tetano
Editor, Senior Moderator
Vaccine
Available online 22 October 2012
In Press, Uncorrected Proof ? Note to users
Cover image
Short communication
No association between influenza A(H1N1)pdm09 vaccination and narcolepsy in South Korea: An ecological study
Young June Choea, b, Corresponding author contact information, E-mail the corresponding author,
Geun-Ryang Baea, b,
Duk-hyoung Leeb
a Division of Vaccine Preventable Disease Control and National Immunization Program, Republic of Korea
b Center for Disease Prevention, Korea Centers for Disease Control and Prevention, Osong, Republic of Korea
http://dx.doi.org/10.1016/j.vaccine.2012.10.030, How to Cite or Link Using DOI
Abstract
Background
There is concern about a possible association between influenza A(H1N1)pdm09 vaccination and narcolepsy. In this study, we assessed the incidence and incidence rate of narcolepsy in the South Korean population before and after the implementation of an A(H1N1)pdm09 vaccination campaign to see if vaccination led to a change in the occurrence of narcolepsy.
Methods
We conducted an ecological study, comparing incident cases and incidence rates for newly diagnosed narcolepsy case-patients in South Korea, between July 2006 and June 2011. We used data from the Health Insurance Review Agency and Korea Centers for Disease Control and Prevention, which have limited information on case ascertainment. During vaccination campaign period, South Korea used non-adjuvanted and MF59-adjuvanted A(H1N1)pdm09 vaccines.
Results
Generally, incidence rate was highest in prepandemic period. No trend toward increase in the incidence of narcolepsy after pandemic period was found. Observation of incidence by season did not suggest any time pattern for occurrence of narcolepsy.
Conclusion
No increase in cases or incidence rate for narcolepsy during the A(H1N1)pdm09 vaccination campaign was found in South Korea. Our data do not support the use of MF59-adjuvanted or non-adjuvanted A(H1N1)pdm09 vaccine as a trigger for narcolepsy on a population level.
Highlights
► Generally, incidence rate was highest in prepandemic period. ► No trend toward increase in the incidence of narcolepsy after pandemic period was found. ► Observation of incidence by season did not suggest any time pattern for onset of narcolepsy.
http://www.sciencedirect.com/science/article/pii/S0264410X12014764
Available online 22 October 2012
In Press, Uncorrected Proof ? Note to users
Cover image
Short communication
No association between influenza A(H1N1)pdm09 vaccination and narcolepsy in South Korea: An ecological study
Young June Choea, b, Corresponding author contact information, E-mail the corresponding author,
Geun-Ryang Baea, b,
Duk-hyoung Leeb
a Division of Vaccine Preventable Disease Control and National Immunization Program, Republic of Korea
b Center for Disease Prevention, Korea Centers for Disease Control and Prevention, Osong, Republic of Korea
http://dx.doi.org/10.1016/j.vaccine.2012.10.030, How to Cite or Link Using DOI
Abstract
Background
There is concern about a possible association between influenza A(H1N1)pdm09 vaccination and narcolepsy. In this study, we assessed the incidence and incidence rate of narcolepsy in the South Korean population before and after the implementation of an A(H1N1)pdm09 vaccination campaign to see if vaccination led to a change in the occurrence of narcolepsy.
Methods
We conducted an ecological study, comparing incident cases and incidence rates for newly diagnosed narcolepsy case-patients in South Korea, between July 2006 and June 2011. We used data from the Health Insurance Review Agency and Korea Centers for Disease Control and Prevention, which have limited information on case ascertainment. During vaccination campaign period, South Korea used non-adjuvanted and MF59-adjuvanted A(H1N1)pdm09 vaccines.
Results
Generally, incidence rate was highest in prepandemic period. No trend toward increase in the incidence of narcolepsy after pandemic period was found. Observation of incidence by season did not suggest any time pattern for occurrence of narcolepsy.
Conclusion
No increase in cases or incidence rate for narcolepsy during the A(H1N1)pdm09 vaccination campaign was found in South Korea. Our data do not support the use of MF59-adjuvanted or non-adjuvanted A(H1N1)pdm09 vaccine as a trigger for narcolepsy on a population level.
Highlights
► Generally, incidence rate was highest in prepandemic period. ► No trend toward increase in the incidence of narcolepsy after pandemic period was found. ► Observation of incidence by season did not suggest any time pattern for onset of narcolepsy.
http://www.sciencedirect.com/science/article/pii/S0264410X12014764