tetano
Editor, Senior Moderator
Vaccine
. 2022 Apr 18;S0264-410X(22)00473-X.
doi: 10.1016/j.vaccine.2022.04.045. Online ahead of print.
Delay between COVID-19 complete vaccination and SARS-CoV-2 infection among healthcare workers
Anastasia Saade[SUP] 1 [/SUP], Leo Cha[SUP] 2 [/SUP], Emilie Tadié[SUP] 2 [/SUP], Bruno Jurado[SUP] 2 [/SUP], Alix Le Bihan[SUP] 2 [/SUP], Pauline Baron-Latouche[SUP] 2 [/SUP], Christine Febreau[SUP] 3 [/SUP], Vincent Thibault[SUP] 3 [/SUP], Ronan Garlantezec[SUP] 4 [/SUP], Pierre Tattevin[SUP] 5 [/SUP], Christophe Paris[SUP] 6 [/SUP]
Affiliations
Abstract
Objectives: Healthcare workers (HCWs), at increased risk of coronavirus disease 2019 (COVID-19) were among the primary targets for vaccination, which became mandatory for them on September 15th, 2021 in France. In November they were confronted to the fifth COVID-19 wave despite excellent vaccine coverage. We aimed to estimate the incidence of SARS-CoV-2 infection after complete vaccination among HCWs with different vaccination schemes, and its determinants.
Methods: We enrolled all HCWs in the university hospital of Rennes, France who had received complete vaccination (two doses of COVID-19 vaccine). The delay from last vaccination dose to SARS-CoV-2 infection was computed.Fitted mixed Cox survival model with a random effect applied to exposure risk periods to account for epidemic variation was used to estimate the determinants of SARS-CoV-2 infection after complete vaccination.
Results: Of the 6674 (82%) HCWs who received complete vaccination (36% BNT162b2, 29% mRNA-1273, and 34% mixed with ChAdOx1 nCoV-19) and were prospectively followed-up for a median of 7.0 [6.3-8.0] months, 160 (2.4%) tested positive for SARS-CoV-2 by RT-PCR. Incidence density of SARS-CoV-2 infection after complete vaccination was 3.39 [2.89-3.96] infections per 1000 person-month. Median time from vaccine completion to SARS-CoV-2 infection was 5.5 [3.2-6.6] months. Using fitted mixed Cox regression with the delay as a time-dependent variable and random effect applied to exposure risk periods, age (P < 0.001) was independently associated with the incidence of SARS-CoV-2 infection. Vaccine schemes were not associated with SARS-CoV-2 infection (P = 0.068). A period effect was significantly associated with the incidence of SARS-CoV-2 infection (P < 0.001).
Conclusions: In this real-world study, incidence of SARS-CoV-2 infection increases with time in fully vaccinated HCWs with no differences according to the vaccination scheme. The short delay between complete vaccination and incident SARS-CoV-2 infection highlights the need for sustained barrier measures even in fully vaccinated HCWs.
Keywords: COVID-19; Complete vaccination; Healthcare workers; SARS-CoV-2 infection; Vaccine.
. 2022 Apr 18;S0264-410X(22)00473-X.
doi: 10.1016/j.vaccine.2022.04.045. Online ahead of print.
Delay between COVID-19 complete vaccination and SARS-CoV-2 infection among healthcare workers
Anastasia Saade[SUP] 1 [/SUP], Leo Cha[SUP] 2 [/SUP], Emilie Tadié[SUP] 2 [/SUP], Bruno Jurado[SUP] 2 [/SUP], Alix Le Bihan[SUP] 2 [/SUP], Pauline Baron-Latouche[SUP] 2 [/SUP], Christine Febreau[SUP] 3 [/SUP], Vincent Thibault[SUP] 3 [/SUP], Ronan Garlantezec[SUP] 4 [/SUP], Pierre Tattevin[SUP] 5 [/SUP], Christophe Paris[SUP] 6 [/SUP]
Affiliations
- PMID: 35465980
- DOI: 10.1016/j.vaccine.2022.04.045
Abstract
Objectives: Healthcare workers (HCWs), at increased risk of coronavirus disease 2019 (COVID-19) were among the primary targets for vaccination, which became mandatory for them on September 15th, 2021 in France. In November they were confronted to the fifth COVID-19 wave despite excellent vaccine coverage. We aimed to estimate the incidence of SARS-CoV-2 infection after complete vaccination among HCWs with different vaccination schemes, and its determinants.
Methods: We enrolled all HCWs in the university hospital of Rennes, France who had received complete vaccination (two doses of COVID-19 vaccine). The delay from last vaccination dose to SARS-CoV-2 infection was computed.Fitted mixed Cox survival model with a random effect applied to exposure risk periods to account for epidemic variation was used to estimate the determinants of SARS-CoV-2 infection after complete vaccination.
Results: Of the 6674 (82%) HCWs who received complete vaccination (36% BNT162b2, 29% mRNA-1273, and 34% mixed with ChAdOx1 nCoV-19) and were prospectively followed-up for a median of 7.0 [6.3-8.0] months, 160 (2.4%) tested positive for SARS-CoV-2 by RT-PCR. Incidence density of SARS-CoV-2 infection after complete vaccination was 3.39 [2.89-3.96] infections per 1000 person-month. Median time from vaccine completion to SARS-CoV-2 infection was 5.5 [3.2-6.6] months. Using fitted mixed Cox regression with the delay as a time-dependent variable and random effect applied to exposure risk periods, age (P < 0.001) was independently associated with the incidence of SARS-CoV-2 infection. Vaccine schemes were not associated with SARS-CoV-2 infection (P = 0.068). A period effect was significantly associated with the incidence of SARS-CoV-2 infection (P < 0.001).
Conclusions: In this real-world study, incidence of SARS-CoV-2 infection increases with time in fully vaccinated HCWs with no differences according to the vaccination scheme. The short delay between complete vaccination and incident SARS-CoV-2 infection highlights the need for sustained barrier measures even in fully vaccinated HCWs.
Keywords: COVID-19; Complete vaccination; Healthcare workers; SARS-CoV-2 infection; Vaccine.
