tetano
Editor, Senior Moderator
Vaccine
. 2024 Oct 14;42(26):126436.
doi: 10.1016/j.vaccine.2024.126436. Online ahead of print. Field production efficiency investigation of broilers immunized with a turkey herpesvirus vector vaccine expressing hemagglutinin from H9N2 subtype avian influenza virus
Liu Litao[SUP] 1 [/SUP], Chen Feng[SUP] 2 [/SUP], Zhao Hongyu[SUP] 1 [/SUP], Chen Wenbin[SUP] 1 [/SUP], Meng Fanlei[SUP] 2 [/SUP], Zhang Dandan[SUP] 2 [/SUP], Jing Xun[SUP] 1 [/SUP], Li Xinyu[SUP] 1 [/SUP], Liang Qiaomei[SUP] 1 [/SUP], Sun Honglei[SUP] 1 [/SUP], Sun Yipeng[SUP] 1 [/SUP], Pu Juan[SUP] 1 [/SUP], Liu Jinhua[SUP] 3 [/SUP]
Affiliations
Turkey herpesvirus (HVT) vector vaccine expressing hemagglutinin from the H9N2 AIV, namely HVT-H9, were demonstrated to block H9N2 AIV infection and transmission in chickens. In this study, we evaluated the protection efficiency and production performance of broilers in HVT-H9 field trials in the presence or absence of the H9N2 AIV natural infection. HI titers against H9N2 AIV in broilers harboring maternal antibodies were successfully induced by HVT-H9. In the presence of H9N2 AIV natural infection, immunization with HVT-H9 blocked H9N2 AIV infection and reduced the mortality rate. Importantly, HVT-H9 vaccination slightly increased broiler weight and decreased the feed conversion rate in the absence of the H9N2 AIV natural infection but significantly reduced mortality rates and increased production efficiency during the H9N2 AIV natural infection. In summary, HVT-H9 immunization might block H9N2 AIV infection and improve production efficiency in the field, especially in the presence of H9N2 AIV natural infection.
Keywords: Block virus infection and transmission; Field trial; HVT-H9; Maternal antibodies interference; Production efficiency; Turkey herpesvirus vector vaccine.
. 2024 Oct 14;42(26):126436.
doi: 10.1016/j.vaccine.2024.126436. Online ahead of print. Field production efficiency investigation of broilers immunized with a turkey herpesvirus vector vaccine expressing hemagglutinin from H9N2 subtype avian influenza virus
Liu Litao[SUP] 1 [/SUP], Chen Feng[SUP] 2 [/SUP], Zhao Hongyu[SUP] 1 [/SUP], Chen Wenbin[SUP] 1 [/SUP], Meng Fanlei[SUP] 2 [/SUP], Zhang Dandan[SUP] 2 [/SUP], Jing Xun[SUP] 1 [/SUP], Li Xinyu[SUP] 1 [/SUP], Liang Qiaomei[SUP] 1 [/SUP], Sun Honglei[SUP] 1 [/SUP], Sun Yipeng[SUP] 1 [/SUP], Pu Juan[SUP] 1 [/SUP], Liu Jinhua[SUP] 3 [/SUP]
Affiliations
- PMID: 39405642
- DOI: 10.1016/j.vaccine.2024.126436
Turkey herpesvirus (HVT) vector vaccine expressing hemagglutinin from the H9N2 AIV, namely HVT-H9, were demonstrated to block H9N2 AIV infection and transmission in chickens. In this study, we evaluated the protection efficiency and production performance of broilers in HVT-H9 field trials in the presence or absence of the H9N2 AIV natural infection. HI titers against H9N2 AIV in broilers harboring maternal antibodies were successfully induced by HVT-H9. In the presence of H9N2 AIV natural infection, immunization with HVT-H9 blocked H9N2 AIV infection and reduced the mortality rate. Importantly, HVT-H9 vaccination slightly increased broiler weight and decreased the feed conversion rate in the absence of the H9N2 AIV natural infection but significantly reduced mortality rates and increased production efficiency during the H9N2 AIV natural infection. In summary, HVT-H9 immunization might block H9N2 AIV infection and improve production efficiency in the field, especially in the presence of H9N2 AIV natural infection.
Keywords: Block virus infection and transmission; Field trial; HVT-H9; Maternal antibodies interference; Production efficiency; Turkey herpesvirus vector vaccine.