tetano
Editor, Senior Moderator
Eur J Epidemiol. 2019 Dec 19. doi: 10.1007/s10654-019-00596-1. [Epub ahead of print] [h=1]Vaccines and the risk of Guillain-Barr? syndrome.[/h]
Chen Y[SUP]1[/SUP], Zhang J[SUP]2[/SUP], Chu X[SUP]3[/SUP], Xu Y[SUP]4[/SUP], Ma F[SUP]2[/SUP].
[h=3]Author information[/h] 1 Integrated Operations Management Office, Jiangsu Provincial Center for Disease Control and Prevention, 172 Street Jiangsu, Nanjing, 210009, Jiangsu Province, People's Republic of China. chenyong12345678@163.com. 2 Department of Expanded Program on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, People's Republic of China. 3 Department of Neurology, Jiangsu Provincial People's Hospital, Nanjing, People's Republic of China. 4 Department of Neurology, Nanjing Brain Hospital, Nanjing, People's Republic of China.
[h=3]Abstract[/h] The role of vaccination in the development of Guillain-Barr? syndrome (GBS) is controversial, although cases of GBS have been reported following a wide range of vaccines. A nested case-control study was conducted between January 2011 and December 2015 in three Chinese cities. Four controls were matched to a case by gender, age, address and index date. An independent expert committee validated the diagnoses of cases and controls according to the Brighton Collaboration GBS case definition. Data on vaccinations were obtained from computerized vaccination records. Causal relations were assessed by conditional logistic regression. 1056 cases of GBS and 4312 controls were included in the analyses. Among paediatric and adult population, adjusted ORs for GBS occurrence within 180 days following vaccination were 0.94 (95% CI 0.54-1.62) and 1.09 (95% CI 0.88-1.32), respectively. No increased risk of GBS was detected for vaccination against hepatitis B, influenza, hepatitis A, varicella, rabies, polio(live), diphtheria, pertuss(acellular), tetanusis, measles, mumps, rubella, Japanese Encephalitis, and meningitis vaccines. Adjusted ORs for the recurrence of GBS after vaccination among paediatric and adult population were 0.85 (95% CI 0.07-9.50) and 1.18 (95% CI 0.49-2.65), respectively. In this large retrospective study, we did not find evidence of an increased risk of GBS and its recurrence among either paediatric (≤ 18 years) or adult (> 18 years) individuals within the 180 days following vaccinations of any kind, including influenza vaccination.
[h=4]KEYWORDS:[/h] Case–control; Guillain-Barr? syndrome; Vaccines
PMID: 31858323 DOI: 10.1007/s10654-019-00596-1
Chen Y[SUP]1[/SUP], Zhang J[SUP]2[/SUP], Chu X[SUP]3[/SUP], Xu Y[SUP]4[/SUP], Ma F[SUP]2[/SUP].
[h=3]Author information[/h] 1 Integrated Operations Management Office, Jiangsu Provincial Center for Disease Control and Prevention, 172 Street Jiangsu, Nanjing, 210009, Jiangsu Province, People's Republic of China. chenyong12345678@163.com. 2 Department of Expanded Program on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, People's Republic of China. 3 Department of Neurology, Jiangsu Provincial People's Hospital, Nanjing, People's Republic of China. 4 Department of Neurology, Nanjing Brain Hospital, Nanjing, People's Republic of China.
[h=3]Abstract[/h] The role of vaccination in the development of Guillain-Barr? syndrome (GBS) is controversial, although cases of GBS have been reported following a wide range of vaccines. A nested case-control study was conducted between January 2011 and December 2015 in three Chinese cities. Four controls were matched to a case by gender, age, address and index date. An independent expert committee validated the diagnoses of cases and controls according to the Brighton Collaboration GBS case definition. Data on vaccinations were obtained from computerized vaccination records. Causal relations were assessed by conditional logistic regression. 1056 cases of GBS and 4312 controls were included in the analyses. Among paediatric and adult population, adjusted ORs for GBS occurrence within 180 days following vaccination were 0.94 (95% CI 0.54-1.62) and 1.09 (95% CI 0.88-1.32), respectively. No increased risk of GBS was detected for vaccination against hepatitis B, influenza, hepatitis A, varicella, rabies, polio(live), diphtheria, pertuss(acellular), tetanusis, measles, mumps, rubella, Japanese Encephalitis, and meningitis vaccines. Adjusted ORs for the recurrence of GBS after vaccination among paediatric and adult population were 0.85 (95% CI 0.07-9.50) and 1.18 (95% CI 0.49-2.65), respectively. In this large retrospective study, we did not find evidence of an increased risk of GBS and its recurrence among either paediatric (≤ 18 years) or adult (> 18 years) individuals within the 180 days following vaccinations of any kind, including influenza vaccination.
[h=4]KEYWORDS:[/h] Case–control; Guillain-Barr? syndrome; Vaccines
PMID: 31858323 DOI: 10.1007/s10654-019-00596-1