Giuseppe
Emeritus
ScienceDirect - Vaccine, Volume 26 - Immunogenetics of seasonal influenza vaccine response
Abstract
Seasonal influenza causes significant morbidity, mortality, and economic costs.
Vaccines against influenza, though both safe and effective, are imperfect.
Notably, these vaccines result in significant immune response variability across the population.
The mechanism for this variability, in part, appears to lie in the polymorphisms of key immune response genes.
Despite the importance of this variability, little in the way of genetic polymorphisms and its association with vaccine immune response to viral vaccines has been performed.
Herein, we review and synthesize what is known about the immune response pathway and influenza viral immunity and then present original data from our laboratory on the immunogenetic relationships between HLA, cytokine and cytokine receptor gene polymorphisms and the variations in humoral immune response to inactivated seasonal influenza vaccine.
Finally, we propose that a better understanding of vaccine immunogenetics offers insight towards the development of better influenza vaccines.
<cite cite="http://www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%235188%232008%23999739999.8995%23697888%23FLA%23&_cdi=5188&_pubType=J&_auth=y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=9aa2a4077daed1b96fb5cdd42d8aaf3c">ScienceDirect - Vaccine, Volume 26, Supplement 4, Pages D1-D74 (12 September 2008)</cite>Seasonal influenza causes significant morbidity, mortality, and economic costs.
Vaccines against influenza, though both safe and effective, are imperfect.
Notably, these vaccines result in significant immune response variability across the population.
The mechanism for this variability, in part, appears to lie in the polymorphisms of key immune response genes.
Despite the importance of this variability, little in the way of genetic polymorphisms and its association with vaccine immune response to viral vaccines has been performed.
Herein, we review and synthesize what is known about the immune response pathway and influenza viral immunity and then present original data from our laboratory on the immunogenetic relationships between HLA, cytokine and cytokine receptor gene polymorphisms and the variations in humoral immune response to inactivated seasonal influenza vaccine.
Finally, we propose that a better understanding of vaccine immunogenetics offers insight towards the development of better influenza vaccines.