Giuseppe
Emeritus
[Source: US National Library of Medicine (LINK). Edited.]
Vaccine. 2010 Apr 27. [Epub ahead of print]
Nasal mucosal administration of chitin microparticles boosts innate immunity against influenza A virus in the local pulmonary tissue.
Baaten BJ, Clarke B, Strong P, Hou S. - The Edward Jenner Institute for Vaccine Research, Compton, RG20 7NN, United Kingdom.
Influenza virus infection remains a major health concern due to morbidity and mortality associated with epidemics and occasional pandemics. The absence of acquired immunity to antigenically distinct, emerging virus strains stresses the need for a generic drug that protects independent of vaccination. Here, we demonstrate that prophylactic administration of chitin microparticles (CMP) via the intranasal route significantly reduced lung viral titres and clinical signs. Pre-treatment boosted the innate immune response to subsequent infection by recruiting innate cells, such as neutrophils, and increasing inflammatory cytokines. Although an increase in virus-specific T cells was observed, the memory phase was diminished. Our data demonstrate that in the absence of prior exposure to influenza virus, CMP reduce clinical signs by boosting innate immunity.
Copyright ? 2010. Published by Elsevier Ltd.
PMID: 20433805 [PubMed - as supplied by publisher]
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Vaccine. 2010 Apr 27. [Epub ahead of print]
Nasal mucosal administration of chitin microparticles boosts innate immunity against influenza A virus in the local pulmonary tissue.
Baaten BJ, Clarke B, Strong P, Hou S. - The Edward Jenner Institute for Vaccine Research, Compton, RG20 7NN, United Kingdom.
Influenza virus infection remains a major health concern due to morbidity and mortality associated with epidemics and occasional pandemics. The absence of acquired immunity to antigenically distinct, emerging virus strains stresses the need for a generic drug that protects independent of vaccination. Here, we demonstrate that prophylactic administration of chitin microparticles (CMP) via the intranasal route significantly reduced lung viral titres and clinical signs. Pre-treatment boosted the innate immune response to subsequent infection by recruiting innate cells, such as neutrophils, and increasing inflammatory cytokines. Although an increase in virus-specific T cells was observed, the memory phase was diminished. Our data demonstrate that in the absence of prior exposure to influenza virus, CMP reduce clinical signs by boosting innate immunity.
Copyright ? 2010. Published by Elsevier Ltd.
PMID: 20433805 [PubMed - as supplied by publisher]
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