tetano
Editor, Senior Moderator
Vet Res
. 2020 Oct 17;51(1):132.
doi: 10.1186/s13567-020-00856-z.
Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection
Jing Yang[SUP] 1 [/SUP], Xinmei Huang[SUP] 1 2 [/SUP], Yuzhuo Liu[SUP] 1 [/SUP], Dongmin Zhao[SUP] 1 2 [/SUP], Kaikai Han[SUP] 1 2 [/SUP], Lijiao Zhang[SUP] 1 [/SUP], Yin Li[SUP] 1 2 [/SUP], Qingtao Liu[SUP] 3 [/SUP]
Affiliations
Abstract
MicroRNA (miRNA) plays a key role in virus-host interactions. Here, we employed deep sequencing technology to determine cellular miRNA expression profiles in chicken dendritic cells infected with H9N2 avian influenza virus (AIV). A total of 66 known and 36 novel miRNAs were differently expressed upon H9N2 infection, including 72 up-regulated and 30 down-regulated miRNAs. Functional analysis showed that the predicted targets of these miRNAs were significantly enriched in several pathways including endocytosis, notch, lysosome, p53, RIG-I-like and NOD-like receptor signaling pathways. These data provide valuable information for further investigating the roles of miRNA in AIV pathogenesis and host defense response.
Keywords: H9N2 avian influenza virus; chicken dendritic cell; host defense response; microRNA; pathogenesis.
. 2020 Oct 17;51(1):132.
doi: 10.1186/s13567-020-00856-z.
Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection
Jing Yang[SUP] 1 [/SUP], Xinmei Huang[SUP] 1 2 [/SUP], Yuzhuo Liu[SUP] 1 [/SUP], Dongmin Zhao[SUP] 1 2 [/SUP], Kaikai Han[SUP] 1 2 [/SUP], Lijiao Zhang[SUP] 1 [/SUP], Yin Li[SUP] 1 2 [/SUP], Qingtao Liu[SUP] 3 [/SUP]
Affiliations
- PMID: 33069243
- DOI: 10.1186/s13567-020-00856-z
Abstract
MicroRNA (miRNA) plays a key role in virus-host interactions. Here, we employed deep sequencing technology to determine cellular miRNA expression profiles in chicken dendritic cells infected with H9N2 avian influenza virus (AIV). A total of 66 known and 36 novel miRNAs were differently expressed upon H9N2 infection, including 72 up-regulated and 30 down-regulated miRNAs. Functional analysis showed that the predicted targets of these miRNAs were significantly enriched in several pathways including endocytosis, notch, lysosome, p53, RIG-I-like and NOD-like receptor signaling pathways. These data provide valuable information for further investigating the roles of miRNA in AIV pathogenesis and host defense response.
Keywords: H9N2 avian influenza virus; chicken dendritic cell; host defense response; microRNA; pathogenesis.