tetano
Editor, Senior Moderator
Vaccine
. 2021 Dec 21;S0264-410X(21)01624-8.
doi: 10.1016/j.vaccine.2021.12.016. Online ahead of print.
Effectiveness of seasonal influenza vaccine in adult Japanese workers, 2017-2020
Kiyoshi Tadakuma[SUP] 1 [/SUP], Takashi Maruyama[SUP] 2 [/SUP], Koji Mori[SUP] 3 [/SUP], Nobuhiro Fujiki[SUP] 4 [/SUP]
Affiliations
Abstract
Background: Previous studies have not estimated vaccine effectiveness (VE) against influenza in the working-age Japanese population. In this study, we determined VE in adult workers at a Japanese company.
Methods: We estimated VE based on self-reported data regarding influenza infections and vaccinations in employees of an auto parts manufacturing company during three influenza seasons from 2017 to 2020. VE was estimated as 100% × [1 - odds ratio (the ratio of the odds of being diagnosed with influenza among enrollees with and without influenza vaccination)]. Odds ratios were estimated using logistic regression.
Results: We included 11,347 worker records [3,592 (2017-18), 3,663 (2018-19), and 4,092 (2019-20)] from employees who had worked with the company throughout each influenza season. The adjusted VE was moderate and significant in the 2019-20 season (VE = 53%; 95% confidence interval [CI] = 30% to 69%) but low or negative and non-significant during the 2017-18 (VE = 28%; 95% CI = -5% to 50%) and 2018-19 (VE = -11%; 95% CI = - 42% to 14%) seasons.
Conclusions: Influenza vaccines were moderately effective during the 2019-20 season but showed low or negative effectiveness during the 2017-18 and 2018-19 seasons. Self-reports from worker records can successfully help determine VE against influenza.
Keywords: Adults; Influenza; Influenza vaccines; Vaccine effectiveness; Workers.
. 2021 Dec 21;S0264-410X(21)01624-8.
doi: 10.1016/j.vaccine.2021.12.016. Online ahead of print.
Effectiveness of seasonal influenza vaccine in adult Japanese workers, 2017-2020
Kiyoshi Tadakuma[SUP] 1 [/SUP], Takashi Maruyama[SUP] 2 [/SUP], Koji Mori[SUP] 3 [/SUP], Nobuhiro Fujiki[SUP] 4 [/SUP]
Affiliations
- PMID: 34952756
- DOI: 10.1016/j.vaccine.2021.12.016
Abstract
Background: Previous studies have not estimated vaccine effectiveness (VE) against influenza in the working-age Japanese population. In this study, we determined VE in adult workers at a Japanese company.
Methods: We estimated VE based on self-reported data regarding influenza infections and vaccinations in employees of an auto parts manufacturing company during three influenza seasons from 2017 to 2020. VE was estimated as 100% × [1 - odds ratio (the ratio of the odds of being diagnosed with influenza among enrollees with and without influenza vaccination)]. Odds ratios were estimated using logistic regression.
Results: We included 11,347 worker records [3,592 (2017-18), 3,663 (2018-19), and 4,092 (2019-20)] from employees who had worked with the company throughout each influenza season. The adjusted VE was moderate and significant in the 2019-20 season (VE = 53%; 95% confidence interval [CI] = 30% to 69%) but low or negative and non-significant during the 2017-18 (VE = 28%; 95% CI = -5% to 50%) and 2018-19 (VE = -11%; 95% CI = - 42% to 14%) seasons.
Conclusions: Influenza vaccines were moderately effective during the 2019-20 season but showed low or negative effectiveness during the 2017-18 and 2018-19 seasons. Self-reports from worker records can successfully help determine VE against influenza.
Keywords: Adults; Influenza; Influenza vaccines; Vaccine effectiveness; Workers.