tetano
Editor, Senior Moderator
Curr Opin Immunol. 2013 Aug 13. pii: S0952-7915(13)00113-1. doi: 10.1016/j.coi.2013.07.009. [Epub ahead of print]
Variability in the immune system: of vaccine responses and immune states.
Shen-Orr SS, Furman D.
Source
Rappaport Institute of Medical Research, Faculty of Medicine and Faculty of Biology, Technion-Israel Institute of Technology, Haifa 31096, Israel. Electronic address: shenorr@technion.ac.il.
Abstract
System-wide approaches are now being applied to study vaccine responses, whose mechanisms of action, and failure, are not well understood. These works have repeatedly shown vaccine response to be an orchestrated process involving multiple arms of immunity most noticeable sensing and innate components. Prediction of vaccine responses based on system-wide measures is achievable, but challenges remain for robust population wide predictions based only on pre-vaccination measures, especially in partially efficacious vaccines such as influenza. This is especially true in older adults, who are often less responsive to vaccination and exhibit high level of variation compared to young in many components of immunity. Despite this increase in variation, most of the studies on aging use group averages of immune phenotypes to model immune system behavior. Using systems approaches, it is possible to exploit this variation to form distinguishable clusters of phenotypes within and across individuals to discover underlying immune states.
Copyright ? 2013 Elsevier Ltd. All rights reserved.
PMID:
23953808
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23953808
Variability in the immune system: of vaccine responses and immune states.
Shen-Orr SS, Furman D.
Source
Rappaport Institute of Medical Research, Faculty of Medicine and Faculty of Biology, Technion-Israel Institute of Technology, Haifa 31096, Israel. Electronic address: shenorr@technion.ac.il.
Abstract
System-wide approaches are now being applied to study vaccine responses, whose mechanisms of action, and failure, are not well understood. These works have repeatedly shown vaccine response to be an orchestrated process involving multiple arms of immunity most noticeable sensing and innate components. Prediction of vaccine responses based on system-wide measures is achievable, but challenges remain for robust population wide predictions based only on pre-vaccination measures, especially in partially efficacious vaccines such as influenza. This is especially true in older adults, who are often less responsive to vaccination and exhibit high level of variation compared to young in many components of immunity. Despite this increase in variation, most of the studies on aging use group averages of immune phenotypes to model immune system behavior. Using systems approaches, it is possible to exploit this variation to form distinguishable clusters of phenotypes within and across individuals to discover underlying immune states.
Copyright ? 2013 Elsevier Ltd. All rights reserved.
PMID:
23953808
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23953808