tetano
Editor, Senior Moderator
Vaccine
. 2022 Oct 13;S0264-410X(22)01215-4.
doi: 10.1016/j.vaccine.2022.09.085. Online ahead of print.
High-dose influenza vaccines for the prevention of hospitalization due to cardiovascular events in older adults in the nursing home: Post-hoc analysis of a cluster-randomized trial
Elie A Saade[SUP] 1 [/SUP], Yasin Abul[SUP] 2 [/SUP], Kevin McConeghy[SUP] 2 [/SUP], H Edward Davidson[SUP] 3 [/SUP], Lisa Han[SUP] 3 [/SUP], Nina Joyce[SUP] 4 [/SUP], David H Canaday[SUP] 5 [/SUP], Leon Hsueh[SUP] 6 [/SUP], Elliott Bosco[SUP] 4 [/SUP], Stefan Gravenstein[SUP] 7 [/SUP]
Affiliations
Abstract
Older adults are at high risk of major acute cardiovascular events (MACE) linked to influenza illness andpreventable by influenza vaccination. It is unknown whether high-dose vaccine might incrementally reduce the risk of MACE.We conducted a post-hoc analysis of data collected from a pragmatic cluster randomized study of 823 nursing homes (NH) randomized to standard-dose (SD) or high-dose (HD) influenza vaccine in the 2013-14 season. Adults age 65 year or older who are Medicare-enrolled long-stay residents were included in the analysis.There were no statistically significant differences in hospitalization for MACE, acute coronary syndromes (ACS), stroke or heart failure between the HD and SD arms. However, in the fee-for-service group, participants in the HD arm had significantly decreased risk of hospitalization for respiratory problems, which was not observed in the Medicare Advantage group.High-dose influenza vaccine was not shown to be incrementally protective against MACE relative to standard-dose vaccine.
Keywords: High-dose influenza vaccine; Influenza; Influenza vaccines/administration & dosage; Nursing homes; Outbreaks.
. 2022 Oct 13;S0264-410X(22)01215-4.
doi: 10.1016/j.vaccine.2022.09.085. Online ahead of print.
High-dose influenza vaccines for the prevention of hospitalization due to cardiovascular events in older adults in the nursing home: Post-hoc analysis of a cluster-randomized trial
Elie A Saade[SUP] 1 [/SUP], Yasin Abul[SUP] 2 [/SUP], Kevin McConeghy[SUP] 2 [/SUP], H Edward Davidson[SUP] 3 [/SUP], Lisa Han[SUP] 3 [/SUP], Nina Joyce[SUP] 4 [/SUP], David H Canaday[SUP] 5 [/SUP], Leon Hsueh[SUP] 6 [/SUP], Elliott Bosco[SUP] 4 [/SUP], Stefan Gravenstein[SUP] 7 [/SUP]
Affiliations
- PMID: 36244879
- DOI: 10.1016/j.vaccine.2022.09.085
Abstract
Older adults are at high risk of major acute cardiovascular events (MACE) linked to influenza illness andpreventable by influenza vaccination. It is unknown whether high-dose vaccine might incrementally reduce the risk of MACE.We conducted a post-hoc analysis of data collected from a pragmatic cluster randomized study of 823 nursing homes (NH) randomized to standard-dose (SD) or high-dose (HD) influenza vaccine in the 2013-14 season. Adults age 65 year or older who are Medicare-enrolled long-stay residents were included in the analysis.There were no statistically significant differences in hospitalization for MACE, acute coronary syndromes (ACS), stroke or heart failure between the HD and SD arms. However, in the fee-for-service group, participants in the HD arm had significantly decreased risk of hospitalization for respiratory problems, which was not observed in the Medicare Advantage group.High-dose influenza vaccine was not shown to be incrementally protective against MACE relative to standard-dose vaccine.
Keywords: High-dose influenza vaccine; Influenza; Influenza vaccines/administration & dosage; Nursing homes; Outbreaks.