tetano
Editor, Senior Moderator
Viral Immunol. 2016 Mar 7. [Epub ahead of print]
[h=1]Vaccination with 2014-15 Seasonal Inactivated Influenza Vaccine Elicits Cross-Reactive Anti-HA Antibodies with Strong ADCC Against Antigenically Drifted Circulating H3N2 Virus in Humans.[/h] Zhong W[SUP]1[/SUP], Gross FL[SUP]1[/SUP], Holiday C[SUP]1[/SUP], Jefferson SN[SUP]1[/SUP], Bai Y[SUP]1[/SUP], Liu F[SUP]1[/SUP], Katz JM[SUP]1[/SUP], Levine MZ[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] It is well established that virus neutralizing (VN) antibodies to hemagglutinin (HA) antigens of influenza A viruses provide optimal protection against antigenically matched strains of influenza A viruses. In contrast, little is known about the potential role of HA-specific, non-neutralizing antibodies in protection against human influenza illness at present. In this study, we show that individuals vaccinated with the 2014-15 seasonal inactivated influenza vaccine displayed strong A/H3N2 HA-specific antibody-dependent cell-mediated cytotoxicity (ADCC) activities against an antigenically drifted H3N2 virus, despite poor induction of cross-reactive neutralizing antibodies against the antigenic variant. Given that passive transfer of influenza HA-monospecific immune sera with negligible levels of HA-specific VN antibodies can often confer considerable cross protection against lethal challenge with heterologous influenza viruses in animal models, it is conceivable that HA-specific, non-neutralizing antibodies may provide certain degree of cross protection against antigenically drifted influenza A viruses through ADCC in case of influenza vaccine mismatches. This may have important implications for public health.
PMID: 26950058 [PubMed - as supplied by publisher]
[h=1]Vaccination with 2014-15 Seasonal Inactivated Influenza Vaccine Elicits Cross-Reactive Anti-HA Antibodies with Strong ADCC Against Antigenically Drifted Circulating H3N2 Virus in Humans.[/h] Zhong W[SUP]1[/SUP], Gross FL[SUP]1[/SUP], Holiday C[SUP]1[/SUP], Jefferson SN[SUP]1[/SUP], Bai Y[SUP]1[/SUP], Liu F[SUP]1[/SUP], Katz JM[SUP]1[/SUP], Levine MZ[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] It is well established that virus neutralizing (VN) antibodies to hemagglutinin (HA) antigens of influenza A viruses provide optimal protection against antigenically matched strains of influenza A viruses. In contrast, little is known about the potential role of HA-specific, non-neutralizing antibodies in protection against human influenza illness at present. In this study, we show that individuals vaccinated with the 2014-15 seasonal inactivated influenza vaccine displayed strong A/H3N2 HA-specific antibody-dependent cell-mediated cytotoxicity (ADCC) activities against an antigenically drifted H3N2 virus, despite poor induction of cross-reactive neutralizing antibodies against the antigenic variant. Given that passive transfer of influenza HA-monospecific immune sera with negligible levels of HA-specific VN antibodies can often confer considerable cross protection against lethal challenge with heterologous influenza viruses in animal models, it is conceivable that HA-specific, non-neutralizing antibodies may provide certain degree of cross protection against antigenically drifted influenza A viruses through ADCC in case of influenza vaccine mismatches. This may have important implications for public health.
PMID: 26950058 [PubMed - as supplied by publisher]