Mary Wilson
Well-known member
February 8, 2023
https://doi.org/10.1016/j.chom.2022.12.013
Kaushal Baid1 and Arinjay Banerjee1,2,3,4,5,*
Cellular entry receptors for bat MERS-CoV-like viruses NeoCoV and PDF-2180 were unknown, leaving their zoonotic potential ambiguous. A recent study by Xiong et al. published in Nature identified bat ACE2 as the cellular entry receptor for both viruses, highlighting the ability of coronaviruses to utilize a range of entry receptors.
In 2012, a novel coronavirus (CoV) was isolated from a 60-year old man with acute pneumonia and subsequent renal failure who later died.1 The virus was later named Middle East respiratory syndrome coronavirus (MERS-CoV). Subsequently, MERS-CoV-like viruses were identified in vesper bats, establishing some members of the Vespertilionidae family as the likely ancestral hosts of MERS-CoV.2,3 Two such MERS-CoV-like viruses, NeoCoV and PDF-2180, were detected in Neoro- micia capensis (reclassified as Laephotis capensis) and Pipistrellus hesperidusbats, respectively.2,4–6 NeoCoV is the closest known relative of MERS-CoV and is 85% similar to MERS-CoV at the whole-genome nucleotide level. Subse- quently, MERS-CoV was detected and isolated from dromedary camels estab- lishing camels as the direct zoonotic source of infection for humans.7,8
Identifying the viral surface protein and its cellular-interacting partner (receptor) is critical to estimate host range and cellular tropism, along with informing the development of therapeutics and vac- cines. In 2013, human and Pipistrellus pipistrellus dipeptidylpeptidase 4 (DPP4) were reported as functional cellular re- ceptors of MERS-CoV.9 The receptors for NeoCoV and PDF-2180 remained un- known, until now. In their recent study, Xiong and colleagues demonstrate that despite the close relationship of NeoCoV and PDF-2180 to MERS-CoV, both vi- ruses use bat angiotensin-converting enzyme 2 (ACE2) as entry receptors, un- like MERS-CoV that uses DPP4.6 ...
https://www.cell.com/action/showPdf?pii=S1931-3128(22)00614-X
https://doi.org/10.1016/j.chom.2022.12.013
Kaushal Baid1 and Arinjay Banerjee1,2,3,4,5,*
Cellular entry receptors for bat MERS-CoV-like viruses NeoCoV and PDF-2180 were unknown, leaving their zoonotic potential ambiguous. A recent study by Xiong et al. published in Nature identified bat ACE2 as the cellular entry receptor for both viruses, highlighting the ability of coronaviruses to utilize a range of entry receptors.
In 2012, a novel coronavirus (CoV) was isolated from a 60-year old man with acute pneumonia and subsequent renal failure who later died.1 The virus was later named Middle East respiratory syndrome coronavirus (MERS-CoV). Subsequently, MERS-CoV-like viruses were identified in vesper bats, establishing some members of the Vespertilionidae family as the likely ancestral hosts of MERS-CoV.2,3 Two such MERS-CoV-like viruses, NeoCoV and PDF-2180, were detected in Neoro- micia capensis (reclassified as Laephotis capensis) and Pipistrellus hesperidusbats, respectively.2,4–6 NeoCoV is the closest known relative of MERS-CoV and is 85% similar to MERS-CoV at the whole-genome nucleotide level. Subse- quently, MERS-CoV was detected and isolated from dromedary camels estab- lishing camels as the direct zoonotic source of infection for humans.7,8
Identifying the viral surface protein and its cellular-interacting partner (receptor) is critical to estimate host range and cellular tropism, along with informing the development of therapeutics and vac- cines. In 2013, human and Pipistrellus pipistrellus dipeptidylpeptidase 4 (DPP4) were reported as functional cellular re- ceptors of MERS-CoV.9 The receptors for NeoCoV and PDF-2180 remained un- known, until now. In their recent study, Xiong and colleagues demonstrate that despite the close relationship of NeoCoV and PDF-2180 to MERS-CoV, both vi- ruses use bat angiotensin-converting enzyme 2 (ACE2) as entry receptors, un- like MERS-CoV that uses DPP4.6 ...
https://www.cell.com/action/showPdf?pii=S1931-3128(22)00614-X