tetano
Editor, Senior Moderator
Vaccine
. 2022 Aug 25;S0264-410X(22)01046-5.
doi: 10.1016/j.vaccine.2022.08.056. Online ahead of print.
Vasovagal reactions after COVID-19 vaccination in Japan
Mai Okuyama[SUP] 1 [/SUP], Saeko Morino[SUP] 1 [/SUP], Kaori Tanaka[SUP] 1 [/SUP], Haruna Nakamura-Miwa[SUP] 1 [/SUP], Sayaka Takanashi[SUP] 1 [/SUP], Satoru Arai[SUP] 1 [/SUP], Masaki Ochiai[SUP] 2 [/SUP], Koji Ishii[SUP] 2 [/SUP], Motoi Suzuki[SUP] 1 [/SUP], Akira Oka[SUP] 3 [/SUP], Tomohiro Morio[SUP] 4 [/SUP], Keiko Tanaka-Taya[SUP] 5 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) vaccine administration started in February 2021 in Japan. As of December 2021, approximately 75% of the population aged ≥12 years had received two doses of vaccine. We conducted a study to investigate vasovagal reactions (VVR) after COVID-19 vaccination using data on adverse events following immunization. The crude reporting rate of VVR (cases/1,000,000 doses) after vaccination was 9.6 in all age groups combined, and was more frequent in the younger age groups: 28.6 and 37.2 in individuals aged 10-19 years and 20-29 years, respectively. In individuals aged 10-29 years, the rate was similar in males and females (33.0 and 34.2, respectively, p = 0.53); but was higher after dose 1 than after dose 2 (57.4 and 8.8, respectively, p < 0.001). Based on these results, caution needs to be exercised when vaccinating adolescents and young adults, especially with dose 1 of COVID-19 vaccines.
Keywords: Adolescents; Adverse event following immunization; COVID-19 vaccination; Immunization stress-related responses; Vasovagal reaction; Young adults.
. 2022 Aug 25;S0264-410X(22)01046-5.
doi: 10.1016/j.vaccine.2022.08.056. Online ahead of print.
Vasovagal reactions after COVID-19 vaccination in Japan
Mai Okuyama[SUP] 1 [/SUP], Saeko Morino[SUP] 1 [/SUP], Kaori Tanaka[SUP] 1 [/SUP], Haruna Nakamura-Miwa[SUP] 1 [/SUP], Sayaka Takanashi[SUP] 1 [/SUP], Satoru Arai[SUP] 1 [/SUP], Masaki Ochiai[SUP] 2 [/SUP], Koji Ishii[SUP] 2 [/SUP], Motoi Suzuki[SUP] 1 [/SUP], Akira Oka[SUP] 3 [/SUP], Tomohiro Morio[SUP] 4 [/SUP], Keiko Tanaka-Taya[SUP] 5 [/SUP]
Affiliations
- PMID: 36068111
- DOI: 10.1016/j.vaccine.2022.08.056
Abstract
Coronavirus disease 2019 (COVID-19) vaccine administration started in February 2021 in Japan. As of December 2021, approximately 75% of the population aged ≥12 years had received two doses of vaccine. We conducted a study to investigate vasovagal reactions (VVR) after COVID-19 vaccination using data on adverse events following immunization. The crude reporting rate of VVR (cases/1,000,000 doses) after vaccination was 9.6 in all age groups combined, and was more frequent in the younger age groups: 28.6 and 37.2 in individuals aged 10-19 years and 20-29 years, respectively. In individuals aged 10-29 years, the rate was similar in males and females (33.0 and 34.2, respectively, p = 0.53); but was higher after dose 1 than after dose 2 (57.4 and 8.8, respectively, p < 0.001). Based on these results, caution needs to be exercised when vaccinating adolescents and young adults, especially with dose 1 of COVID-19 vaccines.
Keywords: Adolescents; Adverse event following immunization; COVID-19 vaccination; Immunization stress-related responses; Vasovagal reaction; Young adults.