tetano
Editor, Senior Moderator
Vaccines (Basel)
. 2021 Oct 21;9(11):1223.
doi: 10.3390/vaccines9111223.
Pfizer-BioNTech and Sinopharm: A Comparative Study on Post-Vaccination Antibody Titers
Rami Alqassieh[SUP] 1 [/SUP], Aiman Suleiman[SUP] 2 [/SUP], Sami Abu-Halaweh[SUP] 3 [/SUP], Abeer Santarisi[SUP] 4 [/SUP], Omar Shatnawi[SUP] 5 [/SUP], Lara Shdaifat[SUP] 6 [/SUP], Amjed Tarifi[SUP] 1 [/SUP], Mohammad Al-Tamimi[SUP] 7 [/SUP], Abdel-Ellah Al-Shudifat[SUP] 7 [/SUP], Heba Alsmadi[SUP] 3 [/SUP], Ahmed Al Sharqawi[SUP] 3 [/SUP], Hadeel Alnawaiseh[SUP] 3 [/SUP], Yara Anasweh[SUP] 3 [/SUP], Farah Abo Domaidah[SUP] 3 [/SUP], Haneen Abu Jaber[SUP] 3 [/SUP], Mohammad Rashid Al-Zarir[SUP] 3 [/SUP], Isam Bsisu[SUP] 3 [/SUP]
Affiliations
Abstract
COVID-19 (coronavirus disease 2019) vaccines induce immunity through different mechanisms. The aim of this study is to compare the titers of specific antibodies in subjects vaccinated with either the Pfizer-BioNTech COVID-19 vaccine or the Sinopharm vaccine. This prospective observational cohort included Jordanian adults vaccinated with two doses, 21 days apart, of either of the two aforementioned vaccines. Titers were collected 6 weeks after the administration of the second dose. Overall, 288 participants were included, of which 141 were administered the Pfizer-BioNTech vaccine, while 147 were administered the Sinopharm vaccine. Remarkably, 140 (99.3%) of the Pfizer-BioNTech vaccine recipients had positive IgG titers, while 126 (85.7%) of Sinopharm recipients had positive IgG (p < 0.001). The mean titer for IgG among Pfizer-BioNTech recipients was 515.5 ± 1143.5 BAU/mL, compared to 170.0 ± 230.0 BAU/mL among Sinopharm subjects (p < 0.001). Multivariable regression analysis showed that the Pfizer-BioNTech vaccine positively correlated with positive IgG titers (OR: 25.25; 95% CI: 3.25-196.15; p = 0.002), compared with a negative effect of cardiovascular diseases (OR: 0.33; 95% CI: 0.11-0.99; p = 0.48) on IgG titers. In conclusion, fully vaccinated recipients of the Pfizer-BioNTech vaccine had superior quantitative efficiency compared to Sinopharm recipients. A booster dose is supported for Sinopharm recipients, or those with chronic immunosuppressive diseases.
Keywords: COVID-19; Pfizer-BioNTech; Sinopharm; antibody; titers; vaccine.
. 2021 Oct 21;9(11):1223.
doi: 10.3390/vaccines9111223.
Pfizer-BioNTech and Sinopharm: A Comparative Study on Post-Vaccination Antibody Titers
Rami Alqassieh[SUP] 1 [/SUP], Aiman Suleiman[SUP] 2 [/SUP], Sami Abu-Halaweh[SUP] 3 [/SUP], Abeer Santarisi[SUP] 4 [/SUP], Omar Shatnawi[SUP] 5 [/SUP], Lara Shdaifat[SUP] 6 [/SUP], Amjed Tarifi[SUP] 1 [/SUP], Mohammad Al-Tamimi[SUP] 7 [/SUP], Abdel-Ellah Al-Shudifat[SUP] 7 [/SUP], Heba Alsmadi[SUP] 3 [/SUP], Ahmed Al Sharqawi[SUP] 3 [/SUP], Hadeel Alnawaiseh[SUP] 3 [/SUP], Yara Anasweh[SUP] 3 [/SUP], Farah Abo Domaidah[SUP] 3 [/SUP], Haneen Abu Jaber[SUP] 3 [/SUP], Mohammad Rashid Al-Zarir[SUP] 3 [/SUP], Isam Bsisu[SUP] 3 [/SUP]
Affiliations
- PMID: 34835153
- DOI: 10.3390/vaccines9111223
Abstract
COVID-19 (coronavirus disease 2019) vaccines induce immunity through different mechanisms. The aim of this study is to compare the titers of specific antibodies in subjects vaccinated with either the Pfizer-BioNTech COVID-19 vaccine or the Sinopharm vaccine. This prospective observational cohort included Jordanian adults vaccinated with two doses, 21 days apart, of either of the two aforementioned vaccines. Titers were collected 6 weeks after the administration of the second dose. Overall, 288 participants were included, of which 141 were administered the Pfizer-BioNTech vaccine, while 147 were administered the Sinopharm vaccine. Remarkably, 140 (99.3%) of the Pfizer-BioNTech vaccine recipients had positive IgG titers, while 126 (85.7%) of Sinopharm recipients had positive IgG (p < 0.001). The mean titer for IgG among Pfizer-BioNTech recipients was 515.5 ± 1143.5 BAU/mL, compared to 170.0 ± 230.0 BAU/mL among Sinopharm subjects (p < 0.001). Multivariable regression analysis showed that the Pfizer-BioNTech vaccine positively correlated with positive IgG titers (OR: 25.25; 95% CI: 3.25-196.15; p = 0.002), compared with a negative effect of cardiovascular diseases (OR: 0.33; 95% CI: 0.11-0.99; p = 0.48) on IgG titers. In conclusion, fully vaccinated recipients of the Pfizer-BioNTech vaccine had superior quantitative efficiency compared to Sinopharm recipients. A booster dose is supported for Sinopharm recipients, or those with chronic immunosuppressive diseases.
Keywords: COVID-19; Pfizer-BioNTech; Sinopharm; antibody; titers; vaccine.