tetano
Editor, Senior Moderator
Vaccine
. 2022 May 20;S0264-410X(22)00614-4.
doi: 10.1016/j.vaccine.2022.05.030. Online ahead of print.
Maternal influenza vaccination and child mortality: Longitudinal, population-based linked cohort study
Damien Foo[SUP] 1 [/SUP], Mohinder Sarna[SUP] 2 [/SUP], Gavin Pereira[SUP] 3 [/SUP], Hannah C Moore[SUP] 2 [/SUP], Annette K Regan[SUP] 4 [/SUP]
Affiliations
Abstract
Influenza vaccination is recommended to protect mothers and their infants from influenza. Few studies have evaluated the association between maternal influenza vaccination and child mortality. We aimed to evaluate the association between in utero exposure to seasonal inactivated influenza vaccine (IIV) and mortality among young children. This longitudinal, population-based cohort study included 191,247 maternal-child pairs in Western Australia between April 2012 and December 2017. Maternal vaccine information was obtained from a state-wide antenatal vaccination database. Mortality was defined as a record of a death registration. We used Cox proportional hazard models, weighted by the inverse-probability of treatment (vaccination), to estimate the hazard ratio of child mortality associated with in utero exposure to seasonal IIV. This study found no association between in utero exposure to seasonal IIV and mortality through age five years.
Keywords: Child health; Maternal vaccination; Mortality; Seasonal influenza vaccine; Vaccine safety.
. 2022 May 20;S0264-410X(22)00614-4.
doi: 10.1016/j.vaccine.2022.05.030. Online ahead of print.
Maternal influenza vaccination and child mortality: Longitudinal, population-based linked cohort study
Damien Foo[SUP] 1 [/SUP], Mohinder Sarna[SUP] 2 [/SUP], Gavin Pereira[SUP] 3 [/SUP], Hannah C Moore[SUP] 2 [/SUP], Annette K Regan[SUP] 4 [/SUP]
Affiliations
- PMID: 35606236
- DOI: 10.1016/j.vaccine.2022.05.030
Abstract
Influenza vaccination is recommended to protect mothers and their infants from influenza. Few studies have evaluated the association between maternal influenza vaccination and child mortality. We aimed to evaluate the association between in utero exposure to seasonal inactivated influenza vaccine (IIV) and mortality among young children. This longitudinal, population-based cohort study included 191,247 maternal-child pairs in Western Australia between April 2012 and December 2017. Maternal vaccine information was obtained from a state-wide antenatal vaccination database. Mortality was defined as a record of a death registration. We used Cox proportional hazard models, weighted by the inverse-probability of treatment (vaccination), to estimate the hazard ratio of child mortality associated with in utero exposure to seasonal IIV. This study found no association between in utero exposure to seasonal IIV and mortality through age five years.
Keywords: Child health; Maternal vaccination; Mortality; Seasonal influenza vaccine; Vaccine safety.