tetano
Editor, Senior Moderator
Vaccines (Basel)
. 2022 Jul 26;10(8):1181.
doi: 10.3390/vaccines10081181.
Clinical and Virological Features of Patients Hospitalized with Different Types of COVID-19 Vaccination in Mexico City
Alejandra Hernández-Terán[SUP] 1 [/SUP], Pamela Garcíadiego-Fossas[SUP] 2 [/SUP], Marco Villanueva-Reza[SUP] 2 [/SUP], Celia Boukadida[SUP] 3 [/SUP], Blanca Taboada[SUP] 4 [/SUP], Eduardo Porras[SUP] 2 [/SUP], Victor Ahumada-Topete[SUP] 2 [/SUP], Kathia Elizabeth Tapia-Diaz[SUP] 3 [/SUP], Margarita Matías-Florentino[SUP] 3 [/SUP], Marissa Pérez-García[SUP] 3 [/SUP], Santiago Ávila-Ríos[SUP] 3 [/SUP], Fidencio Mejía-Nepomuceno[SUP] 1 [/SUP], Ricardo Serna-Muñoz[SUP] 1 [/SUP], Fortunato Juárez-Hernández[SUP] 5 [/SUP], María Eugenia Jiménez-Corona[SUP] 6 [/SUP], Eduardo Becerril-Vargas[SUP] 7 [/SUP], Omar Barreto[SUP] 8 [/SUP], Jose Arturo Martínez-Orozco[SUP] 7 [/SUP], Rogelio Pérez-Padilla[SUP] 1 [/SUP], Carlos F Arias[SUP] 4 [/SUP], Joel Armando Vázquez-Pérez[SUP] 1 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) vaccines effectively protect against severe disease and death. However, the impact of the vaccine used, viral variants, and host factors on disease severity remain poorly understood. This work aimed to compare COVID-19 clinical presentations and outcomes in vaccinated and unvaccinated patients in Mexico City. From March to September 2021, clinical, demographic characteristics, and viral variants were obtained from 1014 individuals with a documented SARS-CoV-2 infection. We compared unvaccinated, partially vaccinated, and fully vaccinated patients, stratifying by age groups. We also fitted multivariate statistical models to evaluate the impact of vaccination status, SARS-CoV-2 lineages, vaccine types, and clinical parameters. Most hospitalized patients were unvaccinated. In patients over 61 years old, mortality was significantly higher in unvaccinated compared to fully vaccinated individuals. In patients aged 31 to 60 years, vaccinated patients were more likely to be outpatients (46%) than unvaccinated individuals (6.1%). We found immune disease and age above 61 years old to be risk factors, while full vaccination was found to be the most protective factor against in-hospital death. This study suggests that vaccination is essential to reduce mortality in a comorbid population such as that of Mexico.
Keywords: COVID-19; COVID-19 severity; SARS-CoV-2 lineages; comorbidities in COVID-19; vaccination schemes.
. 2022 Jul 26;10(8):1181.
doi: 10.3390/vaccines10081181.
Clinical and Virological Features of Patients Hospitalized with Different Types of COVID-19 Vaccination in Mexico City
Alejandra Hernández-Terán[SUP] 1 [/SUP], Pamela Garcíadiego-Fossas[SUP] 2 [/SUP], Marco Villanueva-Reza[SUP] 2 [/SUP], Celia Boukadida[SUP] 3 [/SUP], Blanca Taboada[SUP] 4 [/SUP], Eduardo Porras[SUP] 2 [/SUP], Victor Ahumada-Topete[SUP] 2 [/SUP], Kathia Elizabeth Tapia-Diaz[SUP] 3 [/SUP], Margarita Matías-Florentino[SUP] 3 [/SUP], Marissa Pérez-García[SUP] 3 [/SUP], Santiago Ávila-Ríos[SUP] 3 [/SUP], Fidencio Mejía-Nepomuceno[SUP] 1 [/SUP], Ricardo Serna-Muñoz[SUP] 1 [/SUP], Fortunato Juárez-Hernández[SUP] 5 [/SUP], María Eugenia Jiménez-Corona[SUP] 6 [/SUP], Eduardo Becerril-Vargas[SUP] 7 [/SUP], Omar Barreto[SUP] 8 [/SUP], Jose Arturo Martínez-Orozco[SUP] 7 [/SUP], Rogelio Pérez-Padilla[SUP] 1 [/SUP], Carlos F Arias[SUP] 4 [/SUP], Joel Armando Vázquez-Pérez[SUP] 1 [/SUP]
Affiliations
- PMID: 35893830
- DOI: 10.3390/vaccines10081181
Abstract
Coronavirus disease 2019 (COVID-19) vaccines effectively protect against severe disease and death. However, the impact of the vaccine used, viral variants, and host factors on disease severity remain poorly understood. This work aimed to compare COVID-19 clinical presentations and outcomes in vaccinated and unvaccinated patients in Mexico City. From March to September 2021, clinical, demographic characteristics, and viral variants were obtained from 1014 individuals with a documented SARS-CoV-2 infection. We compared unvaccinated, partially vaccinated, and fully vaccinated patients, stratifying by age groups. We also fitted multivariate statistical models to evaluate the impact of vaccination status, SARS-CoV-2 lineages, vaccine types, and clinical parameters. Most hospitalized patients were unvaccinated. In patients over 61 years old, mortality was significantly higher in unvaccinated compared to fully vaccinated individuals. In patients aged 31 to 60 years, vaccinated patients were more likely to be outpatients (46%) than unvaccinated individuals (6.1%). We found immune disease and age above 61 years old to be risk factors, while full vaccination was found to be the most protective factor against in-hospital death. This study suggests that vaccination is essential to reduce mortality in a comorbid population such as that of Mexico.
Keywords: COVID-19; COVID-19 severity; SARS-CoV-2 lineages; comorbidities in COVID-19; vaccination schemes.