tetano
Editor, Senior Moderator
Vaccine
. 2024 Jul 16:S0264-410X(24)00806-5.
doi: 10.1016/j.vaccine.2024.07.043. Online ahead of print. Effectiveness of influenza vaccination on hospitalization outcomes among older patients with diabetes
Guangqi Liu[SUP] 1 [/SUP], Yuanjie Pang[SUP] 2 [/SUP], Min Lv[SUP] 3 [/SUP], Ming Lu[SUP] 4 [/SUP], Yangmu Huang[SUP] 5 [/SUP], Fei Ge[SUP] 6 [/SUP], Shiwei Ma[SUP] 7 [/SUP], Yongxiang Qiu[SUP] 6 [/SUP]
Affiliations
Objective: In older populations admitted for diabetes, limited evidence suggests that influenza vaccination protects against hospitalization outcomes.
Methods: This study pooled 27,620 hospitalizations recorded for elderly diabetes patients from the Beijing Elderly Influenza Vaccination Information Registration Database (2013-2018) and the Beijing Urban Employee Basic Medical Insurance Database (2013-2018). Generalized linear regression and propensity score matching were conducted to estimate the effects of influenza vaccination on hospitalization outcomes (in-hospital all-cause mortality, readmission, length and costs of hospitalization), adjusting for measurable confounding factors. The low influenza period (May-July) was used as a reference period to adjust for unmeasured confounding factors during the peak influenza period (November-January).
Results: In propensity score matching, influenza vaccination in peak influenza period could reduce the risk of in-hospital death (OR: 0.47[0.22,0.97]) and readmission (OR: 0.70[0.60,0.81]), length of hospitalization (β: -1.32[-1.47, -1.17]) and medical costs (GMR: 0.90[0.88,0.92]). After adjusting for unmeasured confounding factors, influenza vaccination was associated with 17% (ratio of ORs: 0.83 [0.69, 1.02]) lower risk of readmission and shorter length of hospitalization (difference in β: -0.23 [-0.62, 0.16]). The subgroup analyses showed that male patients with older age and poorer health conditions could benefit more after influenza vaccination.
Conclusion: Influenza vaccination could significantly improve hospitalization outcomes in elderly diabetic patients. This provides evidence supporting free influenza vaccination policies for vulnerable populations in low- and middle-income countries.
Keywords: Aged population; Diabetes; Influenza; Vaccine effectiveness.
. 2024 Jul 16:S0264-410X(24)00806-5.
doi: 10.1016/j.vaccine.2024.07.043. Online ahead of print. Effectiveness of influenza vaccination on hospitalization outcomes among older patients with diabetes
Guangqi Liu[SUP] 1 [/SUP], Yuanjie Pang[SUP] 2 [/SUP], Min Lv[SUP] 3 [/SUP], Ming Lu[SUP] 4 [/SUP], Yangmu Huang[SUP] 5 [/SUP], Fei Ge[SUP] 6 [/SUP], Shiwei Ma[SUP] 7 [/SUP], Yongxiang Qiu[SUP] 6 [/SUP]
Affiliations
- PMID: 39019658
- DOI: 10.1016/j.vaccine.2024.07.043
Objective: In older populations admitted for diabetes, limited evidence suggests that influenza vaccination protects against hospitalization outcomes.
Methods: This study pooled 27,620 hospitalizations recorded for elderly diabetes patients from the Beijing Elderly Influenza Vaccination Information Registration Database (2013-2018) and the Beijing Urban Employee Basic Medical Insurance Database (2013-2018). Generalized linear regression and propensity score matching were conducted to estimate the effects of influenza vaccination on hospitalization outcomes (in-hospital all-cause mortality, readmission, length and costs of hospitalization), adjusting for measurable confounding factors. The low influenza period (May-July) was used as a reference period to adjust for unmeasured confounding factors during the peak influenza period (November-January).
Results: In propensity score matching, influenza vaccination in peak influenza period could reduce the risk of in-hospital death (OR: 0.47[0.22,0.97]) and readmission (OR: 0.70[0.60,0.81]), length of hospitalization (β: -1.32[-1.47, -1.17]) and medical costs (GMR: 0.90[0.88,0.92]). After adjusting for unmeasured confounding factors, influenza vaccination was associated with 17% (ratio of ORs: 0.83 [0.69, 1.02]) lower risk of readmission and shorter length of hospitalization (difference in β: -0.23 [-0.62, 0.16]). The subgroup analyses showed that male patients with older age and poorer health conditions could benefit more after influenza vaccination.
Conclusion: Influenza vaccination could significantly improve hospitalization outcomes in elderly diabetic patients. This provides evidence supporting free influenza vaccination policies for vulnerable populations in low- and middle-income countries.
Keywords: Aged population; Diabetes; Influenza; Vaccine effectiveness.