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Vaccine . Improving cross-protection against influenza virus in mice using a nanoparticle vaccine of mini-HA

tetano

tetano

Editor, Senior Moderator
Vaccine


. 2022 Sep 26;S0264-410X(22)01165-3.
doi: 10.1016/j.vaccine.2022.09.058. Online ahead of print.
Improving cross-protection against influenza virus in mice using a nanoparticle vaccine of mini-HA


Hechao Zhu[SUP] 1 [/SUP], Xiangmin Li[SUP] 2 [/SUP], Xujiao Ren[SUP] 1 [/SUP], Huanchun Chen[SUP] 2 [/SUP], Ping Qian[SUP] 3 [/SUP]



Affiliations

Abstract

This study aimed to investigate the protective effect of mini-hemagglutinin (mini-HA) proteins expressed on lumazine synthase (LS) nanoparticles against influenza. Soluble mini-HA proteins were assembled with LS proteins via SpyTag/SpyCatcher in vitro. The size of mini-HA-LS nanoparticles was characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS), and the effect of mini-HA-LS nano-vaccines was explored in mice. The results indicate that the diameter of mini-HA-LS nanoparticles was approximately 60-80 nm. The nanoparticles could induce stronger humoral and cellular immune responses and produce cross-clade protection against influenza in mice.

Keywords: Hemagglutinin (HA); Influenza virus; Lumazine synthase; Vaccine.
 
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