tetano
Editor, Senior Moderator
Vaccine
Available online 18 October 2012
In Press, Uncorrected Proof ? Note to users
Cover image
Effectiveness of an influenza A (H1N1) 2009 monovalent vaccine among Japanese pregnant women: A prospective observational study assessing antibody efficacy
Wakaba Fukushimaa, Corresponding author contact information, E-mail the corresponding author,
Satoko Ohfujia,
Masaaki Deguchib, 1,
Kazume Kawabatac,
Hideaki Hatayamaa,
Hideki Yoshidad,
Akiko Maedaa,
Yoshio Hirotaa
a Department of Public Health, Osaka City University Faculty of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
b Department of Obstetrics and Gynecology, Osaka City Juso Hospital, 2-12-27, Nonaka-kita, Yodogawa-ku, Osaka 532-0034, Japan
c Kawabata Women's Clinic, 1-22-10, Miyakojima-kitadori, Miyakojima-ku, Osaka 534-0014, Japan
d Division of Infectious Disease Control, Osaka City Public Health Office, 1-2-7-1000, Asahi-machi, Abeno-ku, Osaka 545-0051, Japan
http://dx.doi.org/10.1016/j.vaccine.2012.10.027, How to Cite or Link Using DOI
Abstract
In order to estimate the effectiveness of an influenza A (H1N1) 2009 monovalent vaccine among pregnant women, we prospectively observed 135 Japanese pregnant women who received an influenza A (H1N1) 2009 monovalent vaccine during November 2009. We calculated an index of ?antibody efficacy?, in which the medical visits for respiratory illnesses were compared between those with and without post-vaccination hemagglutination inhibition (HI) titer ≥1:40. The product of antibody efficacy and achievement rate is theoretically equivalent to the vaccine effectiveness. Among all subjects, an inverse but non-significant relationship during the epidemic period was observed between post-vaccination HI titer ≥1:40 and medical visits for respiratory illnesses. After stratification by trimester at recruitment, a significant inverse association during the epidemic period was found among subjects in the first or second trimester (antibody efficacy: 91%, vaccine effectiveness: 79%). The influenza A (H1N1) 2009 monovalent vaccine administered in the first or second trimester reduced medical visits for respiratory illnesses among Japanese pregnant women.
Highlights
► Effectiveness of an influenza A (H1N1) 2009 monovalent vaccine was estimated. ► We prospectively observed 135 Japanese pregnant women. ► Vaccine effectiveness was calculated using an index of ?antibody efficacy?. ► Antibody efficacy was 91% among subjects in the first or second trimester at recruitment. ► The corresponding vaccine effectiveness was estimated to be 79%.
http://www.sciencedirect.com/science/article/pii/S0264410X12014739
Available online 18 October 2012
In Press, Uncorrected Proof ? Note to users
Cover image
Effectiveness of an influenza A (H1N1) 2009 monovalent vaccine among Japanese pregnant women: A prospective observational study assessing antibody efficacy
Wakaba Fukushimaa, Corresponding author contact information, E-mail the corresponding author,
Satoko Ohfujia,
Masaaki Deguchib, 1,
Kazume Kawabatac,
Hideaki Hatayamaa,
Hideki Yoshidad,
Akiko Maedaa,
Yoshio Hirotaa
a Department of Public Health, Osaka City University Faculty of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
b Department of Obstetrics and Gynecology, Osaka City Juso Hospital, 2-12-27, Nonaka-kita, Yodogawa-ku, Osaka 532-0034, Japan
c Kawabata Women's Clinic, 1-22-10, Miyakojima-kitadori, Miyakojima-ku, Osaka 534-0014, Japan
d Division of Infectious Disease Control, Osaka City Public Health Office, 1-2-7-1000, Asahi-machi, Abeno-ku, Osaka 545-0051, Japan
http://dx.doi.org/10.1016/j.vaccine.2012.10.027, How to Cite or Link Using DOI
Abstract
In order to estimate the effectiveness of an influenza A (H1N1) 2009 monovalent vaccine among pregnant women, we prospectively observed 135 Japanese pregnant women who received an influenza A (H1N1) 2009 monovalent vaccine during November 2009. We calculated an index of ?antibody efficacy?, in which the medical visits for respiratory illnesses were compared between those with and without post-vaccination hemagglutination inhibition (HI) titer ≥1:40. The product of antibody efficacy and achievement rate is theoretically equivalent to the vaccine effectiveness. Among all subjects, an inverse but non-significant relationship during the epidemic period was observed between post-vaccination HI titer ≥1:40 and medical visits for respiratory illnesses. After stratification by trimester at recruitment, a significant inverse association during the epidemic period was found among subjects in the first or second trimester (antibody efficacy: 91%, vaccine effectiveness: 79%). The influenza A (H1N1) 2009 monovalent vaccine administered in the first or second trimester reduced medical visits for respiratory illnesses among Japanese pregnant women.
Highlights
► Effectiveness of an influenza A (H1N1) 2009 monovalent vaccine was estimated. ► We prospectively observed 135 Japanese pregnant women. ► Vaccine effectiveness was calculated using an index of ?antibody efficacy?. ► Antibody efficacy was 91% among subjects in the first or second trimester at recruitment. ► The corresponding vaccine effectiveness was estimated to be 79%.
http://www.sciencedirect.com/science/article/pii/S0264410X12014739