tetano
Editor, Senior Moderator
Vaccines (Basel)
. 2022 Feb 6;10(2):246.
doi: 10.3390/vaccines10020246.
Effectiveness and Safety of COVID-19 Vaccine among Pregnant Women in Real-World Studies: A Systematic Review and Meta-Analysis
Yirui Ma[SUP] 1 [/SUP], Jie Deng[SUP] 1 [/SUP], Qiao Liu[SUP] 1 [/SUP], Min Du[SUP] 1 [/SUP], Min Liu[SUP] 1 [/SUP], Jue Liu[SUP] 1 2 [/SUP]
Affiliations
Abstract
We aimed to assess the effectiveness and safety of coronavirus disease 2019 (COVID-19) vaccines for pregnant women in real-world studies. We searched for observational studies about the effectiveness and safety of COVID-19 vaccines among vaccinated pregnant women from inception to 6 November 2021. A total of 6 studies were included. We found that vaccination prevented pregnant women from SARS-CoV-2 infection (OR = 0.50, 95% CI, 0.35-0.79) and COVID-19-related hospitalization (OR = 0.50, 95% CI, 0.31-0.82). Messenger-RNA vaccines could reduce the risk of infection in pregnant women (OR = 0.13, 95% CI, 0.03-0.57). No adverse events of COVID-19 vaccination were found on pregnant, fetal, or neonatal outcomes. Our analysis confirmed the effectiveness and safety of COVID-19 vaccines for pregnant women. Policy makers should formulate targeted strategies to improve vaccine coverage in pregnant women.
Keywords: COVID-19 vaccine; effectiveness; meta-analysis; pregnancy; safety; systematic review.
. 2022 Feb 6;10(2):246.
doi: 10.3390/vaccines10020246.
Effectiveness and Safety of COVID-19 Vaccine among Pregnant Women in Real-World Studies: A Systematic Review and Meta-Analysis
Yirui Ma[SUP] 1 [/SUP], Jie Deng[SUP] 1 [/SUP], Qiao Liu[SUP] 1 [/SUP], Min Du[SUP] 1 [/SUP], Min Liu[SUP] 1 [/SUP], Jue Liu[SUP] 1 2 [/SUP]
Affiliations
- PMID: 35214704
- DOI: 10.3390/vaccines10020246
Abstract
We aimed to assess the effectiveness and safety of coronavirus disease 2019 (COVID-19) vaccines for pregnant women in real-world studies. We searched for observational studies about the effectiveness and safety of COVID-19 vaccines among vaccinated pregnant women from inception to 6 November 2021. A total of 6 studies were included. We found that vaccination prevented pregnant women from SARS-CoV-2 infection (OR = 0.50, 95% CI, 0.35-0.79) and COVID-19-related hospitalization (OR = 0.50, 95% CI, 0.31-0.82). Messenger-RNA vaccines could reduce the risk of infection in pregnant women (OR = 0.13, 95% CI, 0.03-0.57). No adverse events of COVID-19 vaccination were found on pregnant, fetal, or neonatal outcomes. Our analysis confirmed the effectiveness and safety of COVID-19 vaccines for pregnant women. Policy makers should formulate targeted strategies to improve vaccine coverage in pregnant women.
Keywords: COVID-19 vaccine; effectiveness; meta-analysis; pregnancy; safety; systematic review.