tetano
Editor, Senior Moderator
Curr Opin Immunol. 2013 Jun 10. pii: S0952-7915(13)00095-2. doi: 10.1016/j.coi.2013.05.014. [Epub ahead of print]
Vaccine strategies to enhance immune responses in the aged.
Lefebvre JS, Haynes L.
Source
Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA.
Abstract
The elderly population is more susceptible to infections with higher risks of morbidity and mortality. This is caused by the accumulation of immune defects with aging. The best way to protect people against infections is vaccination. Unfortunately, the same immune defects that render the elderly susceptible to infectious diseases also prevent the development of protective immunity following immunization. A good example of this is the influenza vaccine that only protects between 40 and 60% of the vaccinees over 65 years. In the past decade, tremendous efforts have been put toward improving the influenza vaccine for the elderly. We therefore use this example to present various strategies employed to overcome these age-associated immune defects and hence make vaccines more efficacious for the aged.
Copyright ? 2013. Published by Elsevier Ltd.
PMID:
23764092
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23764092
Vaccine strategies to enhance immune responses in the aged.
Lefebvre JS, Haynes L.
Source
Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA.
Abstract
The elderly population is more susceptible to infections with higher risks of morbidity and mortality. This is caused by the accumulation of immune defects with aging. The best way to protect people against infections is vaccination. Unfortunately, the same immune defects that render the elderly susceptible to infectious diseases also prevent the development of protective immunity following immunization. A good example of this is the influenza vaccine that only protects between 40 and 60% of the vaccinees over 65 years. In the past decade, tremendous efforts have been put toward improving the influenza vaccine for the elderly. We therefore use this example to present various strategies employed to overcome these age-associated immune defects and hence make vaccines more efficacious for the aged.
Copyright ? 2013. Published by Elsevier Ltd.
PMID:
23764092
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23764092