tetano
Editor, Senior Moderator
Vaccine
. 2025 Nov 19:69:127997.
doi: 10.1016/j.vaccine.2025.127997. Online ahead of print. Immunogenicity of JN.1 and KP.2 COVID-19 mRNA vaccines against emerging SARS-CoV-2 variants
Ninaad Lasrado[SUP] 1 [/SUP], Annika Rössler[SUP] 1 [/SUP], Isabella McConnell[SUP] 1 [/SUP], Katherine Molloy[SUP] 1 [/SUP], Ritobhas Bhowmik[SUP] 1 [/SUP], Christine Happle[SUP] 2 [/SUP], Ruoran Guan[SUP] 1 [/SUP], Katherine McMahan[SUP] 1 [/SUP], Juliana Pereira[SUP] 1 [/SUP], Jinyan Liu[SUP] 1 [/SUP], Erica Borducchi[SUP] 1 [/SUP], Liping Wang[SUP] 1 [/SUP], Krishna Shah[SUP] 1 [/SUP], Bridget Wixted[SUP] 1 [/SUP], Metodi V Stankov[SUP] 3 [/SUP], Alexandra Dopfer-Jablonka[SUP] 3 [/SUP], Ai-Ris Y Collier[SUP] 1 [/SUP], Georg M N Behrens[SUP] 4 [/SUP], Dan H Barouch[SUP] 5 [/SUP]
Affiliations
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to evolve five years after the initial outbreak. Although mRNA vaccines encoding the JN.1 and KP.2 Spike proteins were authorized in fall 2024, it remains unclear whether vaccine updates will be necessary for variants containing antigenically closely related Spike proteins. In this study, we evaluated the immunogenicity of JN.1 and KP.2 mRNA boosters in participants from Germany and the United States, respectively. Both vaccines induced robust and similar neutralizing antibody responses against JN.1, KP.2, and other globally relevant variants such as LP.8.1.1 and NB.1.8.1. These data suggest that updating the vaccine formulation to closely related strains will likely offer only modest additional benefits against currently circulating variants.
Keywords: Booster; COVID-19; JN.1; KP.2; mRNA.
. 2025 Nov 19:69:127997.
doi: 10.1016/j.vaccine.2025.127997. Online ahead of print. Immunogenicity of JN.1 and KP.2 COVID-19 mRNA vaccines against emerging SARS-CoV-2 variants
Ninaad Lasrado[SUP] 1 [/SUP], Annika Rössler[SUP] 1 [/SUP], Isabella McConnell[SUP] 1 [/SUP], Katherine Molloy[SUP] 1 [/SUP], Ritobhas Bhowmik[SUP] 1 [/SUP], Christine Happle[SUP] 2 [/SUP], Ruoran Guan[SUP] 1 [/SUP], Katherine McMahan[SUP] 1 [/SUP], Juliana Pereira[SUP] 1 [/SUP], Jinyan Liu[SUP] 1 [/SUP], Erica Borducchi[SUP] 1 [/SUP], Liping Wang[SUP] 1 [/SUP], Krishna Shah[SUP] 1 [/SUP], Bridget Wixted[SUP] 1 [/SUP], Metodi V Stankov[SUP] 3 [/SUP], Alexandra Dopfer-Jablonka[SUP] 3 [/SUP], Ai-Ris Y Collier[SUP] 1 [/SUP], Georg M N Behrens[SUP] 4 [/SUP], Dan H Barouch[SUP] 5 [/SUP]
Affiliations
- PMID: 41265004
- DOI: 10.1016/j.vaccine.2025.127997
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to evolve five years after the initial outbreak. Although mRNA vaccines encoding the JN.1 and KP.2 Spike proteins were authorized in fall 2024, it remains unclear whether vaccine updates will be necessary for variants containing antigenically closely related Spike proteins. In this study, we evaluated the immunogenicity of JN.1 and KP.2 mRNA boosters in participants from Germany and the United States, respectively. Both vaccines induced robust and similar neutralizing antibody responses against JN.1, KP.2, and other globally relevant variants such as LP.8.1.1 and NB.1.8.1. These data suggest that updating the vaccine formulation to closely related strains will likely offer only modest additional benefits against currently circulating variants.
Keywords: Booster; COVID-19; JN.1; KP.2; mRNA.