortality rates 1-30 per cent in untreated patients.

Murine typhus is a fleaborne rickettsial disease caused by _Rickettsia typhi_. Rats are the primary animal reservoir of _R. typhi_. Humans are usually infected by contact with infected flea feces, either by inoculation into excoriated fleabites, inhalation, or ingestion. Symptoms include fever, headache, chills, vomiting, nausea, myalgias, and a rash that is unlike the rash described in patients in the current outbreak. Murine typhus usually resolves within 3 weeks, even if untreated. However up to 4 per cent of patients sick enough to be hospitalized will die from the infection.

The news report above also says that 30 per cent of the tested blood samples had erythrocytes that were small and fragile, suggesting the possibility of hemolysis, which can occur in scrub typhus with DIC. Obviously we need more information as to the way the diagnosis of rickettsial infection was made.

Quang Ngai is a Vietnamese province located in the South Central Coastal region along the South China Sea, 883 km south (549 mi) of Hanoi and 838 km (521 mi) north of Ho Chi Minh City (http://en.wikipedia.org/wiki/Quang_Ngai_province). The province has a large plain along the coast and in the center of the province and has mountains and hills in the west. Ba To is a rural district of Quang Ngai province with a population of 47 268 in 2003 (http://en.wikipedia.org/wiki/Ba_To_District).

A map of Viet Nam provinces can be seen at http://upload.wikimedia.org/wikipedia/commons/f/f0/VietnameseProvincesMap.png. Viet Nam may also be found on the interactive HealthMap/ProMED-mail map at http://healthmap.org/r/2bxT. - Mod.ML]
 
Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia suspected - scrub typhus?

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia suspected - scrub typhus?

this people could have in addition : anemia ( small erythrocytes ) or other "blood" disease ( like sickle cell anemia and thalassemia ) which are frequent in vietnam, cambdoge, and Laos

http://cid.oxfordjournals.org/content/34/Supplement_4/S145.full

Before the age of antibiotic therapy, patients with scrub typhus had high mortality rates, up to 50%?60%, with a clinical course ranging from 10 to 28 days and a protracted convalescence of up to 4 months [6, 59, 60]. It often occurs in conjunction with malaria, leptospirosis, and amebiasis. Although ∼25%?50% of scrub typhus cases occur in children, most cases occur through agricultural exposure, such as in rice field workers of Thailand, Japan, or Korea and oil palm and rubber plantation workers of Malaysia [6]. The growing popularity of ?ecotourism??camping, trekking, and rafting in areas of endemicity?has resulted in this disease being increasingly reported in European and American tourists returning home [6]. Although clear descriptions of scrub typhus are found in Chinese texts of 313 A.D., scrub (miteborne) typhus was first described in the modern literature in Japan in 1810
 
Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia suspected - scrub typhus?

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI- unspecified rickettsia suspected - scrub typhus?

Unsolved, yet again:

http://www.thanhniennews.com/index/...uspected-as-causing-fatal-skin-condition.aspx

Rice mold added to list of suspects in Vietnam fatal skin condition
Last Updated: Sunday, April 29, 2012 04:20:00


A felled tree used as a barrier to prevent people from entering Go Nghenh Village in Quang Ngai province. Villagers do not want to be disturbed while chasing away a ghost they believe is causing a skin condition that has killed at least 19 people.

Vietnam health officers are adding rice mold to the list of suspects as they try to solve the mystery of a fatal skin condition in a district in the central region.

At a Saturday meeting between the Health Ministry and authorities in Quang Ngai Province, it was said that many of the patients in Ba To District had eaten rice covered with fungus, the Nguoi Lao Dong newspaper reported.

Nguyen Thi Kim Tien, the health minister, said at the meeting that the ministry has ruled out microorganisms as the cause and narrowed the suspects to poisons transmitted through external contact or eating.

She said the condition is not contagious.

The ministry is studying the molded rice as well as other toxin suspects, and will try to reach a final conclusion in the next ten days. Otherwise, the ministry will seek help from the World Health Organization, Tien said.

The ministry’s experts last week found the flea-carried Rickettsia in half of the blood samples taken from the district on April 12-13, but then said the typhus bacterium did not cause the condition.

The skin condition begins with a high fever, loss of appetite and causes inflamed, thickened skin on palms and feet

It has thus far claimed the lives of 19 people among 179 affected in the district, including two new cases on April 28, a man and a woman both 35 years old.

Doctor Tran Hau Khang, director of Vietnam National Dermatology Hospital, said infected people, most of them children and young people, have their liver enzyme levels increase by 4-20 times the normal.

Le Han Phong, chairman of the district People’s Committee, said the illness responds well to treatment but patients who are not treated early can suffer liver problems and multi-organ failure.

