tetano
Editor, Senior Moderator
Vaccine. 2020 May 8. pii: S0264-410X(20)30564-8. doi: 10.1016/j.vaccine.2020.04.060. [Epub ahead of print]
Effectiveness of quadrivalent influenza vaccine in pregnant women and infants, 2018-2019.
Maltezou HC[SUP]1[/SUP], Asimakopoulos G[SUP]2[/SUP], Stavrou S[SUP]2[/SUP], Daskalakis G[SUP]2[/SUP], Koutroumanis P[SUP]2[/SUP], Sindos M[SUP]2[/SUP], Theodora M[SUP]2[/SUP], Katerelos P[SUP]3[/SUP], Kostis E[SUP]4[/SUP], Gavrili S[SUP]5[/SUP], Kossyvakis A[SUP]6[/SUP], Theodoridou M[SUP]7[/SUP], Mentis A[SUP]6[/SUP], Drakakis P[SUP]2[/SUP], Loutradis D[SUP]2[/SUP], Rodolakis A[SUP]2[/SUP].
Author information
Abstract
Influenza is associated with an increased risk for serious illness, hospitalization and/or death in pregnant women and young infants. We prospectively studied the effectiveness of a quadrivalent inactivated influenza vaccine (QIV) in pregnant women and their infants during the 2018-2019 influenza season. A QIV was offered to pregnant women cared in a maternity hospital in Athens. Women were contacted weekly by telephone during the influenza season and PCR test was offered to women or infants who developed influenza-like illness (ILI). We studied 423 pregnant women and 446 infants. Unvaccinated pregnant women had a 7.5% probability to develop laboratory-confirmed influenza compared to 2.1% among vaccinated women (Odds ratio: 3.6; confidence intervals: 1.14-11.34, p-value = 0.029). Infants whose mothers were not vaccinated had a 7.9% probability to develop laboratory-confirmed influenza compared to 2.8% among infants of vaccinated mothers (Odds ratio = 2.849, confidence intervals: 0.892-9.102, p-value = 0.053). Cox regression analyses showed that QIV vaccination was significantly associated with a decreased probability for laboratory-confirmed influenza, ILI, healthcare seeking and hospitalization among pregnant women and a decreased probability for laboratory-confirmed influenza, healthcare seeking and prescription of antibiotics among infants. The effectiveness of QIV against laboratory-confirmed influenza was 72% among pregnant women and 64.5% among infants during the 2018-2019 influenza season. Vaccination of pregnant women with the QIV was associated with a lower risk for laboratory-confirmed influenza for them and their infants during the influenza season. Our findings strongly support the World Health Organization recommendations for vaccinating pregnant women against influenza.
Copyright ? 2020 Elsevier Ltd. All rights reserved.
KEYWORDS:
Effectiveness; Infants; Influenza vaccination; Pregnant women; Quadrivalent
PMID:32402751DOI:10.1016/j.vaccine.2020.04.060
Effectiveness of quadrivalent influenza vaccine in pregnant women and infants, 2018-2019.
Maltezou HC[SUP]1[/SUP], Asimakopoulos G[SUP]2[/SUP], Stavrou S[SUP]2[/SUP], Daskalakis G[SUP]2[/SUP], Koutroumanis P[SUP]2[/SUP], Sindos M[SUP]2[/SUP], Theodora M[SUP]2[/SUP], Katerelos P[SUP]3[/SUP], Kostis E[SUP]4[/SUP], Gavrili S[SUP]5[/SUP], Kossyvakis A[SUP]6[/SUP], Theodoridou M[SUP]7[/SUP], Mentis A[SUP]6[/SUP], Drakakis P[SUP]2[/SUP], Loutradis D[SUP]2[/SUP], Rodolakis A[SUP]2[/SUP].
Author information
Abstract
Influenza is associated with an increased risk for serious illness, hospitalization and/or death in pregnant women and young infants. We prospectively studied the effectiveness of a quadrivalent inactivated influenza vaccine (QIV) in pregnant women and their infants during the 2018-2019 influenza season. A QIV was offered to pregnant women cared in a maternity hospital in Athens. Women were contacted weekly by telephone during the influenza season and PCR test was offered to women or infants who developed influenza-like illness (ILI). We studied 423 pregnant women and 446 infants. Unvaccinated pregnant women had a 7.5% probability to develop laboratory-confirmed influenza compared to 2.1% among vaccinated women (Odds ratio: 3.6; confidence intervals: 1.14-11.34, p-value = 0.029). Infants whose mothers were not vaccinated had a 7.9% probability to develop laboratory-confirmed influenza compared to 2.8% among infants of vaccinated mothers (Odds ratio = 2.849, confidence intervals: 0.892-9.102, p-value = 0.053). Cox regression analyses showed that QIV vaccination was significantly associated with a decreased probability for laboratory-confirmed influenza, ILI, healthcare seeking and hospitalization among pregnant women and a decreased probability for laboratory-confirmed influenza, healthcare seeking and prescription of antibiotics among infants. The effectiveness of QIV against laboratory-confirmed influenza was 72% among pregnant women and 64.5% among infants during the 2018-2019 influenza season. Vaccination of pregnant women with the QIV was associated with a lower risk for laboratory-confirmed influenza for them and their infants during the influenza season. Our findings strongly support the World Health Organization recommendations for vaccinating pregnant women against influenza.
Copyright ? 2020 Elsevier Ltd. All rights reserved.
KEYWORDS:
Effectiveness; Infants; Influenza vaccination; Pregnant women; Quadrivalent
PMID:32402751DOI:10.1016/j.vaccine.2020.04.060