tetano
Editor, Senior Moderator
Vaccine
. 2023 Jun 9;S0264-410X(23)00663-1.
doi: 10.1016/j.vaccine.2023.06.011. Online ahead of print. Cellular and humoral immune responses after a third dose of SARS-CoV-2 mRNA vaccine in lung transplant recipients in Japan
Masahiro Ui[SUP] 1 [/SUP], Takashi Hirama[SUP] 2 [/SUP], Miki Akiba[SUP] 3 [/SUP], Masako Honda[SUP] 4 [/SUP], Toshiaki Kikuchi[SUP] 5 [/SUP], Yoshinori Okada[SUP] 6 [/SUP]
Affiliations
Background: Lung transplant (LTx) recipients are at higher risk of infection with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). There is an increasing demand for additional analysis regarding the efficacy and safety of after the initial series of mRNA SARS-CoV-2 vaccines in Japanese transplant recipients.
Method: In this open-label, nonrandomized prospective study carried out at Tohoku University Hospital, Sendai, Japan, LTx recipients and controls received third doses of either the BNT162b2 or the mRNA-1273 vaccine, and the cellular and humoral immune responses were analyzed.
Results: A cohort of 39 LTx recipients and 38 controls participated in the study. The third dose of SARS-CoV-2 vaccine promoted much greater humoral responses at 53.9 % of LTx recipients than after the initial series at 28.2 % of patients without increasing the risk of adverse events. However, still fewer LTx recipients responded to the SARS-CoV-2 spike protein with the median IgG titer of 129.8 AU/mL and with the median IFN-γ level of 0.01 IU/mL when compared to controls with those of 7394 AU/mL and 0.70 IU/mL, respectively.
Conclusion: Although the third dose of mRNA vaccine in LTx recipients was effective and safe, impaired cellular and humoral responses to SARS-CoV-2 spike protein were noted. Given lower antibody production and establishing vaccine safety, repeating the administration of mRNA vaccine will lead to robust protection in such a high-risk population (jRCT1021210009).
Keywords: COVID-19; Japan; Lung transplantation; SARS-CoV-2; Vaccine; mRNA.
. 2023 Jun 9;S0264-410X(23)00663-1.
doi: 10.1016/j.vaccine.2023.06.011. Online ahead of print. Cellular and humoral immune responses after a third dose of SARS-CoV-2 mRNA vaccine in lung transplant recipients in Japan
Masahiro Ui[SUP] 1 [/SUP], Takashi Hirama[SUP] 2 [/SUP], Miki Akiba[SUP] 3 [/SUP], Masako Honda[SUP] 4 [/SUP], Toshiaki Kikuchi[SUP] 5 [/SUP], Yoshinori Okada[SUP] 6 [/SUP]
Affiliations
- PMID: 37328349
- PMCID: PMC10250153
- DOI: 10.1016/j.vaccine.2023.06.011
Background: Lung transplant (LTx) recipients are at higher risk of infection with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). There is an increasing demand for additional analysis regarding the efficacy and safety of after the initial series of mRNA SARS-CoV-2 vaccines in Japanese transplant recipients.
Method: In this open-label, nonrandomized prospective study carried out at Tohoku University Hospital, Sendai, Japan, LTx recipients and controls received third doses of either the BNT162b2 or the mRNA-1273 vaccine, and the cellular and humoral immune responses were analyzed.
Results: A cohort of 39 LTx recipients and 38 controls participated in the study. The third dose of SARS-CoV-2 vaccine promoted much greater humoral responses at 53.9 % of LTx recipients than after the initial series at 28.2 % of patients without increasing the risk of adverse events. However, still fewer LTx recipients responded to the SARS-CoV-2 spike protein with the median IgG titer of 129.8 AU/mL and with the median IFN-γ level of 0.01 IU/mL when compared to controls with those of 7394 AU/mL and 0.70 IU/mL, respectively.
Conclusion: Although the third dose of mRNA vaccine in LTx recipients was effective and safe, impaired cellular and humoral responses to SARS-CoV-2 spike protein were noted. Given lower antibody production and establishing vaccine safety, repeating the administration of mRNA vaccine will lead to robust protection in such a high-risk population (jRCT1021210009).
Keywords: COVID-19; Japan; Lung transplantation; SARS-CoV-2; Vaccine; mRNA.