The first infections in the district were reported last April. The condition died out by the year-end, but has returned with eight deaths between March 27 and April 5 this year. At least 29 people have been re-infected.

Last week the Ministry of Defense collected soil, water and air samples from the district to check if toxins left from the Vietnam War are causing the skin condition.

Meanwhile, many of the district's frightened residents have chosen to isolate themselves from outsiders, spooked by the visits of officials.

Reu and Go Nghenh villages, home to the patients, are not allowing outsiders to visit because the residents want to be undisturbed as they “make offerings to drive away the ghost causing the disease,” said Pham Van Vong, head of Go Nghenh village.

Pham Van Dang, the head of Reu village, was reluctant to open the gate to health experts.

“If they can get rid of the disease, they'd better do it. The more they came, the more people here have got sick. We are very scared now,” Dang told the Nguoi Lao Dong newspaper.
 
Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI

http://www.thanhniennews.com/index/...-half-vacant-village-as-illness-rages-on.aspx

Vietnam quarantines half-vacant village as illness rages on
Last Updated: Friday, April 27, 2012 08:10:00

World Health Organization awaits green light to assist central village after unidentified mysterious symptoms kill 19 and afflict 171 in central district

No one has been allowed in or out of Reu Village since last Thursday.

A makeshift bamboo barrier blocks every road leading to the village in Ba To District?s Ba Dien Commune and a traditional curfew, observed in times of crisis, has kept the remaining villagers confined to their homes after sundown.

Pham Van Trach, 16, lay in a hammock in his older brother?s garden. It was easy to recognize the signs of infection on his face and arms.

?I was just discharged from the hospital. My brother?s family is still at the Quy Hoa [Hospital],? he said.

The boy, who lives with his brother?s family has survived on food donated by his neighbors during the past few days.

?We are performing rituals to dispel ghosts and appeal to the Gods to help the afflicted villagers,? said Pham Van Dang, the village patriarch.

In the past three weeks, the unidentified illness has killed 19 of the roughly 170 patients in Quang Ngai Province?s Ba To District.

The illness begins with a high fever and loss of appetite. Skin inflammation, particularly on the palms and feet, soon follow.

The first case of the unidentified illness was reported on April 19, 2011. The condition seemed to die out late last year.

This spring, the village saw 68 cases and 8 deaths between March 27 and April 5.

Colonel Dinh Ngoc Tan, head of the Military Institute of Chemistry and Environmental Sciences, told reporters that Pham Van Mai, a village elder, first saw the symptoms five years ago, around the same time the villagers had buried an unknown quantity of a ?strange chemical.?

Col. Tan said Mai has given them a map to the chemical?s burial site. No further details were provided.

Meanwhile, the Quang Ngai Health Department told Vietweek on April 24 that experts from the Health Ministry are suspecting that the condition is a tick-borne disease caused by the bacteria Rickettsia.

Fourteen of the 26 blood samples taken from residents with the skin disease symptoms at Ba Dien Commune tested positive for Rickettsia, the department said.

Vietnamese health authorities have yet to offer any proper diagnosis for the condition, which re-emerged in recent weeks.

At least 29 villagers are suffering the mysterious symptoms for the second time, suggesting that some patients are unable to build up strong immunity, following the first round of infections.

Ghost town

In the past few days, many frightened villagers have relocated. Those who remain say that the residents of surrounding communities have refused to visit them.



This student is among more than 170 residents in Quang Ngai Province who are suffering from a mysterious and fatal series of symptoms that has left 19 dead.



?Last week, a villager died but few attended the funeral. They were afraid that the ghost would seize their lives as well,? said villager Pham Van Khiem.

Like Khiem and Dang, all Hre ethnic people were given the family name of Prime Minister

Pham Van Dong (1906-2000) in 1975. Traditionally, members of tribe only carried one name.

Many of the houses in the village now stand empty as families crowd into hospitals to watch over sick relatives. Others moved to surrounding villages in fear of ?ghosts.?

?We?re trying to calm them down without having an explanation,? he said. ?We know nothing about the condition.?

Dang said the illness has totally upended life in the village. Men refuse to go to the field and many children have ceased going to class.

?Everyone is afraid that they?ll contract the disease sooner or later,? he said.

Nearly 50 patients have been admitted to the Quy Hoa National Leprosy and Dermatology Hospital in neighboring Binh Dinh Province.

Nguyen Van Duong, principal of Ba Dien Secondary School, said half of the school?s pupils stopped showing up to class in recent weeks, just a few weeks before final exams.

Meanwhile, according to the commune chairman, Pham Van Hoa, only five of 75 students continue to attend the community?s only kindergarten.

