tetano
Editor, Senior Moderator
Vaccine
. 2023 Mar 14;S0264-410X(23)00261-X.
doi: 10.1016/j.vaccine.2023.03.014. Online ahead of print.
Mediation and instrumental variable analyses for vaccine-induced antibody titer against influenza B
Jui-Hsiang Lin[SUP] 1 [/SUP], Yi-Ting Huang[SUP] 2 [/SUP], Jih-Chang Yu[SUP] 1 [/SUP], Kin-Wei Arnold Chan[SUP] 3 [/SUP], Yen-Tsung Huang[SUP] 4 [/SUP]
Affiliations
Abstract
Objective: Immune correlate analyses for vaccine trials have been applied to investigate associations of vaccine efficacy and surrogate markers such as vaccine-induced antibodies. However, the role of antibody as a surrogate marker in predicting the outcome can vary by time, and surrogate-outcome confounding may have resulted in bias even in randomized trials. We provide a framework for surrogate marker assessment to address the aforementioned issues.
Study design and setting: We reanalyzed the vaccine randomized trial for influenza B. We conducted a mediation analysis that enables estimation of vaccine efficacy, mediation effects and proportion of mediation on disease probabilities at various follow-up times. We proposed instrumental variable (IV) analyses with randomized vaccination as an IV accounting for potential unmeasured confounding.
Results: The mediation effect of vaccine efficacy by hemagglutination inhibition (HAI) titer was significantly protective at 181 days after vaccination: 63.2% [95% confidence interval, (CI) = (39.9%, 82.0%)], and HAI titer explained 61.1% [95% CI = (36.7%, 96.2%)] of the protective effect of vaccination.
Conclusions: Most of vaccine efficacy is mediated by HAI titer, particularly in children 10 years and older. Our contribution is to provide causal analytics for the role of surrogate marker with weaker assumptions regarding surrogate-disease causation.
Keywords: Influenza vaccine; Instrumental variable analysis; Mediation analysis; Randomized controlled trial; Surrogate endpoint analysis.
. 2023 Mar 14;S0264-410X(23)00261-X.
doi: 10.1016/j.vaccine.2023.03.014. Online ahead of print.
Mediation and instrumental variable analyses for vaccine-induced antibody titer against influenza B
Jui-Hsiang Lin[SUP] 1 [/SUP], Yi-Ting Huang[SUP] 2 [/SUP], Jih-Chang Yu[SUP] 1 [/SUP], Kin-Wei Arnold Chan[SUP] 3 [/SUP], Yen-Tsung Huang[SUP] 4 [/SUP]
Affiliations
- PMID: 36925423
- DOI: 10.1016/j.vaccine.2023.03.014
Abstract
Objective: Immune correlate analyses for vaccine trials have been applied to investigate associations of vaccine efficacy and surrogate markers such as vaccine-induced antibodies. However, the role of antibody as a surrogate marker in predicting the outcome can vary by time, and surrogate-outcome confounding may have resulted in bias even in randomized trials. We provide a framework for surrogate marker assessment to address the aforementioned issues.
Study design and setting: We reanalyzed the vaccine randomized trial for influenza B. We conducted a mediation analysis that enables estimation of vaccine efficacy, mediation effects and proportion of mediation on disease probabilities at various follow-up times. We proposed instrumental variable (IV) analyses with randomized vaccination as an IV accounting for potential unmeasured confounding.
Results: The mediation effect of vaccine efficacy by hemagglutination inhibition (HAI) titer was significantly protective at 181 days after vaccination: 63.2% [95% confidence interval, (CI) = (39.9%, 82.0%)], and HAI titer explained 61.1% [95% CI = (36.7%, 96.2%)] of the protective effect of vaccination.
Conclusions: Most of vaccine efficacy is mediated by HAI titer, particularly in children 10 years and older. Our contribution is to provide causal analytics for the role of surrogate marker with weaker assumptions regarding surrogate-disease causation.
Keywords: Influenza vaccine; Instrumental variable analysis; Mediation analysis; Randomized controlled trial; Surrogate endpoint analysis.