tetano
Editor, Senior Moderator
Vaccines (Basel)
. 2021 Mar 13;9(3):257.
doi: 10.3390/vaccines9030257.
Strategies Targeting Hemagglutinin as a Universal Influenza Vaccine
Brianna L Bullard[SUP] 1 [/SUP], Eric A Weaver[SUP] 1 [/SUP]
Affiliations
Abstract
Influenza virus has significant viral diversity, both through antigenic drift and shift, which makes development of a vaccine challenging. Current influenza vaccines are updated yearly to include strains predicted to circulate in the upcoming influenza season, however this can lead to a mismatch which reduces vaccine efficacy. Several strategies targeting the most abundant and immunogenic surface protein of influenza, the hemagglutinin (HA) protein, have been explored. These strategies include stalk-directed, consensus-based, and computationally derived HA immunogens. In this review, we explore vaccine strategies which utilize novel antigen design of the HA protein to improve cross-reactive immunity for development of a universal influenza vaccine.
Keywords: COBRA; ancestral; centralized; chimeric; consensus; epigraph; headless; mosaic; stalk; universal vaccine.
. 2021 Mar 13;9(3):257.
doi: 10.3390/vaccines9030257.
Strategies Targeting Hemagglutinin as a Universal Influenza Vaccine
Brianna L Bullard[SUP] 1 [/SUP], Eric A Weaver[SUP] 1 [/SUP]
Affiliations
- PMID: 33805749
- DOI: 10.3390/vaccines9030257
Abstract
Influenza virus has significant viral diversity, both through antigenic drift and shift, which makes development of a vaccine challenging. Current influenza vaccines are updated yearly to include strains predicted to circulate in the upcoming influenza season, however this can lead to a mismatch which reduces vaccine efficacy. Several strategies targeting the most abundant and immunogenic surface protein of influenza, the hemagglutinin (HA) protein, have been explored. These strategies include stalk-directed, consensus-based, and computationally derived HA immunogens. In this review, we explore vaccine strategies which utilize novel antigen design of the HA protein to improve cross-reactive immunity for development of a universal influenza vaccine.
Keywords: COBRA; ancestral; centralized; chimeric; consensus; epigraph; headless; mosaic; stalk; universal vaccine.