?Some of these children contracted the disease but the parents of healthy kids are too afraid to take them to school,? he said, adding that many families have simply moved to other villages.

Toxin suspected

Experts from the Ministry of National Defense gathered at Ba To District in Quang Ngai Province on April 20-21 to determine the cause of the problem.

The experts interviewed locals about their diets and possible sites of contamination.

Officials from the ministry have claimed that senior residents told them that the district once housed a US arsenal. Early this week, military scientists began collecting water and soil samples. Some suspect that toxins left over from the Vietnam War may be responsible for the recent outbreak.

Le Han Phong, chairman of Ba To District People?s Committee, said that patients who do not seek medical treatment soon after symptoms emerge can eventually suffer liver problems and organ failure.

Tran Hau Khang, director of the National Dermatology Hospital in Hanoi, said that, although the illness has yet to be identified, it does not appear to be contagious.

The military experts said they will study the water and soil samples and confirm, possibly in ten days, if the condition was brought on by exposure to toxins.

Officials from the Ministry of Health visited Ba To, earlier this month, to gather skin and hair samples?they may have some test results next week.

On April 20, Deputy Health Minister Nguyen Thanh Long announced that his agency planned to seek help from the World Health Organization (WHO) and the US Center for Disease Control (USCDC).

Tarik Jasarevic, a spokesman for the WHO told Vietweek that the organization is monitoring the situation and awaiting further instruction.

?We are not aware of any reports of similar symptoms elsewhere in Vietnam? No evidence for human-to-human transmission of this disease has been presented,? he told Vietweek via email on Tuesday.

?The WHO is in contact with the Ministry of Health about this event and is ready to provide technical support if asked,? he added.

Jasarevic said WHO has yet to receive an official request from the Ministry of Health to provide assistance.
 
Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI

Re: Undiagnosed illness, 19 fatalities since April 2011 - Viet Nam: Quang Ngai, ProMED RFI

No shortage of suspects:

http://www.promedmail.org/mbds

Published Date: 2012-05-01 23:08:48
Subject: PRO/MBDS> Undiagnosed illness - Viet Nam (06): Quang Ngai, rickettsia
Archive Number: 20120501.0991

UNDIAGNOSED ILLNESS - VIET NAM (06): QUANG NGAI, RICKETTSIA SUSP.
REQUEST FOR INFORMATION
******************************************************************************************

A ProMED-mail post
http://www.promedmail.org
ProMED-mail is a program of the
International Society for Infectious Diseases
http://www.isid.org

Date: Wed 25 Apr 2012Source: Sai Gon Giai Phong Daily [edited]http://www.saigon-gpdaily.com.vn/Health/2012/4/100887/


"Rickettsia" virus identified as cause of bizarre skin disease
-----------------------------------------
The Ministry of Health has so far identified the "Rickettsia" virus as
cause of the bizarre skin disease that has afflicted residents in the
central province of Quang Ngai, said a health official on [24 Apr 2012].
Pham Hong Phuong, director of the Department of Health in Quang Ngai
Province, said that medical experts have initially identified the
Risketsia virus as cause of the baffling skin disease in Ba Dien Commune
in Ba To District.

Of 26 blood samples taken of patients, 14 tested positive for Rickettsia
virus, with 30 per cent of the samples showing small and fragile red
blood cells that could have caused death in patients.

Till [24 Apr 2012], Quang Ngai Province had reported 172 cases of the
skin disease infection, 8 of whom had died at medical clinics and 11
having died at home. The disease begins with a rash on the hands and
feet, and progresses to affect and damage the liver and subsequently
damages other body organs.

As the disease develops unpredictably, the province leaders have decided
to equip the General Hospital with a blood filtering machine for
reducing fatalities. In addition, the province will support 5 per cent
of the health insurance expenses of patients affected with this
mysterious skin disease and being treated at the Quy Hoa National
Leprosy Dermatology Hospital.

As scheduled, the ministry will send a mission team to the province on
[24 Apr 2012] to continue finding out the causes of the disease.

Meantime, another strange disease occurred in Son Ha District of Quang
Ngai Province. Many people are beginning to suffer bruises in feet,
hands and face without any clear cause. The disease has hospitalised 19
students so far. Medical workers in district centres examined and gave
drugs to the students, but the cause of the disease is yet unknown. As
of now, it is suspected to be a skin disease caused by contact with
chemical herbicides.

--
Communicated by:
PRO/MBDS
<promed-mbds@promedmail.org>

[This newswire mentions that a total of 172 people have been affected by
an undiagnosed illess in Quang Ngai. Among those, 19 people died of this
strange disease. The newswire also reports that Viet Nam Ministry of
Health identified Rickettsia as the pathological agent of the strange
disease in Quang Ngai.

