tetano
Editor, Senior Moderator
[h=1]Susceptibility to and transmission of H5N1 and H7N1 highly pathogenic avian influenza viruses in bank voles (Myodes glareolus)[/h] Aurora Romero Tejeda[SUP]1[/SUP][SUP]?[/SUP], Roberta Aiello[SUP]1[/SUP][SUP]*[/SUP][SUP]?[/SUP], Angela Salomoni[SUP]1[/SUP], Valeria Berton[SUP]1[/SUP], Marta Vascellari[SUP]2[/SUP] and Giovanni Cattoli[SUP]1[/SUP]
[SUP]1[/SUP] Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), OIE/FAO and National Reference Laboratory for Newcastle Disease and Avian Influenza, OIE Collaborating Centre for Infectious Diseases at the Human-Animal Interface, Viale dell?Universit? 10, Legnaro, Padova, 35020, Italy
[SUP]2[/SUP] Histopathology Laboratory, IZSVe, Viale dell?Universit? 10, Legnaro, Padova, 35020, Italy
For all author emails, please log on.
Veterinary Research 2015, 46:51 doi:10.1186/s13567-015-0184-1
Aurora Romero Tejeda and Roberta Aiello contributed equally to this work.
The electronic version of this article is the complete one and can be found online at: http://www.veterinaryresearch.org/content/46/1/51
[TABLE="cellpadding: 0, cellspacing: 0"]
[TR]
[TD]Received:[/TD]
[TD]13 January 2015[/TD]
[/TR]
[TR]
[TD]Accepted:[/TD]
[TD]13 April 2015[/TD]
[/TR]
[TR]
[TD]Published:[/TD]
[TD]13 May 2015[/TD]
[/TR]
[/TABLE]
? 2015 Romero Tejeda et al; licensee BioMed Central.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
[h=3]Abstract[/h] The study of influenza type A (IA) infections in wild mammals populations is a critical gap in our knowledge of how IA viruses evolve in novel hosts that could be in close contact with avian reservoir species and other wild animals. The aim of this study was to evaluate the susceptibility to infection, the nasal shedding and the transmissibility of the H7N1 and H5N1 highly pathogenic avian influenza (HPAI) viruses in the bank vole (Myodes glareolus), a wild rodent common throughout Europe and Asia. Two out of 24 H5N1-infected voles displayed evident respiratory distress, while H7N1-infected voles remained asymptomatic. Viable virus was isolated from nasal washes collected from animals infected with both HPAI viruses, and extra-pulmonary infection was confirmed in both experimental groups. Histopathological lesions were evident in the respiratory tract of infected animals, although immunohistochemistry positivity was only detected in lungs and trachea of two H7N1-infected voles. Both HPAI viruses were transmitted by direct contact, and seroconversion was confirmed in 50% and 12.5% of the asymptomatic sentinels in the H7N1 and H5N1 groups, respectively. Interestingly, viable virus was isolated from lungs and nasal washes collected from contact sentinels of both groups. The present study demonstrated that two non-rodent adapted HPAI viruses caused asymptomatic infection in bank voles, which shed high amounts of the viruses and were able to infect contact voles. Further investigations are needed to determine whether bank voles could be involved as silent hosts in the transmission of HPAI viruses to other mammals and domestic poultry.
open access
http://www.veterinaryresearch.org/content/46/1/51
- * Corresponding author: Roberta Aiello raiello@izsvenezie.it
- ? Equal contributors
[SUP]1[/SUP] Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), OIE/FAO and National Reference Laboratory for Newcastle Disease and Avian Influenza, OIE Collaborating Centre for Infectious Diseases at the Human-Animal Interface, Viale dell?Universit? 10, Legnaro, Padova, 35020, Italy
[SUP]2[/SUP] Histopathology Laboratory, IZSVe, Viale dell?Universit? 10, Legnaro, Padova, 35020, Italy
For all author emails, please log on.
Veterinary Research 2015, 46:51 doi:10.1186/s13567-015-0184-1
Aurora Romero Tejeda and Roberta Aiello contributed equally to this work.
The electronic version of this article is the complete one and can be found online at: http://www.veterinaryresearch.org/content/46/1/51
[TABLE="cellpadding: 0, cellspacing: 0"]
[TR]
[TD]Received:[/TD]
[TD]13 January 2015[/TD]
[/TR]
[TR]
[TD]Accepted:[/TD]
[TD]13 April 2015[/TD]
[/TR]
[TR]
[TD]Published:[/TD]
[TD]13 May 2015[/TD]
[/TR]
[/TABLE]
? 2015 Romero Tejeda et al; licensee BioMed Central.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
[h=3]Abstract[/h] The study of influenza type A (IA) infections in wild mammals populations is a critical gap in our knowledge of how IA viruses evolve in novel hosts that could be in close contact with avian reservoir species and other wild animals. The aim of this study was to evaluate the susceptibility to infection, the nasal shedding and the transmissibility of the H7N1 and H5N1 highly pathogenic avian influenza (HPAI) viruses in the bank vole (Myodes glareolus), a wild rodent common throughout Europe and Asia. Two out of 24 H5N1-infected voles displayed evident respiratory distress, while H7N1-infected voles remained asymptomatic. Viable virus was isolated from nasal washes collected from animals infected with both HPAI viruses, and extra-pulmonary infection was confirmed in both experimental groups. Histopathological lesions were evident in the respiratory tract of infected animals, although immunohistochemistry positivity was only detected in lungs and trachea of two H7N1-infected voles. Both HPAI viruses were transmitted by direct contact, and seroconversion was confirmed in 50% and 12.5% of the asymptomatic sentinels in the H7N1 and H5N1 groups, respectively. Interestingly, viable virus was isolated from lungs and nasal washes collected from contact sentinels of both groups. The present study demonstrated that two non-rodent adapted HPAI viruses caused asymptomatic infection in bank voles, which shed high amounts of the viruses and were able to infect contact voles. Further investigations are needed to determine whether bank voles could be involved as silent hosts in the transmission of HPAI viruses to other mammals and domestic poultry.
open access
http://www.veterinaryresearch.org/content/46/1/51