tetano
Editor, Senior Moderator
Vaccines (Basel)
. 2022 Oct 1;10(10):1653.
doi: 10.3390/vaccines10101653.
A Vaccine with Multiple Receptor-Binding Domain Subunit Mutations Induces Broad-Spectrum Immune Response against SARS-CoV-2 Variants of Concern
Xu-Chen Hou[SUP] 1 [/SUP], Hui-Fang Xu[SUP] 1 [/SUP], Yang Liu[SUP] 2 [/SUP], Peng Sun[SUP] 1 [/SUP], Lin-Wei Ding[SUP] 1 [/SUP], Jun-Jie Yue[SUP] 1 [/SUP], Tian-Tian Wang[SUP] 1 [/SUP], Xin Gong[SUP] 1 [/SUP], Jun Wu[SUP] 1 [/SUP], Bo Liu[SUP] 1 [/SUP]
Affiliations
Abstract
With the emergence of more variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the immune evasion of these variants from existing vaccines, the development of broad-spectrum vaccines is urgently needed. In this study, we designed a novel SARS-CoV-2 receptor-binding domain (RBD) subunit (RBD5m) by integrating five important mutations from SARS-CoV-2 variants of concern (VOCs). The neutralization activities of antibodies induced by the RBD5m candidate vaccine are more balanced and effective for neutralizing different SARS-CoV-2 VOCs in comparison with those induced by the SARS-CoV-2 prototype strain RBD. Our results suggest that the RBD5m vaccine is a good broad-spectrum vaccine candidate able to prevent disease from several different SARS-CoV-2 VOCs.
Keywords: RBD; SARS-CoV-2; VOCs; subunit vaccine; yeast.
. 2022 Oct 1;10(10):1653.
doi: 10.3390/vaccines10101653.
A Vaccine with Multiple Receptor-Binding Domain Subunit Mutations Induces Broad-Spectrum Immune Response against SARS-CoV-2 Variants of Concern
Xu-Chen Hou[SUP] 1 [/SUP], Hui-Fang Xu[SUP] 1 [/SUP], Yang Liu[SUP] 2 [/SUP], Peng Sun[SUP] 1 [/SUP], Lin-Wei Ding[SUP] 1 [/SUP], Jun-Jie Yue[SUP] 1 [/SUP], Tian-Tian Wang[SUP] 1 [/SUP], Xin Gong[SUP] 1 [/SUP], Jun Wu[SUP] 1 [/SUP], Bo Liu[SUP] 1 [/SUP]
Affiliations
- PMID: 36298518
- DOI: 10.3390/vaccines10101653
Abstract
With the emergence of more variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the immune evasion of these variants from existing vaccines, the development of broad-spectrum vaccines is urgently needed. In this study, we designed a novel SARS-CoV-2 receptor-binding domain (RBD) subunit (RBD5m) by integrating five important mutations from SARS-CoV-2 variants of concern (VOCs). The neutralization activities of antibodies induced by the RBD5m candidate vaccine are more balanced and effective for neutralizing different SARS-CoV-2 VOCs in comparison with those induced by the SARS-CoV-2 prototype strain RBD. Our results suggest that the RBD5m vaccine is a good broad-spectrum vaccine candidate able to prevent disease from several different SARS-CoV-2 VOCs.
Keywords: RBD; SARS-CoV-2; VOCs; subunit vaccine; yeast.