Rickettsia is a genus of non-motile, Gram-negative, non-spore forming,
highly pleomorphic bacteria. The classification of Rickettsia into 3
groups (spotted fever, typhus and scrub typhus) was based on serology.
This grouping has since been confirmed by DNA sequencing. All 3 of these
contain human pathogens.

Rickettsia species are carried by many ticks, fleas and lice, and
transmitted to human during feeding or by scratching infectious feces
into the skin. Inhaling dust contaminated with dried infected lice or
flea feces may also cause infections.

Rickettsia causes diseases in humans such as typhus, rickettsialpox,
Boutonneuse fever, African tick bite fever, Rocky Mountain spotted
fever, Flinders Island spotted fever and Queensland tick typhus
(Australian Tick Typhus).

Several other tick-borne species of Rickettsia, including _Rickettsia
rickettsii_, broadly grouped under the heading "Spotted Fever Group
Rickettsia (SFGR)" have been shown to cause human infections. The
initial symptoms of tick-borne SFGR infections generally include fever,
headache, fatigue and muscle aches. A maculopapular or petechial rash
may be present, and frequently a distinctive eschar (blackened or
crusted skin) may develop at the site of a tick bite. Multiple eschars
may be present if more than one tick bite occurred, see more at
http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5504a1.htm and
http://wwwnc.cdc.gov/travel/yellowb...-infections-anaplasmosis-and-ehrlichiosis.htm.

However, the article above does not say if a specific group of
Rickettsia is identified and how a differential diagnosis was made. In
addition, another cluster of skin disease was identified in 19 students
from Son Ha district of Quang Ngai province while the etiology remains
unclear.

Following comments are borrowed from bacterial disease moderator ML who
suggested other potential causes of this strange disease:


"At one point the lesions of the hands and feet are described as
"palmoplantar keratoderma", that is, an increased keratin layer on the
skin (hyperkeratosis) of the palms and soles; (see
http://emedicine.medscape.com/article/1108406-overview#aw2aab6b).
Palmoplantar keratoderma may be inherited or acquired. Conditions that
can lead to acquired palmoplantar keratoderma include inflammatory and
reactive dermatoses such as Reiter's syndrome (arthritis, conjunctivitis
or uveitis, and urethritis that follow dysentery or chlamydial or
gonococcal genital infection) and infections, such as those due to human
papillomavirus, _Treponema pallidum_ (the bacterium that causes
syphilis), _Mycobacterium tuberculosis_, and _Mycobacterium leprae_.

"Encrusted scabies may progress to hyperkeratotic and/or crusted lesions
on palmar surfaces. Painful keratotic plaques that involved the skin
surrounding the ears, the nose, and the soles in association with
polyarthritis has been described in patients with HIV infection
(http://www.nejm.org/doi/full/10.1056/NEJM200312113492425) and
keratoderma of the palms and soles has been seen in glucan-treated
patients with AIDS (http://www.ncbi.nlm.nih.gov/pubmed/2953313).

"Arsenic exposure can lead to multiple, irregular, warty keratotic
lesions on the palms and soles, typically decades after chronic arsenic
ingestion. Exposure to certain chemicals, namely chloracnegens, has been
reported to present as palmoplantar keratoderma
(Patel S, Zirwas M,
English JC. Acquired palmoplantar keratoderma. Am J Clin Dermatol. 2007;
8(1): 1-11; abstract available at
http://www.ncbi.nlm.nih.gov/pubmed/17298101). Chloracnegens are
halogenated aromatic compounds, such as chlorinated dioxins and
polychlorinated biphenyls (PCBs). Chloracne is an acne-like eruption of
blackheads, cysts, and pustules on the face and neck, associated with
overexposure to halogenated aromatic compounds, such as chlorinated dioxins.

"The news articles say that exposure to a herbicide is suspected as the
cause of this outbreak, as the patients were affected soon after
spraying herbicides in cassava fields. The most toxic dioxin,
2,3,7,8-tetrachlorodibenzo-p-dioxin, became well known as a contaminant
of Agent Orange, a herbicide used in the Viet Nam war. Dioxins were
incriminated to have poisoned president Viktor Yushchenko of Ukraine in
2004."

PRO/MBDS would appreciate further information from knowledgeable sources
regarding this undiagnosed illness in Quang Ngai province, Viet Nam.

For a map of Viet Nam with provinces, see
http://upload.wikimedia.org/wikipedia/commons/f/f0/VietnameseProvincesMap.png.
For the interactive HealthMap/ProMED-mail map with direct links to other
outbreaks in Viet Nam and surrounding countries reported on ProMED-mail
and PRO/MBDS, see http://healthmap.org/r/008O. - Mod.QCN]
 
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